- Metabolism-driven systems biology modeling of diseases, pharmacology, toxicology and mammalian host-bacteria interactions.
- Xenobiotic-derived reactive metabolite research with specific focus on interaction with biological proteins, regulation of metabolic pathway, protein post-translational modification and physiological-based pharmacokinetics-pharmacodynamics (PBPK-PD) modeling of pharmacology and toxicology.
To nurture active, creative and reflective lifelong learners in pharmacokinetics and xenobiotic metabolism so as to develop competent future-ready pharmacists and pharmaceutical scientists for the clinical and pharmaceutical industries.
PR3106 Pharmacokinetics & Drug Disposition
PR5222 Drug Metabolism
Scholarship in Teaching and Learning
- KL Ng, X Deng, S Zhang, MYZ Chng, TC Chua, LL Koh, XJ Sim, V Aryadoust and ECY Chan*. Effectiveness of New Science Communication Course – A Preliminary Report. Asian Journal of the Scholarship of Teaching and Learning (AJSoTL) 4(4) (December 2014) 196-205.
- ECY Chan* and ER Browne. Incorporating an Educational Field Trip into the Teaching of Pharmaceutical R&D for Pharmacy Students: A Case Study. Pharmacy Education 11(1) (October 2011) 91-94.
- ECY Chan* and HK Ho*. Investigation of online computer-based formative assessment (CBFA) and traditional closed-book paper-based assessment in pharmacy undergraduate teaching. Technology in Higher Education: The State of the Art (2011) 152-163.
- ECY Chan*. Reflections on Teaching. CDTLink Newsletter 13(2) (2009).
- ECY Chan*. Processes in Module Planning. CDTL Brief 12(3) (2009).
- ECY Chan* and ER Browne. Incorporating an Educational Field Trip to Enhance Pharmacy Students’ Knowledge of Pharmaceutical R&D.CDTLink Newsletter 12(2) (2008).
- ECY Chan*. Enhancing pharmaceutical analysis laboratory classes via the measurement of minerals in Berocca® effervescent tablets. Pharmacy Education 8(1) (2008) 53-57.
- ECY Chan*. Enhancing Pharmaceutical Analysis Laboratory Classes. CDTLink Newsletter 11(2) (2007).
- ECY Chan*, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, JK Nicholson and H Keun. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research 8 (2009) 351-361. As of November/December 2016, this highly cited paper received enough citations to place it in the top 1% of the academic field of Biology & Biochemistry based on a highly cited threshold for the field and publication year.
- WC Teng, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho and ECY Chan*. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology 78 (2010) 693-703.
- KK Pasikanti, K Esuvaranathan, PC Ho, R Mahendran, R Kamaraj, QH Wu, E Chiong and ECY Chan*. Noninvasive urinary metabonomic diagnosis of human bladder cancer. Journal of Proteome Research 9 (2010) 2988-2995.
- ECY Chan*, KK Pasikanti and JK Nicholson. Global urinary metabolic profiling procedures using gas chromatography mass spectrometry. Nature Protocols 6 (October 2011) 1483-1499.
- ECY Chan*, LS New, TB Chua, CW Yap, HK Ho and SD Nelson. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism & Disposition 40 (July 2012) 1414-1422.
- KK Pasikanti, K Esuvaranathan,Y Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and ECY Chan*. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 12 (September 2013) 3865-3873.
- EA Bard-Chapeau, A Nguyen, AG Rust, A Sayadi, P Lee, BQ Chua, LS New, J de Jong, JM Ward, CKY Chin, V Chew, HC Toh, J Abastado, T Benoukraf , R Soong, FA Bard, AJ Dupuy, RL Johnson, GK Radda, ECY Chan, LFA Wessels, DJ Adams, NA Jenkins and NG Copeland*. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (January 2014) 24-32.
- LY Yip and ECY Chan*. Investigation of Host-Gut Microbiota Modulation of Therapeutic Outcome. Drug Metabolism and Disposition 43 (October 2015) 1619-1631.
- Y Hong, YMF Chia, RH Yeo, G Venkatesan, SK Koh, CLL Chai, L Zhou, P Kojodjojo and ECY Chan*. Inactivation of human cytochrome P450 3A4 and 3A5 by dronedarone and N-desbutyl dronedarone. Molecular Pharmacology 89 (January 2016) 1-13.
- LY Chen, CY Cheng, H Choi, MK Ikram, C Sabanayagam, GSW Tan, D Tian, L Zhang, G Venkatesan, ES Tai, JJ Wang, P Mitchell, CMG Cheung, RW Beuerman, L Zhou*, ECY Chan* and TY Wong*. Plasma Metabonomic Profiling of Diabetic Retinopathy. Diabetes 65 (April 2016) 1099 -1108.
- A Karkhanis, HY Lam, G Venkatesan, SK Koh, CLL Chai, L Zhou, Y Hong, P Kojodjojo and ECY Chan*. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Biochemical Pharmacology 107 (May 2016) 67-80.
Clinical Trial Officer in the Department of Urology/Surgery, Yong Loo Lin School of Medical.
Department of Urology, Surgery, is reputed for conducting multi-disciplinary research in many areas including translational research. In this research project, the PI is collaborating with the Department of Pharmacy, NUS. Appointment will be made on a one-year contract, with the possibility of extension.
The Clinical Trial Officer (CTO) will be responsible to, and work closely with, the Principal Investigator and study team members to ensure the successful completion of the trial on time. The CTO’s principal role will be to work in Clinical Research conducted according to SGGCP guidelines.
Main duties and responsibilities
The Clinical Trial Officer will liaise with the relevant personnel in NUH, NUS and other institutions and will be accountable to the Principle Investigator (PI).
The CTO will be able to:
- Oversee the general management of the project;
- Provide administrative and secretarial support to the project, such as organizing regular meetings to maintain regular communication with other members of the research team;
- Undertake the day to day running of the project at the study site, e.g. screening and recruiting patients, documentation of processes related to the projects, data collection and documentation, submitting reports to regulatory authorities and sponsor
- Maintain the highest standard of professional conduct and record keeping in accordance with SGGCP guidelines;
- Assist with any other duties of a similar nature that are delegated by the PI.
The applicant should:
- Have a basic degree in biochemistry/life sciences or related disciplines or nursing degree; preferably with some experience in clinical research;
- Be able to work independently and in a team, have an investigative nature, attention to detail; and
- Have knowledge of computer applications, e.g. SPSS, MS office, PowerPoint.
Remuneration will be commensurate with the candidate’s qualifications and experience. Informal enquiries are welcome and should be made to Dr Lata Raman, at 67725643.
Formal application: Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of three referees to: