Research Highlights

 

Please join us in congratulating Dr Alexander Vinogradov and his team on their latest study, published in the scientific journal Chem (JCR, IF 19.6), titled “Measuring kcat/KM Values for Over 200,000 Enzymatic Substrates with mRNA Display”. The online article can be accessed here: https://doi.org/10.1016/j.chempr.2025.102737

The study, published in the scientific journal Chem, demonstrates the utility of this approach by conducting a single-shot profiling of a bacterial reductase enzyme, which can be employed to engineer potential therapeutic agents. The authors reliably monitored enzymatic kinetics for 285,000 distinct peptide substrates and validated the results with traditional methods.

 

Read more : Enzymatic kinetics in a ultra-high-throughput format – NUS Faculty of Science