Full publication list in 2019 and last 22 years
2020
Elsergany, Ramy Nagdy, Chan Lai Wah, Heng Paul Wan Sia
Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting
International Journal of Pharmaceutics 2020: 586, art. no. 119573
Lee Wee Beng, Widjaja Effendi, Heng Paul Wan Sia, Chan Lai Wah
3D projection and multivariate image analysis for quantitative visual modelling of mixability and rheological behavior of lactose powder
European Journal of Pharmaceutics and Biopharmaceutics 2020: 153, 241-256
Elsergany, Ramy Nagdy, Chan Lai Wah, Heng Paul Wan Sia
Influence of the porosity of cushioning excipients on the compaction of coated multi-particulates
European Journal of Pharmaceutics and Biopharmaceutics 2020: 152, 218-228
Siow Carin Ru Shan, Heng Paul Wan Sia, Chan Lai Wah
A study on the impact of HPMC viscosity grade and proportion on the functional properties of co-freeze-dried mannitol-HPMC cushioning excipients for compacted MUPS
European Journal of Pharmaceutics and Biopharmaceutics 2020: 151, 98-107
Hermans, A., Dorozynski, P., Muzzio, F.J., Li, H., Nielsen, S., Chen, S., Reppas, C., Klein, S., Patel, S., Wacker, M., Thakker, K., Pruessmann, K., Seidlitz, A., Ghosh, T.K., Yang, Y., Willett, D., Hochhaus, G., Tay Justin Yong Soon, Liew Celine Valeria, Heng Paul Wan Sia, Sun, C.C., Kraemer, J., Marques, M.R.C.
Workshop report: USP workshop on advancements in in vitro performance testing of drug products
Dissolution Technologies 2020: 27 (2), 52-70
Veronica Natalia, Liew Celine Valeria, Heng Paul Wan Sia
Insights on the role of excipients and tablet matrix porosity on aspirin stability
International Journal of Pharmaceutics 2020: 580, art. no. 119218
Lee Wee Beng, Widjaja Effendi, Heng Paul Wan Sia, Chan Lai Wah
The effect of rotation speed and particle size distribution variability on mixability: An avalanche rheological and multivariate image analytical approach
International Journal of Pharmaceutics 2020: 579, art. no. 119128
Mayandi, V., Xi, Q., Leng Goh, E.T., Koh, S.K., Jie Toh, T.Y., Barathi, V.A., Urf Turabe Fazil, M.H., Somaraju Chalasani, M.L., Varadarajan, J., Jeng Ting, D.S., Beuerman, R.W., Chan Lau Wah, Agrawal, R., Sebastian Barkham, T.M., Zhou, L., Verma, N.K., Lakshminarayanan, R.
Rational Substitution of ϵ-Lysine for α-Lysine Enhances the Cell and Membrane Selectivity of Pore-Forming Melittin
Journal of Medicinal Chemistry 2020: 63 (7), 3522-3537
Teh Liam Chee, Chan Lai Wah, Liew Celine Valeria, Heng Paul Wan Sia
Impact of die wall material on the mechanical properties of paracetamol tablets
International Journal of Pharmaceutics 2020: 574, art. no. 118902
Hiew Tze Ning, Tian Yu Harn, Tan Hueiming, Heng Paul Wan Sia
A mechanistic understanding of compression damage to the dissolubility of coated pellets in tablets
European Journal of Pharmaceutics and Biopharmaceutics 2020: 146, 93-100
2019
Wannaphatchaiyong Suchipa, Heng Paul Wan Sia, Suksaeree Jirapornchai, Prapaporn Boonme, Pichayakorn Wiwat
Lidocaine loaded gelatin/gelatinized tapioca starch films for buccal delivery and the irritancy evaluation using chick chorioallantoic membrane
Saudi Pharmaceutical Journal 2019: 27 (8), 1085-1095
Chunhachaichana Charisopon, Rutthapol Sritharadol, Sawatdee Somchai, Heng Paul Wan Sia, Teerapol Srichana
Development of nanodispersion-based sildenafil metered-dose inhalers stabilized by poloxamer 188: a potential candidate for the treatment of pulmonary arterial hypertension
Pharmaceutical Development and Technology 2019: 24 (10), 1218-1228.
Ouyang Hongyi, Ang Chen Yee, Heng Paul Wan Sia, Chan Lai Wah
Effects of Drug Particle Size and Lipid Additives on Drug Release from Paraffin Wax Formulations Prepared by Spray Congealing Technique
AAPS PharmSciTech 2019: 20 (7), art. no. 303
Kou Xiang, Heng, Heng Paul Wan Sia, Chan Lai Wah,Wereley Steven T, Carvajal M Teresa
Effect of Roughness on the Dispersion of Dry Powders for Inhalation: a Dynamic Visualization Perspective
AAPS PharmSciTech 2019: 20 (7), art. no. 271
Tay Justin Yong Soon, Kok, Berlinda Wen Ting, Liew Celine Valeria, Heng Paul Wan Sia
Effects of particle surface roughness on in-die flow and tableting behavior of lactose
Journal of Pharmaceutical Sciences 2019: 108 (9), 3011-3019
Lee Wee Beng, Widjaja Effendi, Heng Paul Wan Sia, Chan Lai Wah
Near infrared spectroscopy for rapid and in-line detection of particle size distribution variability in lactose during mixing
International Journal of Pharmaceutics 2019: 566: 454-462
Lee Wee Beng, Widjaja Effendi, Heng Paul Wan Sia, Chan Lai Wah
Investigating the effect and mechanism of particle size distribution variability on mixing using avalanche testing and multivariate modelling
International Journal of Pharmaceutics 2019: 563: 9-20
Elsergany, Ramy Nagdy, Chan Lai Wah, Heng Paul Wan Sia
Application of the modified tangential spray-fluidized bed to produce nonpareils from primary crystals
AAPS PharmSciTech 2019: 20 (3): art. no. 138
Goh Hui Ping, Heng Paul Wan Sia, Liew Celine Valeria
The effects of feed frame parameters and turret speed on mini-tablet compression
Journal of Pharmaceutical Sciences 2019: 108 (3):1161-1171
Hiew Tze Ning, Tan Desiree Li Hui, Tiang Yi Long, Heng Paul Wan Sia
Understanding the release performance of pellets with hydrophobic inclusions in sustained-release coating
International Journal of Pharmaceutics 2019: 557: 229-237
Siow Carin Ru Shan, Tang Denyse Shuwen, Heng Paul Wan Sia, Chan Lai Wah
Probing the impact of HPMC viscosity grade and proportion on the physical properties of co-freeze-dried mannitol-HPMC tableting excipients using multivariate analysis methods
International Journal of Pharmaceutics 2019: 556: 246-262
2018
Hiew Tze Ning, Muhammad Ismail Bin Alaudin, Chua Siang Meng, Heng Paul Wan Sia
A study of the impact of excipient shielding on initial drug release using UV imaging
International Journal of Pharmaceutics 2018: 553 (1-2): 229-237
Veronica Natalia, Goh Hui Ping, Kang Christina Yong Xin, Liew Celine Valeria, Heng Paul Wan Sia
Influence of spray nozzle aperture during high shear wet granulation on granule properties and its compression attributes
International Journal of Pharmaceutics 2018: 553 (1-2):474-482
Desai Parind Mahendrakumar, Anbalagan Parthiban, Koh Cheryl JN, Heng Paul Wan Sia, Liew Celine Valeria
Evaluation of tablet punch configuration on mitigating capping by a quality by design approach
Drug Delivery and Translational Research 2018: 8 (6): 1635-1643
Goh Hui Ping, Heng Paul Wan Sia, Liew Celine Valeria
Investigation on the impact of powder arching in small die filling
International Journal of Pharmaceutics 2018: 551 (1-2): 42-51
Heng Paul Wan Sia
Controlled release drug delivery systems
Pharmaceutical Development and Technology 2018: 23 (9): 833
Goh Hui Ping, Heng Paul Wan Sia, Liew Celine Valeria
Understanding effects of process parameters and forced feeding on die filling
European Journal of Pharmaceutical Sciences 2018: 122: 105-115
Paul Shubhajit, Heng Paul Wan Sia, Chan Lai Wah
Improvement in dissolution rate and photodynamic efficacy of chlorin e6 by sucrose esters as drug carrier in nanosuspension formulation: optimisation and in vitro characterisation Journal of Pharmacy and Pharmacology 2018: 70 (9):1152-1163
Tan David Cheng Thiam, Ong Jeremy Jianming, Gokhale Rajeev, Heng Paul Wan Sia
Hot melt extrusion of ion-exchange resin for taste masking
International Journal of Pharmaceutics 2018: 547 (1-2): 385-394
Goh Hui Ping, Heng Paul Wan Sia, Liew Celine Valeria
Comparative evaluation of powder flow parameters with reference to particle size and shape
International Journal of Pharmaceutics 2018: 547 (1-2): 133-141
Tay Justin Yong Soon, Liew Celine Valeria, Heng Paul Wan Sia
Dissolution of fine particle fraction from truncated Anderson cascade impactor with an enhancer cell
International Journal of Pharmaceutics 2018: 545 (1-2):45-50
Ouyang Hongyi, Zheng Audrey Yi, Heng Paul Wan Sia, Chan Lai Wah
Effect of lipid additives and drug on the rheological properties of molten paraffin wax, degree of surface drug coating, and drug release in spray-congealed microparticles
Pharmaceutics 2018: 10 (3): art. no. 75
Tan Bernice Mei Jin, Chan Lai Wah, Heng Paul Wan Sia
Characterizing the surface roughness length scales of lactose carrier particles in dry powder inhalers
Molecular Pharmaceutics 2018: 15(4): 1635-1642
Pham Van Quyet, Tan Bernice Mei Jin, Liew Celine Valeria, Chan Lai Wah, Ng Quan Sing, Heng Paul Wan Sia
Equilibria, kinetics and mechanism for the degradation of the cytotoxic compound L-NG-nitroarginine
Drug Development and Industrial Pharmacy 2018: 44(4): 624-631
Siow Carin Ru Shan, Heng Paul Wan Sia, Chan Lai Wah
Bulk Freeze-Drying Milling: a Versatile Method of Developing Highly Porous Cushioning Excipients for Compacted Multiple-Unit Pellet Systems (MUPS)
AAPS PharmSciTech 2018 : 19 (2): 845-857
2017
Goh Hui Ping, Heng Paul Wan Sia, Liew Celine Valeria
Understanding die fill variation during mini-tablet production
International Journal of Pharmaceutics 2017: 534 (1-2): 279-286
Kaewbanjong Jarika, Heng Paul Wan Sia, Prapaporn Boonme
Clotrimazole microemulsion and microemulsion-based gel: evaluation of buccal drug delivery and irritancy using chick chorioallantoic membrane as the model
Journal of Pharmacy and Pharmacology 2017: 69 (12): 1716-1723.
Rutthapol Sritharadol, Titpawan Nakpheng, Heng Paul Wan Sia Heng, Teerapol Srichana
Development of a topical mupirocin spray for antibacterial and wound-healing applications
Drug Development and Industrial Pharmacy 2017: 43 (10): 1715-1728.
Tay Justin Yong Soon, Liew Celine Valeria, Heng Paul Wan Sia
Powder Flow Testing: Judicious Choice of Test Methods
AAPS PharmSciTech 2017: 18 (5): 1843-1854.
Anbalagan Parthiban, Heng Paul Wan Sia, Liew Celine Valeria
Tablet compression tooling – Impact of punch face edge modification
International Journal of Pharmaceutics 2017, 524 (1-2): 373-381.
Anbalagan Parthiban, Liew Celine Valeria, Heng Paul Wan Sia
Role of dwell on compact deformation during tableting: an overview
Journal of Pharmaceutical Investigation 2017: 47 (3): 173-181.
Ong Kheng Yong, Lim Wei Ching, Ooi Shing Ming, Loh Zhi Hui, Kong Ming Chai, Chan Lai Wah, Heng Paul Wan Sia
Stability of a novel corticosteroid nasal irrigation solution: betamethasone 17-valerate added to extemporaneously prepared nasal irrigation solutions
International Forum of Allergy and Rhinology 2017: 7 (5): 494-501.
Kou Xiang, Chan Lai Wah, Sun Changquan Calvin, Heng Paul Wan Sia
Preparation of slab-shaped lactose carrier particles for dry powder inhalers by air jet milling
Asian Journal of Pharmaceutical Sciences 2017: 12 (1): 59-65.
2016
Siow Carin Ru Shan, Heng Paul Wan Sia, Chan Lai Wah
Application of freeze-drying in the development of oral drug delivery systems
Expert Opinion on Drug Delivery 2016: 13 (11):1595-1608.
Kou Xiang, Wereley Steven T, Heng Paul Wan Sia, Chan Lai Wah, Carvajal M Teresa
Powder dispersion mechanisms within a dry powder inhaler using microscale particle image velocimetry
International Journal of Pharmaceutics 2016: 514 (2): 445-455.
Hiew Tze Ning, Johan Binte Nur Atiqah, Desai Parind Mahendrakumar, Chua Siang Meng, Loh Zhi Hui, Heng Paul Wan Sia
Effect of moisture sorption on the performance of crospovidone
International Journal of Pharmaceutics 2016: 514(1): 322-331
Desai Parind Mahendrakumar, Liew Celine Valeria, Heng Paul Wan Sia
Review of Disintegrants and the Disintegration Phenomena
Journal of Pharmaceutical Sciences 2016: 105 (9): 2545-2555.
Tan Bernice Mei Jin, Chan Lai Wah, Heng Paul Wan Sia
Improving Dry Powder Inhaler Performance by Surface Roughening of Lactose Carrier Particles
Pharmaceutical Research 2016: 33 (8): 1923-1935.
Wong Priscilla Chui Hong, Heng Paul Wan Sia, Chan Lai Wah
Viscosity–temperature relationship of lipid-based excipients amenable for spray congealing: Derivation of a rheological parameter with good correlation to particle size
European Journal of Lipid Science and Technology 2016: 118 (7):1062-1073.
Tan Bernice Mei Jin, Chan Lai Wah, Heng Paul Wan Sia
Determination of the Nip Angle in Roller Compactors with Serrated Rolls
Journal of Pharmaceutical Sciences 2016: 105 (6): 1967-1975.
Paul Shubhajit, Heng Paul Wan Sia, Chan Lai Wah
PH-dependent complexation of hydroxypropyl-beta-cyclodextrin with chlorin e6: Effect on solubility and aggregation in relation to photodynamic efficacy
Journal of Pharmacy and Pharmacology 2016: 68 (4): 439-449.
Xu Min, Heng Paul Wan Sia, Liew Celine Valeria
Formulation and process strategies to minimize coat damage for compaction of coated pellets in a rotary tablet press: A mechanistic view
International Journal of Pharmaceutics 2016: 499 (1-2): 29-37.
Chin Wun Chyi, Chan Lai Wah, Heng Paul Wan Sia
A mechanistic investigation on the utilization of lactose as a protective agent for multi-unit pellet systems
Pharmaceutical Development and Technology 2016: 21 (2): 222-230.
Heng Paul Wan Sia
Compaction of coated multi-particulates
Asian Journal of Pharmaceutical Sciences 2016: 11 (1): 12-13.
Sheon Chan Pui, Nallamolu Sivaram, Heng Paul Wan Sia
A study on the plasticization of sustained release coatings for their ability to withstand the damaging effects of compaction on coated pellets
Asian Journal of Pharmaceutical Sciences 2016: 11 (1): 209-210.
Wong Priscilla Chui Hong, Heng Paul Wan Sia, Chan Lai Wah
A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen
Drug Development and Industrial Pharmacy 2016: 42 (3): 364-377.
Oh Ching Mien, Siow Carin Ru Shan, Heng Paul Wan Sia, Chan Lai Wah
Impact of HPMC on the physical properties of spray-congealed PEG microparticles and its swelling effect on rifampicin dissolution
Drug Development and Industrial Pharmacy 2016: 42 (3): 403-411.
Li Xiao, Xu De Sheng, Li Min, Liu Li, Heng Paul Wan Sia
Preparation of co-spray dried cushioning agent containing stearic acid for protecting pellet coatings when compressed
Drug Development and Industrial Pharmacy 2016: 42 (5): 788-795
2015
Inguva Pavan K, Ooi Shing Ming, Desai Parind Mahendrakumar, Heng Paul Wan Sia
Encapsulation of volatiles by homogenized partially-cross linked alginates
International Journal of Pharmaceutics 2015:496 (2):709-716.
Oh Ching Mien, Heng Paul Wan Sia, Chan Lai Wah
Influence of Hydroxypropyl Methylcellulose on Metronidazole Crystallinity in Spray-Congealed Polyethylene Glycol Microparticles and Its Impact with Various Additives on Metronidazole Release
AAPS PharmSciTech 2015: 16 (6): 1357-1367.
Wong Priscilla Chui Hong, Heng Paul Wan Sia, Chan Lai Wah
Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: The effect of matrix type, polymeric additives and drug-matrix miscibility
Journal of Microencapsulation 2015: 32 (8): 725-736.
Wong Priscilla Chui Hong, Heng Paul Wan Sia, Chan Lai Wah
Determination of solid state characteristics of spray-congealed ibuprofen solid lipid microparticles and their impact on sustaining drug release
Molecular Pharmaceutics 2015: 12 (5): 1592-1604.
Xu Min, Liew Celine Valeria, Heng Paul Wan Sia
Evaluation of the coat quality of sustained release pellets by individual pellet dissolution methodology
International Journal of Pharmaceutics 2015: 478 (1): 318-327.
Sarkar Srimanta, Ooi Shing Ming, Liew Celine Valeria, Heng Paul Wan Sia
Influence of Rate of Force Application During Compression on Tablet Capping
Journal of Pharmaceutical Sciences 2015: 104 (4): 1319-1327.
Wang Likun, Heng Paul Wan Sia, Liew Celine Valeria
Cluster Formation and Drag Reduction – Proposed Mechanism of Particle Recirculation within the Partition Column of the Bottom Spray Fluid-Bed Coater
Journal of Pharmaceutical Sciences 2015: 104 (4), 1303-1310.
Xu Min, Liew Celine Valeria, Heng Paul Wan Sia
Evaluation of the coat quality of sustained release pellets by individual pellet dissolution methodology
International Journal of Pharmaceutics 2015: 478 (1): 318-327.
Cahyadi Christine, Chan Lai Wah, Heng Paul Wan Sia
A comparative study between conventional pan coater and quasi-continuous small batch coater on the stability of tablets containing acetylsalicylic acid
European Journal of Pharmaceutics and Biopharmaceutics 2015: 90, 30-37.
Soh Josephine Lay Peng, Liew Celine Valeria, Heng Paul Wan Sia
Impact of excipient variability on drug product processing and performance
Current Pharmaceutical Design 2015: 21 (40): 5890-5899.
Rathore Sweta, Heng Paul Wan Sia, Chan Lai Wah
Microencapsulation of Clostridium acetobutylicum ATCC 824 spores in gellan gum microspheres for the production of biobutanol
Journal of Microencapsulation 2015: 32 (3): 290-299.
Desai Parind Mahendrakumar, Tan Bernice Mei Jin, Liew Celine Valeria, Chan Lai Wah, Heng Paul Wan Sia
Impact of electrostatics on processing and product performance of pharmaceutical solids
Current Pharmaceutical Design 2015: 21 (40): 5923-5929.
Tan Bernice Mei Jin, Tay Justin Yong Soon, Wong Poh Mun, Chan Lai Wah, Heng Paul Wan Sia
Investigation of the milling capabilities of the F10 Fine Grind mill using Box-Behnken designs
European Journal of Pharmaceutics and Biopharmaceutics 2015: 89: 208-215.
Oh Ching Mien, Heng Paul Wan Sia, Chan Lai Wah
A Study on the Impact of Hydroxypropyl Methylcellulose on the Viscosity of PEG Melt Suspensions Using Surface Plots and Principal Component Analysis
AAPS PharmSciTech 2015: 16(2): 466-477.
2014
Waché Yves, Anal Anil Kumar, Chan Eng Seng, Heng Paul Wan Sia, Ngo Dang N Ghia, In Sokneang, Poncelet Denis, Phan-Thi Hanh
Meeting report: the 1st BRG-training school in Asia, a first step in the building of an ASEAN encapsulation network
Biotechnology journal 2014: 9 (12):1473-1475.
Sarkar Srimanta, Ooi Shing Ming, Liew Celine Valeria, Tan Bing Xun, Heng Paul Wan Sia
Influence of disintegrants in different substrate physical form on dimensional recovery of multi-component tablet
International Journal of Pharmaceutics 2014: 475 (1): 558-565.
Loh Zhi Hui, Samanta Asim Kumar, Heng Paul Wan Sia
Overview of milling techniques for improving the solubility of poorly water-soluble drugs
Asian Journal of Pharmaceutical Sciences 2014: 10 (4): 255-274.
Paul Shubhajit, Heng Paul Wan Sia, Chan Lai Wah
Elucidating chlorin e6-sucrose ester interaction using coarse-grain modeling and fluorescence spectroscopic technique
Colloids and Surfaces A: Physicochemical and Engineering Aspects 2014: 451 (1): 125-135.
Rathore Sweta, Heng Paul Wan Sia, Chan Lai Wah
Feasibility study on microencapsulation of anaerobic Clostridium acetobutylicum ATCC 824 by emulsification method for application in biobutanol production
Journal of Microencapsulation 2014: 31 (5): 469-478.
Desai Parind Mahendrakumar, Er Patrick Xuan Hua, Liew Celine Valeria, Heng Paul Wan Sia
Functionality of disintegrants and their mixtures in enabling fast disintegration of tablets by a quality by design approach
AAPS PharmSciTech 2014: 15 (5): 1093-1104.
Sarkar Srimanta, Liew Celine Valeria
Moistening Liquid-Dependent De-aggregation of Microcrystalline Cellulose and Its Impact on Pellet Formation by Extrusion-Spheronization
AAPS PharmSciTech 2014; 15 (3): 753-761.
Sarkar Srimanta, Ang Bee Hwee, Liew Celine Valeria
Influence of starting material particle size on pellet surface roughness
AAPS PharmSciTech 2014: 15 (1): 131-139.
Samanta Asim Kumar, Wang Likun, Ng Ka Yun, Heng Paul Wan Sia
Energy-based analysis of cone milling process for the comminution of roller compacted flakes
International Journal of Pharmaceutics 2014; 462 (1-2): 108-114.
Li Wenji, Ng Ka Yun, Heng Paul Wan Sia
Development and evaluation of optimized sucrose ester stabilized oleanolic acid nanosuspensions prepared by wet ball milling with design of experiments
Biological and Pharmaceutical Bulletin 2014, 37 (6): 926-937.
Chutoprapat Romchat, Chan Lai Wah, Heng Paul Wan Sia
Ex-vivo permeation study of chlorin e6-polyvinylpyrrolidone complexes through the chick chorioallantoic membrane model
Journal of Pharmacy and Pharmacology 2014; 66 (7): 943-953.
Oh Ching Mien, Guo Qiyun, Heng Paul Wan Sia, Chan Lai Wah
Spray-congealed microparticles for drug delivery-an overview of factors influencing their production and characteristics
Expert Opinion on Drug Delivery 2014; 11 (7): 1047-1060.
Tan Bernice Mei Jin, Loh Zhi Hui, Soh Josephine Lay Peng, Liew Celine Valeria, Heng Paul Wan Sia
Distribution of a viscous binder during high shear granulation – Sensitivity to the method of delivery and its impact on product properties
International Journal of Pharmaceutics 2014; 460 (1-2): 255-263.
2013
Sarkar Srimanta, Wong Tin Wui, Liew Celine Valeria
Importance of wet packability of component particles in pellet formation
AAPS PharmSciTech 2013; 14 (3): 1267-1277.
Sia Chong Hock, Robert M Tribe, Chan Lai Wah
ASEAN harmonization on GMP inspection and training of inspectors
Pharmaceutical Engineering 2013; 33 (1): 56-62.
Paul Shubhajit, Selvam Susithra Mahalaxmi, Heng Paul Wan Sia, Chan Lai Wah
Elucidation of monomerization effect of PVP on chlorin e6 aggregates by spectroscopic, chemometric, thermodynamic and molecular simulation studies
Journal of Fluorescence 2013; 23 (5): 1065-1076.
Ooi Shing Ming, Sarkar Srimanta, Van Varenbergh Griet, Schoeters Kris, Heng Paul Wan Sia
Continuous processing and the applications of online tools in pharmaceutical product manufacture: Developments and examples.
Therapeutic Delivery 2013; 4 (4): 463-470.
Pham Van Quyet, Samanta Asim Kumar, Liew Celine Valeria, Chan Lai Wah, Heng Paul Wan Sia
A prediction model for monitoring ribbed roller compacted ribbons
Journal of Pharmaceutical Sciences 2013; 102 (8): 2667-2678.
Soh Josephine Lay Peng, Sarkar Srimanta, Heng Paul Wan Sia, Liew Celine Valeria
Pelletization Techniques – An overview.
Encyclopedia of Pharmaceutical Science and Technology, 4th Edition.
Sarkar Srimanta, Heng Paul Wan Sia, Liew Celine Valeria
Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization.
Pharmaceutical Development and Technology 2013; 18(1):61-72.
Paul Shubhajit, Heng Paul Wan Sia, Chan Lai Wah
Optimization in solvent selection for chlorin e6 in photodynamic therapy.
Journal of Fluorescence 2013; 23(2):283-291.
Desai Parind Mahendrakumar, Liew Celine Valeria, Heng Paul Wan Sia
Assessment of disintegration of rapidly disintegrating tablets by a visiometric liquid jet-mediated disintegration apparatus.
International Journal of Pharmaceutics 2013; 442 (1-2):65-73.
Rathore Sweta, Desai Parind Mahendrakumar, Liew Celine Valeria, Chan Lai Wah, Heng Paul Wan Sia
Microencapsulation of microbial cells.
Journal of Food Engineering 2013; 116 (2): 369-381.
Cahyadi Christine, Chan Lai Wah, Heng Paul Wan Sia
The reality of in-line tablet coating.
Pharmaceutical Development and Technology 2013; 18(1):2-16.
Wong Poh Mun, Chan Lai Wah, Heng Paul Wan Sia
Investigation on side-spray fluidized bed granulation with swirling airflow.
AAPS PharmSciTech 2013; 14 (1): 211-221.
Samanta Asim Kumar, Karande Atul D, Ng Ka Yun, Heng Paul Wan Sia
Application of near-infrared spectroscopy in real-time monitoring of product attributes of ribbed roller compacted flakes.
AAPS PharmSciTech 2013; 14(1):86-100.
2012
Cahyadi Christine, Koh Jackson Jie Sheng, Loh Zhi Hui, Chan Lai Wah, Heng Paul Wan Sia
A feasibility study on pellet coating using a high-speed quasi-continuous coater.
AAPS PharmSciTech 2013; 13 (4):1276-1286.
Chan Lai Wah, Sia Chong Hock, Tan Kiat Yun
Current Scientific Status and Regulatory Control of Traditional/Herbal Medicinal Products: Globalization Challenges
Pharmaceutical Engineering 2012; 32 (6) : 10 – 20.
Desai Parind Mahendrakumar, Liew Celine Valeria, Heng Paul Wan Sia
Understanding disintegrant action by visualization.
Journal of Pharmaceutical Sciences 2012; 101 (6):2155-2164.
Cahyadi Christine, Tan Bing Xun, Chan Lai Wah, Heng Paul Wan Sia
A study on in-line tablet coating-the influence of compaction and coating on tablet dimensional changes.
AAPS PharmSciTech 2012; 13 (3) : 785 – 792.
Tay Stephanie Li Mei, Heng Paul Wan Sia, Chan Lai Wah
The CAM-LDPI method: A novel platform for the assessment of drug absorption.
Journal of Pharmacy and Pharmacology 2012; 64 (4):517-529.
Tay Stephanie Li Mei, Heng Paul Wan Sia, Chan Lai Wah
The chick chorioallantoic membrane imaging method as a platform to evaluate vasoactivity and assess irritancy of compounds.
Journal of Pharmacy and Pharmacology 2012. Article in Press.
Bruno Lilia, Kasapis Stefan, Heng Paul Wan Sia
Effect of polymer molecular weight on the structural properties of non aqueous ethyl cellulose gels intended for topical drug delivery.
Carbohydrate Polymers 2012; 88 (1):382-388.
Goh Cheong Hian, Heng Paul Wan Sia, Chan Lai Wah
Alginates as a useful natural polymer for microencapsulation and therapeutic applications.
Carbohydrate Polymers 2012; 88 (1):1-12.
Kou Xiang, Chan Lai Wah, Steckel Hartwig, Heng Paul Wan Sia
Physico-chemical aspects of lactose for inhalation.
Advanced Drug Delivery Reviews 2012; 64 (3):220-232.
Bruno Lilia, Kasapis Stefan, Heng Paul Wan Sia
Effect of hydration on the structure of non aqueous ethyl cellulose/propylene glycol dicaprylate gels.
International Journal of Biological Macromolecules 2012; 50 (2):385-392.
Samanta Asim Kumar, Ng Ka Yun, Heng Paul Wan Sia
Cone milling of compacted flakes: Process parameter selection by adopting the minimal fines approach.
International Journal of Pharmaceutics 2012; 422 (1-2):17-23.
Goh Cheong Hian, Heng Paul Wan Sia, Chan Lai Wah
Cross-linker and non-gelling Na + effects on multi-functional alginate dressings.
Carbohydrate Polymers 2012; 87 (2):1796-1802.
Sia Chong Hock, Neo Constance Xue Rui, Chan Lai Wah
Toward higher QA: From parametric release of sterile parenteral products to PAT for other pharmaceutical dosage forms
PDA Journal of Pharmaceutical Science and Technology 2012; 66 (4): 371-391.
2011
Sia Chong Hock, Yan Mei Ying, Chan Lai Wah
A Review of the Current Scientific and Regulatory Status of Nanomedicines and the Challenges Ahead
PDA Journal of Pharmaceutical Science and Technology 2011; 65:177-195.
Tan Sook Mun, Heng Paul Wan Sia, Chan Lai Wah
Development of re-usable yeast-gellan gum micro-bioreactors for potential application in continuous fermentation to produce bio-ethanol.
Pharmaceutics 2011; 3 (4):731-744.
Loh Zhi Hui, Er Dawn Zhi Lin, Chan Lai Wah, Liew Celine Valeria, Heng Paul Wan Sia
Spray granulation for drug formulation.
Expert Opinion on Drug Delivery 2011; 8 (12):1645-1661.
Loh Zhi Hui, Sia BengYi, Heng Paul Wan Sia, Lee Chin Chiat, Liew Celine Valeria
Evaluation of the physicochemical properties and compaction behavior of melt granules produced in microwave-induced and conventional melt granulation in a single pot high shear processor.
AAPS PharmSciTech 2011; 12 (4):1374-1383.
Ha Minh Hien, Heng Paul Wan Sia, Nguyen Van Thi, Nguyen Khac Quynh Cu, Vo Thi Bach Hue
Development and validation of a GC-MS method for rapid determination of calophyllolide in Calophyllum inophyllum L.: A quality control approach.
Chinese Journal of Natural Medicines 2011; 9 (6):429-434.
Lin Xiao, Chin Wun Chyi, Ruan KeFeng, Feng Yi, Heng Paul Wan Sia
Development of potential novel cushioning agents for the compaction of coated multi-particulates by co-processing micronized lactose with polymers.
European Journal of Pharmaceutics and Biopharmaceutics 2011; 79 (2):406-415.
Tay Stephanie Li Mei, Heng Paul Wan Sia, Chan Lai Wah
An investigation of the chick chorioallantoic membrane as an alternative model to various biological tissues for permeation studies.
Journal of Pharmacy and Pharmacology 2011; 63 (10):1283-1289.
Ma Xiang, Tan Soo Tong, Khoo Chai Ling, Sim Hong May, Chan Lai Wah, Chui Wai Keong
Synthesis and antimicrobial activity of N 1-benzyl or N 1-benzyloxy-1,6-dihydro-1,3,5-triazine-2,4-diamines.
Bioorganic and Medicinal Chemistry Letters 2011; 21 (18):5428-5431.
Bruno Lilia, Kasapis Stefan, Chaudhary Vinita, Chow Keat Theng, Heng Paul Wan Sia, Leong Lai Peng
Temperature and time effects on the structural properties of a non-aqueous ethyl cellulose topical drug delivery system.
Carbohydrate Polymers 2011; 86 (2):644-651.
Li WenJi, Das Surajit, Ng Ka Yun, Heng Paul Wan Sia
Formulation, biological and pharmacokinetic studies of sucrose ester-stabilized nanosuspensions of oleanolic acid.
Pharmaceutical Research 2011; 28 (8):2020-2033.
Cahyadi Christine, Chan Lai Wah, Colombo Paolo, Heng Paul Wan Sia
The butterfly effect: A physical phenomenon of hypromellose matrices during dissolution and the factors affecting its occurrence.
International Journal of Pharmaceutics 2011; 406 (1-2):31-40.
Cahyadi Christine, Heng Paul Wan Sia, Chan Lai Wah
Optimization of process parameters for a quasi-continuous tablet coating system using design of experiments.
AAPS PharmSciTech 2011; 12 (1):119-131.
2010
Chin William Wei Lim, Praveen Thoniyot, Heng Paul Wan Sia, Olivo Malini
Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization.
European Journal of Pharmaceutics and Biopharmaceutics 2010; 76 (2):245-252.
Cahyadi Christine, Karande Atul D, Chan Lai Wah, Heng Paul Wan Sia
Comparative study of non-destructive methods to quantify thickness of tablet coatings.
International Journal of Pharmaceutics 2012; 398 (1-2):39-49.
Wang LiKun, Heng Paul Wan Sia, Liew Celine Valeria
Online monitoring of particle mass flow rate in bottom spray fluid bed coating-Development and application.
International Journal of Pharmaceutics 2010; 395 (1-2):215-221.
Karande Atul D, Heng Paul Wan Sia, Liew Celine Valeria
In-line quantification of micronized drug and excipients in tablets by near infrared (NIR) spectroscopy: Real time monitoring of tabletting process.
International Journal of Pharmaceutics 2010; 396 (1-2):63-74.
Karande Atul D, Liew Celine Valeria, Heng Paul Wan Sia
Calibration sampling paradox in near infrared spectroscopy: A case study of multi-component powder blend.
International Journal of Pharmaceutics 2010; 395 (1-2):91-97.
Wang LiKun, Heng Paul Wan Sia, Liew Celine Valeria
Classification of annular bed flow patterns and investigation on their influence on the bottom spray fluid bed coating process.
Pharmaceutical Research 2010; 27 (5):756-766.
Cheah Emily Li Chin, Heng Paul Wan Sia, Chan Lai Wah
Optimization of supercritical fluid extraction and pressurized liquid extraction of active principles from Magnolia officinalis using the Taguchi design.
Separation and Purification Technology 2010; 71 (3):293-301.
Liew Celine Valeria, Karande Atul D, Heng Paul Wan Sia
In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy.
International Journal of Pharmaceutics 2010; 386 (1-2):138-148.
Heng Paul Wan Sia, Loh Zhi Hui, Liew Celine Valeria, Lee Chin Chiat
Dielectric properties of pharmaceutical materials relevant to microwave processing: Effects of field frequency, material density, and moisture content.
Journal of Pharmaceutical Sciences 2010; 99 (2):941-957.
Liew Celine Valeria, Wang LiKun, Heng Paul Wan Sia
Development of a visiometric process analyzer for real-time monitoring of bottom spray fluid-bed coating.
Journal of Pharmaceutical Sciences 2010; 99 (1):346-356.
2009
Nair A. Sreekumaran, Binoy Nadappuram P, Ramakrishna Seeram, Kurup T R Ramachandra, Chan Lai Wah, Goh Cheong Hian, Islam Md Rafiqul, Utschig Thomas, PradeepThalappil
Organic-soluble antimicrobial silver nanoparticle-polymer composites in gram scale by one-pot synthesis.
ACS Applied Materials and Interfaces 2009; 1 (11): 2413-2419.
Tan Lay Hui, Chan Lai Wah, Heng Paul Wan Sia
Alginate/starch composites as wall material to achieve microencapsulation with high oil loading.
Journal of Microencapsulation 2009; 26 (3): 263-271.
Liew Celine Valeria, Er Dawn Zhi Lin, Heng Paul Wan Sia
Air-dictated bottom spray process: impact of fluid dynamics on granule growth and morphology.
Drug development and industrial pharmacy 2009; 35(7):866-76.
Er Dawn Zhi Lin, Liew Celine Valeria, Heng Paul Wan Sia
Layered growth with bottom-spray granulation for spray deposition of drug.
International journal of pharmaceutics 2009; 377(1-2):16-24.
Liu Jun, Saw Constance Lay Lay, Olivo Malini, Sudhaharan Thankiah, Ahmed Sohail, Heng Paul Wan Sia, Wohland Thorsten
Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques.
Journal of biomedical optics 2009; 14(1):014003.
Chin William Wei Lim, Thong Patricia S P, Bhuvaneswari Ramaswamy, Soo Khee Chee, Heng Paul Wan Sia, Olivo Malini
In-vivo optical detection of cancer using chlorin e6–polyvinylpyrrolidone induced fluorescence imaging and spectroscopy.
BMC medical imaging 2009; 9:1.
2008
Chow Keat Theng, Zhu Kewu, Tan Reginald B H, Heng Paul Wan Sia
Investigation of electrostatic behavior of a lactose carrier for dry powder inhalers.
Pharmaceutical research 2008; 25(12):2822-34.
Saw Constance Lay Lay, Heng Paul Wan Sia, Liew Celine Valeria
Chick chorioallantoic membrane as an in situ biological membrane for pharmaceutical formulation development: a review.
Drug development and industrial pharmacy 2008; 34(11):1168-77.
Zhu Kewu, Ng Wai Kiong, Shen Shoucang, Tan Reginald B H, Heng Paul Wan Sia
Design of a device for simultaneous particle size and electrostatic charge measurement of inhalation drugs.
Pharmaceutical research 2008; 25(11):2488-96.
Chin William Wei Lim, Heng Paul Wan Sia, Lim Pei Li, Lau Weber Kam On, Olivo Malini
Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model.
Journal of biophotonics 2008; 1(5):395-407.
Chin William Wei Lim, Heng Paul Wan Sia, Thong Patricia Soo Ping, Bhuvaneswari Ramaswamy, Hirt Werner, Kuenzel Sebastian, Soo Khee Chee, Olivo Malini
Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer.
European journal of pharmaceutics and biopharmaceutics 2008; 69(3):1083-93.
Chow Keat Theng, Chan Lai Wah, Heng Paul Wan Sia
Characterization of spreadability of nonaqueous ethylcellulose gel matrices using dynamic contact angle.
Journal of pharmaceutical sciences 2008; 97(8):3467-82.
Loh Zhi Hui, Liew Celine Valeria, Lee Chin Chiat, Heng Paul Wan Sia
Microwave-assisted drying of pharmaceutical granules and its impact on drug stability.
International journal of pharmaceutics 2008; 359(1-2):53-62.
Goh Cheong Hian, Heng Paul Wan Sia, Huang Esther Pei En, Li Benny Kai Hui, Chan Lai Wah
Interactions of antimicrobial compounds with cross-linking agents of alginate dressings.
The Journal of antimicrobial chemotherapy 2008; 62(1):105-8.
Ching Ai Ling, Liew Celine Valeria, Heng Paul Wan Sia, Chan Lai Wah
Impact of cross-linker on alginate matrix integrity and drug release.
International journal of pharmaceutics 2008; 355(1-2):259-68.
Wang Chao, Chen Fei, Heng Paul Wan Sia, Li Ji-Zhong, Li Xiang, Ye Guan-Hao, Nie Shu-Fang, Pan Wei-San
A novel time-controlled release system based on drug-resin complexes and elementary osmotic pump.
Chemical & pharmaceutical bulletin 2008; 56(4):457-63.
Ching Ai Ling, Liew Celine Valeria, Chan Lai Wah, Heng Paul Wan Sia
Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2008; 33(4-5):361-70.
Lee Chin Chiat, Ong Charlene Li Ching, Heng Paul Wan Sia, Chan Lai Wah, Wong Tin Wui
Interactive mixture as a rapid drug delivery system.
Drug development and industrial pharmacy 2008; 34(2):206-14.
Tang Elaine Sook Khay, Wang Likun, Liew Celine Valeria, Chan Lai Wah, Heng Paul Wan Sia
Drying efficiency and particle movement in coating–impact on particle agglomeration and yield.
International journal of pharmaceutics 2008; 350(1-2):172-80.
Wang Siling, Ye Guanhao, Heng Paul Wan Sia, Ma Mingxin
Investigation of high shear wet granulation processes using different parameters and formulations.
Chemical & pharmaceutical bulletin 2008; 56(1):22-7.
Chow Keat Theng, Chan Lai Wah, Heng Paul Wan Sia
Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices.
Pharmaceutical research 2008; 25(1):207-17.
Liew Celine Valeria, Loh Zhi Hui, Heng Paul Wan Sia, Lee Chin Chiat
A study on microwave-induced melt granulation in a single pot high shear processor.
Pharmaceutical development and technology 2008; 13(5):401-11.
Soh Josephine Lay Peng, Yang Lei, Liew Celine Valeria, Cui Fu De, Heng Paul Wan Sia
Importance of small pores in microcrystalline cellulose for controlling water distribution during extrusion-spheronization.
AAPS PharmSciTech 2008; 9(3):972-81.
Saw Constance Lay Lay, Heng Paul Wan Sia, Olivo Malini
Potentiation of the photodynamic action of hypericin.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 2008; 27(1):23-33.
Chan Lai Wah, Tan Lay Hui, Heng Paul Wan Sia
Process analytical technology: application to particle sizing in spray drying.
AAPS PharmSciTech 2008; 9(1):259-66.
Saw Constance Lay Lay, Olivo Malini, Soo Khee Chee, Heng Paul Wan Sia
Use of hypericin in photodynamic applications.
In: Govil J N, Singh V K, Sharma R Kr (Eds.), Recent progress in medicinal plants, Vol. 20. New Delhi: Studium Press LLC.
Saw Constance Lay Lay, Heng Paul Wan Sia
Hypericin.
In: Schwab M (Ed). Encyclopedia of cancer, 2nd ed. Chicago: Springer.
2007
Saw Constance Lay Lay, Olivo Malini, Wohland Thorsten, Fu Chit Yaw, Kho Kiang Wei, Soo Khee Chee, Heng Paul Wan Sia
Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy.
Technology in cancer research & treatment 2007; 6(5):383-94.
Chan Lai Wah, Zhou Qi, Heng Paul Wan Sia
Comparison of surface roughness parameters obtained by scanning probe microscopy for carrier particles of dry powder inhalers.
Journal of drug delivery science & technology 2007; 17(3):217-222.
Chan Lai Wah, Ching Ai Ling, Liew Celine Valeria, Heng Paul Wan Sia
Mechanistic study on hydration and drug release behavior of sodium alginate compacts.
Drug development and industrial pharmacy 2007; 33(6):667-76.
Ye Guanhao, Wang Siling, Heng Paul Wan Sia, Chen Ling, Wang Chao
Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization.
International journal of pharmaceutics 2007; 337(1-2):80-7.
Saw Constance Lay Lay, Olivo Malini, Chin William Wei Lim, Soo Khee Chee, Heng Paul Wan Sia
Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model.
Journal of photochemistry and photobiology. B, Biology 2007; 86(3):207-18.
Zhu Kewu, Tan Reginald B H, Chen Fengxi, Ong Kunn Hadinoto, Heng Paul Wan Sia
Influence of particle wall adhesion on particle electrification in mixers.
International journal of pharmaceutics 2007; 328(1):22-34.
Chin William Wei Lim, Lau Weber Kam On, Bhuvaneswari Ramaswamy, Heng Paul Wan Sia, Olivo Malini
Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model.
Cancer letters 2007; 245(1-2):127-33.
Chin William Wei Lim, Heng Paul Wan Sia, Olivo Malini
Chlorin e6 – polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts.
BMC pharmacology 2007; 7:15.
Tang Elaine Sook Khay, Liew Celine Valeria, Er Dawn Zhi Lin, Liu Xiaohua, Wigmore Anthony J, Heng Paul Wan Sia
Study of coat quality of tablets coated by an on-line Supercell coater.
AAPS PharmSciTech 2007; 8(3):E63.
Cheong Wai See, Heng Paul Wan Sia, Wong Tin Wui
Impact of a non-meltable additive on melt agglomeration with a hydrophobic meltable binder in high-shear mixer.
Pharmaceutical development and technology 2007; 12(4):371-80.
Liew Celine Valeria, Chua Siang Meng; Heng Paul Wan Sia
Elucidation of spheroid formation with and without the extrusion step.
AAPS PharmSciTech 2007; 8(1):10.
Nair Sujit, Xu Changjiang, Shen Guoxiang, Hebbar Vidya, Gopalakrishnan Avantika, Hu Rong; Jain Mohit Raja, Liew Celine Valeria, Chan Jefferson Y, Kong Tony Ah-Ng
Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice
Toxicology Letters 2007; 168 (1):21-39.
2006
Lee Huey Ying, Chan Lai Wah, Dolzhenko Anton V, Heng Paul Wan Sia
Influence of viscosity and uronic acid composition of alginates on the properties of alginate films and microspheres produced by emulsification.
Journal of microencapsulation 2006; 23(8):912-27.
Heng Paul Wan Sia, Chan Lai Wah, Tang Elaine Sook Khay
Use of swirling airflow to enhance coating performance of bottom spray fluid bed coaters.
International journal of pharmaceutics 2006; 327(1-2):26-35.
Chin William Wei Lim, Heng Paul Wan Sia, Bhuvaneswari Ramaswamy, Lau Weber Kam On, Olivo Malini
The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy.
Photochemical & photobiological sciences 2006; 5(11):1031-7.
Saw Constance Lay Lay, Olivo Malini, Soo Khee Chee, Heng Paul Wan Sia
Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations.
Photochemical & photobiological sciences 2006; 5(11):1018-23.
Manivasager Vanaja, Yee Karen Kar Lye, Heng Paul Wan Sia, Soo Khee Chee, Olivo Malini
A study comparing endogenous protoporphyrin IX induced by 5-ALA and ALA-methyl ester with exogenous PpIX and PpIX dimethyl ester in photodynamic diagnosis of human nasopharyngeal carcinoma xenografts.
International journal of oncology 2006; 29(4): 997-1002.
Saw Constance Lay Lay, Olivo Malini, Soo Khee Chee, Heng Paul Wan Sia
Delivery of hypericin for photodynamic applications.
Cancer letters 2006; 241(1):23-30.
Chin William Wei Lim, Lau Weber Kam On, Heng Paul Wan Sia, Bhuvaneswari Ramaswamy, Olivo Malini
Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone.
Journal of photochemistry and photobiology. B, Biology 2006; 84(2):103-10.
Saw Constance Lay Lay, Heng Paul Wan Sia, Chin William Wei Lim, Soo Khee Chee, Olivo Malini
Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model.
Cancer letters 2006; 238(1):104-10.
Soh Josephine Lay Peng, Liew Celine Valeria, Heng Paul Wan Sia
Torque rheological parameters to predict pellet quality in extrusion-spheronization.
International journal of pharmaceutics 2006; 15(1-2):99-109.
Soh Josephine Lay Peng, Liew Celine Valeria, Heng Paul Wan Sia
New indices to characterize powder flow based on their avalanching behavior.
Pharmaceutical development and technology 2006; 11(1):93-102.
Chan Lai Wah, Chow Keat Theng, Heng Paul Wan Sia
Investigation of wetting behavior of nonaqueous ethylcellulose gel matrices using dynamic contact angle.
Pharmaceutical research 2006; 23(2):408-21.
Liew Celine Valeria, Chan Lai Wah, Ching Ai Ling, Heng Paul Wan Sia
Evaluation of sodium alginate as drug release modifier in matrix tablets.
International journal of pharmaceutics 2006; 309(1-2):25-37.
Chan Lai Wah, Tang Elaine Sook Khay, Heng Paul Wan Sia
Comparative study of the fluid dynamics of bottom spray fluid bed coaters.
AAPS PharmSciTech 2006; 7(2):E37.
Gu Li, Liew Celine Valeria, Soh Josephine Lay Peng, Heng Paul Wan Sia
Feasibility of eliminating premixing for the production of pellets in a rotary processor.
Pharmaceutical development and technology 2006; 11(2):159-65.
Nair Sujit, Xu Changjiang, Shen Guoxiang, Hebbar Vidya, Gopalakrishnan Avantika, Hu Rong, Jain Mohit Raja, Lin Wen, Keum Young Sam, Liew Celine Valeria, Chan Jefferson Y, Kong Tony Ah-Ng
Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.
Pharmaceutical research 2006; 23(11):2621-37.
Liu Xiaohua, Heng Paul Wan Sia, Li Qi, Chan Lai Wah
Novel polymeric microspheres containing norcantharidin for chemoembolization.
Journal of controlled release 2006; 116(1):35-41
Keum Young Sam, Han Yong Hae, Liew Celine Valeria, Kim Jung Hwan, Xu Changjiang, Yuan Xiaoling, Shakarjian Michael P, Chong Saeho, Kong Tony Ah-Ng
Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes.
Pharmaceutical Research 2006; 23(11):2586-94
Heng Paul Wan Sia, Wong Tin Wui
Melt processes for oral solid dosage forms.
In: Swarbrick J (Ed). Encyclopedia of pharmaceutical technology, 3rd ed. New York: Informa Healthcare
Cheah Emily Li Chin, Chan Lai Wah, Heng Paul Wan Sia
Supercritical carbon dioxide and its application in the extraction of active principles from plant materials.
Asian journal of pharmaceutical sciences 2006; 1(1):59-71.
Chan Lai Wah, Lee Huey Ying, Heng Paul Wan Sia
Mechanisms of external and internal gelation and their impact on the functions of alginate as a coat and delivery system.
Carbohydrate polymers 2006; 63(2): 176-187.
2005
Wong Tin Wui, Cheong Wai See, Heng Paul Wan Sia
Melt granulation and pelletization.
In: Parikh D M (Ed). 2nd ed. Handbook of pharmaceutical granulation technology, 2nd ed. Florida: Taylor & Francis.
Tang Elaine Sook Khay, Chan Lai Wah, Heng Paul Wan Sia
Coating of multiparticulates for sustained release.
American journal of drug delivery 2005; 3(1):17-28.
Dolzhenko Anton V, Chui Wai Keung, Dolzhenko Anna V, Chan Lai Wah
Synthesis and biological activity of fluorinated 2-amino-4-aryl-3,4 dihydro[1,3,5]triazino[1,2-a]benzimidazoles.
Journal of Fluorine Chemistry 2005; 126 (5): 759-763.
Heng Paul Wan Sia, Yolande Anthony, Lee Chin Chiat
Rapid release granulation.
In: Parikh D M (Ed). Handbook of pharmaceutical granulation technology, 2nd ed. Florida: Taylor & Francis.
Chan Lai Wah, Heng Paul Wan Sia
Drug substance and excipient characterization.
In: Parikh D M (Ed). Handbook of pharmaceutical granulation technology, 2nd ed. Florida: Taylor & Francis.
Chan Lai Wah, Liu Xiaohua, Heng Paul Wan Sia
Liquid phase coating to produce controlled-release alginate microspheres.
Journal of microencapsulation 2005; 22(8):891-900.
Liew Celine Valeria, Soh Josephine Lay Peng, Chen Fei, Shi Daming, Heng Paul Wan Sia
Application of multidimensional scaling to preformulation sciences: a discriminatory tool to group microcrystalline celluloses.
Chemical & pharmaceutical bulletin 2005; 53(10):1227-31.
Liew Celine Valeria, Gu Li, Soh Josephine Lay Peng, Heng Paul Wan Sia
Functionality of cross-linked polyvinylpyrrolidone as a spheronization aid: a promising alternative to microcrystalline cellulose.
Pharmaceutical research 2005; 22(8):1387-98.
Chee Sze Nam, Johansen Anne Lene, Gu Li, Karlsen Jan, Heng Paul Wan Sia
Microwave drying of granules containing a moisture-sensitive drug: a promising alternative to fluid bed and hot air oven drying.
Chemical & pharmaceutical bulletin 2005; 53(7):770-5.
Saw Constance Lay Lay, Olivo Malini, Chin William Wei Lim, Soo Khee Chee, Heng Paul Wan Sia
Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment.
Biological & pharmaceutical bulletin 2005; 28(6):1054-60.
Wong Tin Wui, Chan Lai Wah, Kho Shyan Bin, Heng Paul Wan Sia
Aging and microwave effects on alginate/chitosan matrices.
Journal of controlled release 2005; 104(3):461-75.
Lee Huey Ying, Chan Lai Wah, Heng Paul Wan Sia
Influence of partially cross-linked alginate used in the production of alginate microspheres by emulsification.
Journal of microencapsulation 2005; 22(3):275-80.
Tan Lay Hui, Chan Lai Wah, Heng Paul Wan Sia
Effect of oil loading on microspheres produced by spray drying.
Journal of microencapsulation 2005; 22(3):253-9.
Guo Qi Yun, Chan Lai Wah, Heng Paul Wan Sia
Investigation of the release of aspirin from spray-congealed micro-pellets.
Journal of microencapsulation 2005; 22(3):245-51.
Heng Paul Wan Sia, Chan Lai Wah, Chow Keat Theng
Development of novel nonaqueous ethylcellulose gel matrices: rheological and mechanical characterization.
Pharmaceutical research 2005; 22(4):676-84.
Chan Lai Wah, Ong Kang Teng, Heng Paul Wan Sia
Novel film modifiers to alter the physical properties of composite ethylcellulose films.
Pharmaceutical research 2005; 22(3):476-89.
Wang Mei Yin, Yang Yi Yan, Heng Paul Wan Sia
Skin permeation of physostigmine from fatty acids-based formulations: evaluating the choice of solvent.
International journal of pharmaceutics 2005; 290(1-2):25-36.
Wu Jing Yi, Liu Shao Qiong, Heng Paul Wan Sia, Yang Yi Yan
Evaluating proteins release from, and their interactions with, thermosensitive poly (N-isopropylacrylamide) hydrogels.
Journal of controlled release 2005; 102(2):361-72.
Hu Zeping, Yang Xiaoxia, Ho Paul Chi Lui, Chan Sui Yung, Heng Paul Wan Sia, Chan Eli, Duan Wei, Koh Hwee Ling, Zhou Shufeng
Herb-drug interactions: a literature review.
Drugs 2005; 65(9):1239-82.
2004
Soh Josephine Lay Peng, Chen Fei, Liew Celine Valeria, Shi Daming, Heng Paul Wan Sia
A novel preformulation tool to group microcrystalline celluloses using artificial neural network and data clustering.
Pharmaceutical research 2004; 21(12):2360-8.
Hao Jin Song, Chan Lai Wah, Shen Ze Xiang, Heng Paul Wan Sia
Complexation between PVP and Gantrez polymer and its effect on release and bioadhesive properties of the composite PVP/Gantrez films.
Pharmaceutical development and technology 2004; 9(4):379-86.
Tammilmani Vanaja, Yee Karen Kar Lye, Heng Paul Wan Sia, Soo Khee Chee, Olivo Malini
An evaluation of exogenous application of protoporphyrin IX and its dimethyl ester as a photodynamic diagnostic agent in poorly differentiated human nasopharyngeal carcinoma.
Photochemistry and photobiology 2004; 80(3):596-601.
Kwok Teresa Swee Har, Sunderland Bruce Vivian, Heng Paul Wan Sia
An investigation on the influence of a vinyl pyrrolidone/vinyl acetate copolymer on the moisture permeation, mechanical and adhesive properties of aqueous-based hydroxypropyl methylcellulose film coatings.
Chemical & pharmaceutical bulletin 2004; 52(7):790-6.
Heng Paul Wan Sia, Liew Celine Valeria, Soh Josephine Lay Peng
Pre-formulation studies on moisture absorption in microcrystalline cellulose using differential thermo-gravimetric analysis.
Chemical & pharmaceutical bulletin 2004; 52(4):384-90.
Heng Paul Wan Sia, Hao Jinsong, Chan Lai Wah, Chew Siok Hui
Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets.
Drug development and industrial pharmacy 2004; 30(2):213-20.
Gu Li, Liew Celine Valeria, Heng Paul Wan Sia
Wet spheronization by rotary processing–a multistage single-pot process for producing spheroids.
Drug development and industrial pharmacy 2004; 30(2):111-23.
Wang Mei Yin, Yang Yi Yan, Heng Paul Wan Sia
Role of solvent in interactions between fatty acids-based formulations and lipids in porcine stratum corneum.
Journal of controlled release 2004; 94(1):207-16.
Heng Paul Wan Sia, Chan Lai Wah, Liew Celine Valeria, Chee Sze Nam, Soh Josephine Lay Peng, Ooi Shing Ming
Roller compaction of crude plant material: influence of process variables, polyvinylpyrrolidone, and co-milling.
Pharmaceutical development and technology 2004; 9(2):135-44.
2003
Heng Paul Wan Sia, Chan Lai Wah, Ong Kang Teng
Influence of storage conditions and type of plasticizers on ethylcellulose and acrylate films formed from aqueous dispersions.
Journal of pharmacy & pharmaceutical sciences 2003; 6(3):334-44.
Hao Jinsong, Heng Paul Wan Sia
Buccal delivery systems.
Drug development and industrial pharmacy 2003; 29(8):821-32.
Heng Paul Wan Sia, Wong Tin Wui, Cheong Wai See
Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate.
European journal of pharmaceutical sciences 2003; 19(5):381-93.
Heng Paul Wan Sia, Chan Lai Wah, Wong Tin Wui
Formation of alginate microspheres produced using emulsification technique.
Journal of microencapsulation 2003; 20(3):401-13.
Chan Lai Wah, Lim Liang Theng, Heng Paul Wan Sia
Immobilization of fine particles on lactose carrier by precision coating and its effect on the performance of dry powder formulations.
Journal of pharmaceutical sciences 2003; 92(5):975-84.
Chan Lai Wah, Wong Tin Wui, Chua Pih Chng, York Peter, Heng Paul Wan Sia
Anti-tack action of polyvinylpyrrolidone on hydroxypropylmethylcellulose solution.
Chemical & pharmaceutical bulletin 2003; 51(2):107-12.
Manivasager Vanaja, Heng Paul Wan Sia, Hao Jinsong, Zheng Wei, Soo Khee Chee, Olivo Malini
A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer.
International journal of oncology 2003; 22(2):313-8.
Lee Chin Chiat, Chan Lai Wah, Heng Paul Wan Sia
Use of a fluidized bed hammer mill for size reduction and classification: effects of process variables and starting materials on the particle size distribution of milled lactose batches.
Pharmaceutical development and technology 2003; 8(4):431-42.
2002
Manivasager Vanaja, Heng Paul Wan Sia, Hao Jinsong, Zheng Wei, Soo Khee Chee, Olivo Malini
Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid.
International journal of oncology 2002; 21(5):1003-7.
Chan Lai Wah, Lee Chin Chiat, Heng Paul Wan Sia
Ultrafine grinding using a fluidized bed opposed jet mill: effects of feed load and rotational speed of classifier wheel on particle shape.
Drug development and industrial pharmacy 2002; 28(8):939-47.
Wong Tin Wui, Chan Lai Wah, Lee Huey Ying, Heng Paul Wan Sia
Release characteristics of pectin microspheres prepared by an emulsification technique.
Journal of microencapsulation 2002; 19(4):511-22.
Heng Paul Wan Sia, Liew Celine Valeria, Gu Li
Influence of teardrop studs on rotating frictional base plate on spheroid quality in rotary spheronization.
International journal of pharmaceutics 2002; 241(1):173-84.
Chan Lai Wah, Heng Paul Wan Sia
Effects of aldehydes and methods of cross-linking on properties of calcium alginate microspheres prepared by emulsification.
Biomaterials 2002; 23(5):1319-26.
Wong Tin Wui, Heng Paul Wan Sia, Yeo T N, Chan Lai Wah
Influence of polyvinylpyrrolidone on aggregation propensity of coated spheroids.
International journal of pharmaceutics 2002; 242(1-2):357-60.
Wong Tin Wui, Chan Lai Wah, Kho Shyan Bin, Heng Paul Wan Sia
Design of controlled-release solid dosage forms of alginate and chitosan using microwave.
Journal of controlled release 2002; 84(3):99-114.
Wong Tin Wui, Lee Huey Ying, Chan Lai Wah, Heng Paul Wan Sia
Drug release properties of pectinate microspheres prepared by emulsification method.
International journal of pharmaceutics 2002; 242(1-2):233-7.
Liew Celine Valeria, Gu Li, Heng Paul Wan Sia
The influence of operational variables on mean size and size distribution of spheroids produced by rotary spheronization using teardrop studs.
International journal of pharmaceutics 2002; 242(1-2):345-8.
Heng Paul Wan Sia, Easterbrook Michael G
Tablet coating technology.
European pharmaceutical review 2002; 7(3):44-47.
Chan Lai Wah, Lee Huey Ying, Heng Paul Wan Sia
Production of alginate microspheres by internal gelation using an emulsification method.
International journal of pharmaceutics 2002; 242(1-2):259-62.
Chan Lai Wah, Jin Y, Heng Paul Wan Sia
Cross-linking mechanisms of calcium and zinc in production of alginate microspheres.
International journal of pharmaceutics 2002; 242(1-2):255-8.
2001
Koo Otilia May Yue, Heng Paul Wan Sia
The influence of microcrystalline cellulose grade on shape and shape distributions of pellets produced by extrusion-spheronization.
Chemical & pharmaceutical bulletin 2001; 49(11):1383-7.
Heng Paul Wan Sia, Chan Lai Wah, Easterbrook Michael G, Li XiaoMan
Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets.
Journal of controlled release 2001; 76(1-2):39-49.
Heng Paul Wan Sia, Koo Otilia May Yue
A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronization.
Pharmaceutical research 2001; 18(4):480-7.
Chan Lai Wah, Chan Wai Yee, Heng Paul Wan Sia
An improved method for the measurement of colour uniformity in pellet coating.
International journal of pharmaceutics 2001; 213(1-2):63-74.
2000
Wong Tin Wui, Chan Lai Wah, Heng Paul Wan Sia
Study of the melt pelletization process focusing on the micromeritic property of pellets.
Chemical & pharmaceutical bulletin 2000; 48(11):1639-43.
Chan Lai Wah, Lim Liang Theng, Heng Paul Wan Sia
Microencapsulation of oils using sodium alginate.
Journal of microencapsulation 2000; 17(6):757-66.
Heng Paul Wan Sia, Chan Lai Wah, Liew Celine Valeria, Ng Teng Yong
Effect of tabletting compaction pressure on alginate microspheres.
Journal of microencapsulation 2000; 17(5):553-64.
Liew Celine Valeria, Wan Lucy Sai Cheong, Heng Paul Wan Sia
Role of base plate rotational speed in controlling spheroid size distribution and minimizing oversize particle formation during spheroid production by rotary processing.
Drug development and industrial pharmacy 2000; 26(9):953-63.
Heng Paul Wan Sia, Wong Tin Wui, Chan Lai Wah
Influence of production variables on the sphericity of melt pellets.
Chemical & pharmaceutical bulletin 2000; 48(3):420-4.
Heng Paul Wan Sia, Chan Lai Wah, Lim Liang Theng
Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate.
Chemical & pharmaceutical bulletin 2000; 48(3):393-8.
Sim K M, Boey S K, Heng Paul Wan Sia, Chan Y W
Total intravenous anaesthesia using 3-in-1 mixture of propofol, alfentanil and mivacurium.
Annals of the academy of medicine, Singapore 2000; 29(2):182-8.
Heng Paul Wan Sia, Chan Lai Wah, Zhu Li
Effects of process variables and their interactions of melt pelletization in high shear mixer.
Sciences techniques pharmaceutische pharma sciences 2000; 10(2):165-172.
Heng Paul Wan Sia, Chan Lai Wah, Lee Chin Chiat
Ultrafine grinding using a fluidised bed opposed jet mill: effects of process parameters on the size distribution of milled particles.
Sciences techniques pharmaceutische pharma sciences 2000; 10(1):445-451.
Chan Lai Wah, Kurup T R Ramachandra, Muthaiah A, Thenmozhiyal Jeyanthi Chinnappa
Interaction of p-hydroxybenzoic esters with beta-cyclodextrin.
International journal of pharmaceutics 2000; 195(1-2):71-9.
1999
Heng Paul Wan Sia, Wong Tin Wui, Shu Jian Jun, Wan Lucy Sai Cheong
A new method for the control of size of pellets in melt pelletization process with a high shear mixer.
Chemical & pharmaceutical bulletin 1999; 47(5):633-38.
Heng Paul Wan Sia, Chan Lai Wah, Chan Wai Yee
Application of spot colour measurement for the optimisation of color coating.
Sciences techniques pharmaceutische pharma sciences 1999; 9(6):539-544.
Chan Lai Wah, Hao Jin Song, Heng Paul Wan Sia
Evaluation on permeability and mechanical property of composite polyvinyl alcohol films.
Chemical & pharmaceutical bulletin 1999; 47(10):1412-16.
Heng Paul Wan Sia; Wong Tin Wui; Wan Lucy Sai Cheong
A probe test method for determination of molten binder tack.
Pharmaceutical development and technology 1999; 4(3):457-60.
Wong Tin Wui, Wan Lucy Sai Cheong, Heng Paul Wan Sia
Effects of physical properties of PEG 6000 on pellets produced by melt pelletization.
Pharmaceutical development and technology 1999; 4(3):449-56.
Heng Paul Wan Sia, Chan Lai Wah, Chew Siok Hui
Mechanism of pellet coat rupture and its effect on drug release.
Chemical & pharmaceutical bulletin 1999; 47(7):939-43.
Heng Paul Wan Sia, Wan Lucy Sai Cheong, Wong Tin Wui
Effect of off-bottom clearance on properties of pellets produced by melt pelletization.
Pharmaceutical development and technology 1999; 4(1):27-33.
Tan Yvonne Tze Fung, Heng Paul Wan Sia, Wan Lucy Sai Cheong
Mixed polymer coating for modified release from coated spheroids.
Pharmaceutical development and technology 1999; 4(4):561-70.
1998
Chan Lai Wah, Heng Paul Wan Sia
Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification.
Journal of microencapsulation 1998; 15(4):409-20.
Wan Lucy Sai Cheong, Tan Yvonne Tze Fung, Heng Paul Wan Sia
Drug release kinetics of bi-layer coated spheroids.
Sciences techniques pharmaceutische pharma sciences 1998; 8(2):113-122.
Tan Yvonne Tze Fung, Wan Lucy Sai Cheong, Heng Paul Wan Sia
Evaluation of adhesion strength measurement for predicting aggregation propensity during fluidised bed coating.
Sciences techniques pharmaceutische pharma sciences 1998; 8(3):149-153.
Liew Celine Valeria, Wan Lucy Sai Cheong, Heng Paul Wan Sia
Influence of polytetrafluoroethylene on spheroid production by rotary processing.
Sciences techniques pharmaceutische pharma sciences 1998; 8(5):297-302.
1997
Heng Paul Wan Sia, Chan Lai Wah
Drug substance and excipient characterization.
In: Parikh D M (Ed). Handbook of pharmaceutical granulation technology, 1st ed. Florida: Taylor & Francis.
Chan Lai Wah, Heng Paul Wan Sia, Wan Lucy Sai Cheong
Effect of cellulose derivatives on alginate microspheres prepared by emulsification.
Journal of microencapsulation 1997; 14(5):545-55.
Wan Lucy Sai Cheong, Heng Paul Wan Sia, Chan Lai Wah, Lee Chin Chiat, Ho E K, Ngoh W K, Lam T J, Waldord J J
Effect of feeding microspheres containing thyroid hormone on larval growth and development on tilapia and seabass.
Journal of aquaculture in the tropics 1997; 12:191-9.