Drug discovery
- Elucidation of mechanism/s of action of natural products, synthetic and semi-synthetic compounds
- Characterization and development of agents that possess potential anticancer, chemopreventive, neuroprotective and anti-inflammatory properties
Complementary and Alternative Medicine and Healthcare education
- Provision of evidence-based information of CAMs to healthcare professionals and trainees via digital means
- Chairperson (Jan 2023 to present), Continuing Professional Education (CPE) Accreditation Committee, Singapore Pharmacy Council
- Council member (Apr 2013 to Mar 2015), Pharmaceutical Society of Singapore (PSS)
- Goh A, Budijono B, Lim C, Chew EH, Yap K. An In-House Developed Probiotics Database E-Reference Information for Healthcare Professionals. Stud Health Technol Inform (2024) 310:239-243.
- Goh ADY, Ng CSM, Toh YG, Chong JBK, Chew EH, Yap KY. Development of a Probiotics Practice E-Reference Database for Health Care Professionals. Clin Ther (2021) 43(12):e364-e376.
- Tan SH, Karuppasamy M, Lan P, Zhang Y, Hu J, Lai X, Siok-Cheng Lim B, Liu W, Chen J, Chew EH, Banwell MG. Ribisins and Certain Analogues Exert Neuroprotective Effects through Activation of the Keap1-Nrf2-ARE Pathway. ChemMedChem (2022) 17(18):e202200292.
- Gan FF, Zhang R, Ng HL, Karuppasamy M, Seah W, Yeap WH, Ong SM, Hadadi E, Wong SC, Chui WK, Chew EH. Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway. Food Chem Toxicol (2018) 116:238-248.
- Ng HL, Chen S, Chew EH, Chui WK. Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity. Eur J Med Chem (2016) 115:63-74.
- Kaminska KK, Bertrand HC, Tajjima H, Stafford WC, Cheng Q, Chen W, Wells G, Arner ES, Chew EH*. Indolin-2-one compounds targeting thioredoxin reductase as potential anticancer drug leads. Oncotarget (2016) 7:40233-40251.
- Shelar SB, Kaminska KK, Reddy SA, Kumar D, Tan CT, Yu VC, Lu J, Holmgren A, Hagen T, Chew EH. Thioredoxin-dependent regulation of AIF-mediated DNA damage. Free Radic Biol Med (2015) 87:125-136.