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Research Focus

  1. Metabolism-driven systems biology modeling of diseases, pharmacology, toxicology and mammalian host-bacteria interactions.
  2. Xenobiotic-derived reactive metabolite research with specific focus on interaction with biological proteins, regulation of metabolic pathway, protein post-translational modification and physiological-based pharmacokinetics-pharmacodynamics (PBPK-PD) modeling of pharmacology and toxicology.
  •  Principal Investigator

  •  Invited Lecture

    • 1st Conference of the Indian Society for the Study of Xenobiotics (SSX®), 1-3 September 2016, Bangalore, India.
    • KSCPT Spring Conference, 14 June 2016, Busan, Korea
    • 11th International Meeting of the International Society for the Study of Xenobiotics (ISSX), 12-16 June 2016, Busan, Korea.
    • Department of Biochemistry Seminar, 9 Novemeber 2015,  National University of Singapore, Singapore
    • 13th European Meeting of the International Society for the Study of Xenobiotics (ISSX), 22-25 June 2015, Glasgow, Scotland.
    • Annual Pharmacy Research Awareness Symposium, 8-9 April 2015, National University of Singapore, Singapore
    • NUS-Kanagawa Urology Symposium, 19 January 2015, National University of Singapore, Singapore.
    • Asia Pacific International Society for the Study of Xenobiotics (AP-ISSX) Meeting, 9-12 May 2014, Tianjin, China.
    • 2nd Singapore Society for Biochemistry and Molecular Biology (SSBMB) Focused Meeting on Cancer and Metabolism, 8 January 2013, National University of Singapore, Singapore.
    • Special Seminar by Visiting Professor, 13 December 2012, School of Pharmacy, University of Washington, USA.
    • 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, 25-26 May 2011, Universiti Putra, Malaysia
    • Conference on Advanced Chemical and Membrane Technology – Growth Opportunities in Life Science & Pharmaceuticals, Water Reuse & Desalination and Energy Applications, 13-14 April 2010, National University of Singapore, Singapore.
    • Distinguish Speaker, 20th International Colorectal Scientific Congress, 17 November 2009, Pan Pacific Singapore, Singapore.
    • Separation Science Singapore, 26-28 August 2009, Biopolis Science Park, Singapore.
  • Research Staff

  • Postgraduate Students

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    Alumni

  • Yanjun HONG

    (PhD)
    Research Assistant Professor
    State Key Lab. of Environ. &  Bio. Anal.
    Department of Chemistry
    Hong Kong Baptist University, China

  • Gopalakrishnan VENKATESAN

    (PhD)
    Research Fellow
    Department of Pharmacy, Pastorin Giorgia’s Lab
    National University of Singapore, Singapore

  • Liyan CHEN

    (PhD)
    Research Fellow
    Paer Nordlund Lab
    School of Biological Science,
    Nanyang Technological University

  • Lee Cheng PHUA

    (PhD, BSc Pharmacy Hons)
    Specialist (Oncology Drugs)
    Agency for Care Effectiveness
    Ministry of Health, Singapore

  • Lian Yee YIP

    (PhD, BSc Pharmacy Hons)
    Research Scientist
    A*STAR Bioprocessing Technology Institute, Singapore

  • Theebarina GOPALAKRISHNAN

    (BSc Chemistry)
    Senior Research Officer
    Natural Product Research Laboratory,
    A*STAR Bioinformatics Institute, Singapore

  • Prity Baldeodas BAHETY

    (PhD)
    Future Leader Program (R&D) Associate
    GlaxoSmithKline, Belgium

  • Mainak MAL

    (PhD)
    Executive, Quality Control
    Fresenius Kabi Oncology Ltd, India

  • Thiru Selvi D/O SELVARAJAH

    (MSc)
    Analyst
    Turf Club Laboratory, Singapore

  • Kishore Kumar PASIKANTI

    (PhD)
    Investigator DMPK, GSK Associate Fellow
    RD II DPU3 Ptrn RR DMPK Group,
    R&D ImmunoInflammation,
    GlaxoSmithKline, USA

  • Xiang MA

    (PhD)
    Associate Professor
    School of Pharmacy
    Huazhong University of Science & Technology, China

  • Hui Ting CHNG

    (PhD, BSc Pharmacy Hons)
    Instructor
    Department of Pharmacy,
    National University of Singapore, Singapore

  • Zeping HU

    (PhD)
    Assistant Professor
    Department of Pharmaceutical Chemistry and Engineering
    School of Pharmaceutical Science,
    Tsinghua University, China

  • Ronald Fook Seng LEE

    (BSc Pharmacy Hons)
    PhD Candidate, Ecole Polytechnique Federale de Lausanne, Swtizerland

  • Saha SUDIPTA

    (PhD)
    Assistant Professor
    Department of Pharmaceutical Sciences
    Babasaheb Bhimrao Ambedkar University, India

  • Chiu Cheong AW

    (Msc)
    Application Scientist
    AB SCIEX Manufacturing,
    AB SCIEX Pte Ltd, Singapore

  • Kai Lun CHANG

    (PhD)
    Entrepreneur
    3D Printing, UK

  • Lee Sun NEW

    (MSc)
    Application Chemist
    AB SCIEX Manufacturing,
    AB SCIEX Pte Ltd, Singapore

  • Yee Min TAN

    (BSc Chemistry Hons)
    Marketing Executive
    John Wiley & Sons (Singapore) Pte Ltd, Singapore

  • Current & Graduated Final Year Project Students

  • FYP 16/17

    Shi Zong Nigel LIM
    Rou Hui HO
    Jia Yun WOON
    Jun Jie TAN
    Dai Thien Nhan TRAM

  • FYP 15/16

    Jia Le LIM
    Jacqueline Wen Hui LEOW
    Janice Jia Ni GOH
    Shuxu GOH
    Wei Shan TAN

  • FYP 14/15

    Eleanor Jing Yi CHEONG
    Hui Yuan LAM
    Kwok Foong LAM
    Wan Jing NG
    Hwee Ying TAY
    Preben Xiang Long TENG

  • FYP 13/14

    Ray Hng YEO
    Ler Min Tasmin TEO
    Thi Hai Van NGUYEN
    Peirong LIM
    Sze Han LEE
    Yi Shuen HONG
    Yin Bing Winnie FOO
    Devester Yun Ming CHOO
    Rui Wen Davis CHONG

  • FYP 12/13

    Jessalyn Mei Xuan CHAN
    Yvonne Mei Fen CHIA
    Peiyi CHUAH
    Han Chen KU
    Si Zheng KWONG
    Winston Hecheng XU

  • FYP 11/12

    Hui Wen NG
    Weilong YEO

  • FYP 10/11

    Joaane Hui Yu LAU
    Teck Beng CHUA
    Debra Shu Zhen CHAN
    James Chun Yip CHAN
    Javin Xu Hong TANG

  • FYP 09/10

    Shu Hui THNG
    Cecilia Woon Chien TENG
    Doreen Jia Yi NG
    Chern Yih LEE
    Yueting KOH
    Pik Wei GOH
    Kai Lun CHANG

  • FYP 08/09

    Lian Yee YIP
    Tiong Phew TEW
    Jing Wen OH
    Dilys Pei Qi GOH

  • FYP 07/08

    Su Ching TAN
    Li Ting TAN
    Lee Cheng PHUA
    Hui Ting CHNG

  • FYP 06/07

    Jye CHyi LEE
    Kai Xin ONG

Pedagogical Goal

To nurture active, creative and reflective lifelong learners in pharmacokinetics and xenobiotic metabolism so as to develop competent future-ready pharmacists and pharmaceutical scientists for the clinical and pharmaceutical industries.

 

Module

PR3106 Pharmacokinetics & Drug Disposition

PR5222 Drug Metabolism

 

Scholarship in Teaching and Learning

  1. KL Ng, X Deng, S Zhang, MYZ Chng, TC Chua, LL Koh, XJ Sim, V Aryadoust and ECY Chan*. Effectiveness of New Science Communication Course – A Preliminary Report. Asian Journal of the Scholarship of Teaching and Learning (AJSoTL) 4(4) (December 2014) 196-205.
  2. ECY Chan* and ER Browne. Incorporating an Educational Field Trip into the Teaching of Pharmaceutical R&D for Pharmacy Students: A Case Study. Pharmacy Education 11(1) (October 2011) 91-94.
  3. ECY Chan* and HK Ho*. Investigation of online computer-based formative assessment (CBFA) and traditional closed-book paper-based assessment in pharmacy undergraduate teaching. Technology in Higher Education: The State of the Art (2011) 152-163.
  4. ECY Chan*. Reflections on Teaching. CDTLink Newsletter 13(2) (2009).
  5. ECY Chan*. Processes in Module Planning. CDTL Brief 12(3) (2009).
  6. ECY Chan* and ER Browne. Incorporating an Educational Field Trip to Enhance Pharmacy Students’ Knowledge of Pharmaceutical R&D.CDTLink Newsletter 12(2) (2008).
  7. ECY Chan*. Enhancing pharmaceutical analysis laboratory classes via the measurement of minerals in Berocca® effervescent tablets. Pharmacy Education 8(1) (2008) 53-57.
  8. ECY Chan*. Enhancing Pharmaceutical Analysis Laboratory Classes. CDTLink Newsletter 11(2) (2007).

Key Publications

  1. A Karkhanis, HY Lam, G Venkatesan, SK Koh, CLL Chai, L Zhou, Y Hong, P Kojodjojo and ECY Chan*. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Biochemical Pharmacology 107 (May 2016) 67-80.
  2. LY Chen, CY Cheng, H Choi, MK Ikram, C Sabanayagam, GSW Tan, D Tian, L Zhang, G Venkatesan, ES Tai, JJ Wang, P Mitchell, CMG Cheung, RW Beuerman, L Zhou*, ECY Chan* and TY Wong*. Plasma Metabonomic Profiling of Diabetic Retinopathy. Diabetes 65 (April2016) 1099 -1108.
  3. Y Hong, YMF Chia, RH Yeo, G Venkatesan, SK Koh, CLL Chai, L Zhou, P Kojodjojo and ECY Chan*. Inactivation of human cytochrome P450 3A4 and 3A5 by dronedarone and N-desbutyl dronedarone. Molecular Pharmacology 89 (January 2016) 1-13.
  4. LY Yip and ECY Chan*. Investigation of Host-Gut Microbiota Modulation of Therapeutic Outcome. Drug Metabolism and Disposition 43 (October 2015) 1619-1631.
  5. EA Bard-Chapeau, A Nguyen, AG Rust, A Sayadi, P Lee, BQ Chua, LS New, J de Jong, JM Ward, CKY Chin, V Chew, HC Toh, J Abastado, T Benoukraf , R Soong, FA Bard, AJ Dupuy, RL Johnson, GK Radda, ECY Chan, LFA Wessels, DJ Adams, NA Jenkins and NG Copeland*. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (January 2014) 24-32.
  6. KK Pasikanti, K Esuvaranathan,Y Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and ECY Chan*. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 12 (September 2013) 3865-3873.
  7. ECY Chan*, LS New, TB Chua, CW Yap, HK Ho and SD Nelson. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism & Disposition 40 (July 2012) 1414-1422.
  8. ECY Chan*, KK Pasikanti and JK Nicholson. Global urinary metabolic profiling procedures using gas chromatography mass spectrometry. Nature Protocols 6 (October 2011) 1483-1499.
  9. KK Pasikanti, K Esuvaranathan, PC Ho, R Mahendran, R Kamaraj, QH Wu, E Chiong and ECY Chan*. Noninvasive urinary metabonomic diagnosis of human bladder cancer. Journal of Proteome Research 9 (2010) 2988-2995.
  10. WC Teng, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho and ECY Chan*. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology 78 (2010) 693-703.
  11. ECY Chan*, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, JK Nicholson and H Keun. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research 8 (2009) 351-361.

Thank you for your interest in joining MPRG. We regret to inform you that the below-mentioned position has been filled.

 

Research Fellow (1 year contract, effective from 15 October 2015)

We are looking for a highly motivated research fellow to work on targeted and global metabonomics research.

Requirements: 

  • PhD in Pharmacy, Chemistry or Biology (or equivalent)
  • Experience in liquid and gas chromatography mass spectrometry techniques
  • Experience in clinical metabonomics and biomarker research will be considered favorable
  • Be proficient in English, with good interpersonal skill and team player.

Responsibilities includes:

  • Perform metabonomics experiments independently
  • Supervise undergraduate research project such as final year projects

Salary and benefits will commensurable with qualifications and working experience. Please address your full application including a cover letter describing your research experiences, a full CV, list of publications (if available) and 2 references to:

Associate Professor Eric Chan (eric.chan@nus.edu.sg)

Kindly email us via the “People” tab.

Address: 6 Science Drive 3 Singapore 117554, Science Blk 7 Level 2