Pharmaceutical Biology and Pharmacokinetics

Our team of scientists conduct cutting edge research on pharmacology and toxicology to discover novel therapeutics and elucidate mechanisms of toxicity for risk assessment and mitigation. Our key research areas are summarized below.

• Physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD) modeling of pharmacology and toxicology.
• Xenobiotic-derived reactive metabolite research with specific focus on interaction with biological proteins.
• Metabolism-driven systems biology modeling of pathology, pharmacology, toxicology and mammalian host-bacteria interactions.
• Development of next-generation cancer immunotherapies through functional genomics, organoid models, and immune profiling to identify novel tumor antigens and targets for personalized cancer vaccines, TCR-based therapies, and treatments for refractory colorectal, liver, and ovarian cancers.
• Investigation of molecular drivers of chronic liver disease progression—including MAFLD, liver fibrosis, and liver cancer—while exploring nanomaterial-based therapies, drug delivery, liver regeneration, anti-fibrosis strategies, and the impact of environmental contaminants such as nano- and microplastics on liver health.