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Research Focus

  1. Metabolism-driven systems biology modeling of diseases, pharmacology, toxicology and mammalian host-bacteria interactions.
  2. Xenobiotic-derived reactive metabolite research with specific focus on interaction with biological proteins, regulation of metabolic pathway, protein post-translational modification and physiological-based pharmacokinetics-pharmacodynamics (PBPK-PD) modeling of pharmacology and toxicology.
  •  Principal Investigator

  •  Invited Lecture

    • School of Pharmacy Research Seminar, 3-4 August 2017, University of Maryland, Baltimore, United States of America.
    • 1st Conference of the Indian Society for the Study of Xenobiotics (SSX®), 1-3 September 2016, Bangalore, India.
    • KSCPT Spring Conference, 14 June 2016, Busan, Korea
    • 11th International Meeting of the International Society for the Study of Xenobiotics (ISSX), 12-16 June 2016, Busan, Korea.
    • Department of Biochemistry Seminar, 9 Novemeber 2015,  National University of Singapore, Singapore
    • 13th European Meeting of the International Society for the Study of Xenobiotics (ISSX), 22-25 June 2015, Glasgow, Scotland.
    • Annual Pharmacy Research Awareness Symposium, 8-9 April 2015, National University of Singapore, Singapore
    • NUS-Kanagawa Urology Symposium, 19 January 2015, National University of Singapore, Singapore.
    • Asia Pacific International Society for the Study of Xenobiotics (AP-ISSX) Meeting, 9-12 May 2014, Tianjin, China.
    • 2nd Singapore Society for Biochemistry and Molecular Biology (SSBMB) Focused Meeting on Cancer and Metabolism, 8 January 2013, National University of Singapore, Singapore.
    • Special Seminar by Visiting Professor, 13 December 2012, School of Pharmacy, University of Washington, USA.
    • 25th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, 25-26 May 2011, Universiti Putra, Malaysia
    • Conference on Advanced Chemical and Membrane Technology – Growth Opportunities in Life Science & Pharmaceuticals, Water Reuse & Desalination and Energy Applications, 13-14 April 2010, National University of Singapore, Singapore.
    • Distinguish Speaker, 20th International Colorectal Scientific Congress, 17 November 2009, Pan Pacific Singapore, Singapore.
    • Separation Science Singapore, 26-28 August 2009, Biopolis Science Park, Singapore.
  • Research Staff

  • Postgraduate Students

  • icon

    Alumni

  • Yanjun HONG

    (PhD)
    Research Assistant Professor
    State Key Lab. of Environ. &  Bio. Anal.
    Department of Chemistry
    Hong Kong Baptist University, China

  • Gopalakrishnan VENKATESAN

    (PhD)
    Research Fellow
    Department of Pharmacy, Pastorin Giorgia’s Lab
    National University of Singapore, Singapore

  • Liyan CHEN

    (PhD)
    Research Fellow
    Paer Nordlund Lab
    School of Biological Science,
    Nanyang Technological University

  • Lee Cheng PHUA

    (PhD, BSc Pharmacy Hons)
    Specialist (Oncology Drugs)
    Agency for Care Effectiveness
    Ministry of Health, Singapore

  • Lian Yee YIP

    (PhD, BSc Pharmacy Hons)
    Research Scientist
    A*STAR Bioprocessing Technology Institute, Singapore

  • Theebarina GOPALAKRISHNAN

    (BSc Chemistry)
    Senior Research Officer
    Natural Product Research Laboratory,
    A*STAR Bioinformatics Institute, Singapore

  • Prity Baldeodas BAHETY

    (PhD)
    Future Leader Program (R&D) Associate
    GlaxoSmithKline, Belgium

  • Mainak MAL

    (PhD)
    Executive, Quality Control
    Fresenius Kabi Oncology Ltd, India

  • Thiru Selvi D/O SELVARAJAH

    (MSc)
    Analyst
    Turf Club Laboratory, Singapore

  • Kishore Kumar PASIKANTI

    (PhD)
    Investigator DMPK, GSK Associate Fellow
    RD II DPU3 Ptrn RR DMPK Group,
    R&D ImmunoInflammation,
    GlaxoSmithKline, USA

  • Xiang MA

    (PhD)
    Associate Professor
    School of Pharmacy
    Huazhong University of Science & Technology, China

  • Hui Ting CHNG

    (PhD, BSc Pharmacy Hons)
    Instructor
    Department of Pharmacy,
    National University of Singapore, Singapore

  • Zeping HU

    (PhD)
    Assistant Professor
    Department of Pharmaceutical Chemistry and Engineering
    School of Pharmaceutical Science,
    Tsinghua University, China

  • Ronald Fook Seng LEE

    (BSc Pharmacy Hons)
    PhD Candidate, Ecole Polytechnique Federale de Lausanne, Swtizerland

  • Saha SUDIPTA

    (PhD)
    Assistant Professor
    Department of Pharmaceutical Sciences
    Babasaheb Bhimrao Ambedkar University, India

  • Chiu Cheong AW

    (Msc)
    Application Scientist
    AB SCIEX Manufacturing,
    AB SCIEX Pte Ltd, Singapore

  • Kai Lun CHANG

    (PhD)
    Entrepreneur
    3D Printing, UK

  • Lee Sun NEW

    (MSc)
    Application Chemist
    AB SCIEX Manufacturing,
    AB SCIEX Pte Ltd, Singapore

  • Yee Min TAN

    (BSc Chemistry Hons)
    Marketing Executive
    John Wiley & Sons (Singapore) Pte Ltd, Singapore

  • Current & Graduated Final Year Project Students

  • FYP 17/18

    Jing MIAO
    Rachelle Wei-Ting LOW
    Ervin Zhi Bin CHEONG
    Rebecca Wan Yi NEO

  • FYP 16/17

    Shi Zong Nigel LIM
    Rou Hui HO
    Jia Yun WOON
    Jun Jie TAN
    Dai Thien Nhan TRAM

  • FYP 15/16

    Jia Le LIM
    Jacqueline Wen Hui LEOW
    Janice Jia Ni GOH
    Shuxu GOH
    Wei Shan TAN

  • FYP 14/15

    Eleanor Jing Yi CHEONG
    Hui Yuan LAM
    Kwok Foong LAM
    Wan Jing NG
    Hwee Ying TAY
    Preben Xiang Long TENG

  • FYP 13/14

    Ray Hng YEO
    Ler Min Tasmin TEO
    Thi Hai Van NGUYEN
    Peirong LIM
    Sze Han LEE
    Yi Shuen HONG
    Yin Bing Winnie FOO
    Devester Yun Ming CHOO
    Rui Wen Davis CHONG

  • FYP 12/13

    Jessalyn Mei Xuan CHAN
    Yvonne Mei Fen CHIA
    Peiyi CHUAH
    Han Chen KU
    Si Zheng KWONG
    Winston Hecheng XU

  • FYP 11/12

    Hui Wen NG
    Weilong YEO

  • FYP 10/11

    Joaane Hui Yu LAU
    Teck Beng CHUA
    Debra Shu Zhen CHAN
    James Chun Yip CHAN
    Javin Xu Hong TANG

  • FYP 09/10

    Shu Hui THNG
    Cecilia Woon Chien TENG
    Doreen Jia Yi NG
    Chern Yih LEE
    Yueting KOH
    Pik Wei GOH
    Kai Lun CHANG

  • FYP 08/09

    Lian Yee YIP
    Tiong Phew TEW
    Jing Wen OH
    Dilys Pei Qi GOH

  • FYP 07/08

    Su Ching TAN
    Li Ting TAN
    Lee Cheng PHUA
    Hui Ting CHNG

  • FYP 06/07

    Jye CHyi LEE
    Kai Xin ONG

Pedagogical Goal

To nurture active, creative and reflective lifelong learners in pharmacokinetics and xenobiotic metabolism so as to develop competent future-ready pharmacists and pharmaceutical scientists for the clinical and pharmaceutical industries.

 

Module

PR3106 Pharmacokinetics & Drug Disposition

PR5222 Drug Metabolism

 

Scholarship in Teaching and Learning

  1. KL Ng, X Deng, S Zhang, MYZ Chng, TC Chua, LL Koh, XJ Sim, V Aryadoust and ECY Chan*. Effectiveness of New Science Communication Course – A Preliminary Report. Asian Journal of the Scholarship of Teaching and Learning (AJSoTL) 4(4) (December 2014) 196-205.
  2. ECY Chan* and ER Browne. Incorporating an Educational Field Trip into the Teaching of Pharmaceutical R&D for Pharmacy Students: A Case Study. Pharmacy Education 11(1) (October 2011) 91-94.
  3. ECY Chan* and HK Ho*. Investigation of online computer-based formative assessment (CBFA) and traditional closed-book paper-based assessment in pharmacy undergraduate teaching. Technology in Higher Education: The State of the Art (2011) 152-163.
  4. ECY Chan*. Reflections on Teaching. CDTLink Newsletter 13(2) (2009).
  5. ECY Chan*. Processes in Module Planning. CDTL Brief 12(3) (2009).
  6. ECY Chan* and ER Browne. Incorporating an Educational Field Trip to Enhance Pharmacy Students’ Knowledge of Pharmaceutical R&D.CDTLink Newsletter 12(2) (2008).
  7. ECY Chan*. Enhancing pharmaceutical analysis laboratory classes via the measurement of minerals in Berocca® effervescent tablets. Pharmacy Education 8(1) (2008) 53-57.
  8. ECY Chan*. Enhancing Pharmaceutical Analysis Laboratory Classes. CDTLink Newsletter 11(2) (2007).

2017

  1. RH Ho, JCY Chan, F Hao, DYQ Kioh, BW Lee* and ECY Chan*. In silico and In vitro interactions between short chain fatty acids and human histone deacetylases. Biochemistry 56 (2017) 4871 – 4878 DOI: 10.1021/acs.biochem.7b00508 In Press NEW!
  2. LY Yip, CC Aw, SH Lee, YS Hong, HC Ku, WH Xu, JMX Chan, EJY Cheong, KR Chng, AHQ Ng, N Nagarajan, R Mahendran, YK Lee, ER Browne and ECY Chan*. The liver-gut microbiota axis modulates hepatotoxicity of tacrine of the rat. Hepatology (2017) DOI:10.1002/hep.29327 In Press NEW! Faculty of Science Research News
  3. JCY Chan, DYQ Kioh, GC Yap, BW Lee* and ECY Chan*. A novel LCMSMS method for quantitative measurement of short-chain fatty acids in human stool derivatized with 12C- and 13C-labelled aniline. Journal of Pharmaceutical and Biomedical Analysis 138 (May 2017) 43 – 53 DOI: 10.1016/j.jpba.2017.01.044
  4. Q Chen, C Li, Z Gong, ECY Chan, SA Snyder and SH Lam*. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-related high to low concentrations of glucocorticoids. Chermosphere. 172 (April 2017) 429 – 439 DOI: 10.1016/j.chemosphere.2017.01.036
  5. EJY Cheong, JJN Goh, Y Hong, G Venkatesan, Y Liu, GNC Chiu, P Kojodjojo and ECY Chan*. Application of static modeling in the prediction of in vivo drug-drug interactions between rivaroxaban and anti-arrhythmic agents based on in vitro inhibition studies. Drug Metabolism and Disposition 45 (March 2017) 260 – 268 DOI: 10.1124/dmd.116.073890
  6. P Bahety, THV Nguyen, Y Hong, L Zhang, ECY Chan* and PL Ee*.Understanding the cholesterol metabolism-perturbing effects of docosahexaenoic acid by gas chromatography-mass spectrometry targeted metabonomic profiling. European Journal of Nutrition 56 (February 2017) 29 – 43 DOI: 10.1007/s00394-015-1053-4
  7. JCY Chan, PS Ong, P Lim, PXL Teng and ECY Chan*. Synergistic disruption of ERα/HER2 crosstalk by endoxifen and lapatinib in breast cancer cells. Cancer Chemotherapy and Pharmacology 79 (January 2017) 117 – 130 DOI: 10.1007/s00280-016-3211-7
  8. YY Cai, TP Lim, J Teo, S Suranthran, ECY Chan, Y Hong, W Lee, TY Tan, TT Tan, TS Koh, LY Hsu and AL Kwa*. Evaluating polymyxin-B-based combinations against carbapenem-resistant Escherichia coli in time-kill studies and in a hollow-fiber infection model. Antimicrobial Agents and Chemotherapy 61 (January 2017) e01509 – e01516 DOI: 10.1128/AAC.01509-16 

2016

  1. YY Cai, TP Lim, J Teo, S Suranthran, W Lee, Y Hong, ECY Chan, TY Tan, TH Koh, HL Yang and AL Kwa*. In vitroActivity of Polymyxin B in combination with various antibiotics against extensively resistant Enterobacter cloacae with decreased susceptibility to Polymyxin B. Antimicrobial Agents and Chemotherapy 60 (September 2016) 5238 – 5246 DOI: 10.1128/AAC.00270-16
  2. YY Pang, YM Tan, ECY Chan and HK Ho*. Phase I metabolic stability and electrophilic reactivity of 2-phenylaminophenylacetic acid derived compounds. Chemical Research in Toxicology 29 (July 2016) 1118 – 1131 DOI: 10.1021/acs.chemrestox.6b00042
  3. A Karkhanis, HY Lam, G Venkatesan, SK Koh, CLL Chai, L Zhou, Y Hong, P Kojodjojo and ECY Chan*. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Biochemical Pharmacology 107 (May 2016) 67 – 80 DOI:10.1016/j.bcp.2016.03.005 Faculty of Science Research News
  4. LY Chen, CY Cheng, H Choi, MK Ikram, C Sabanayagam, GSW Tan, D Tian, L Zhang, G Venkatesan, ES Tai, JJ Wang, P Mitchell, CMG Cheung, RW Beuerman, L Zhou*, ECY Chan* and TY Wong. Plasma Metabonomic Profiling of Diabetic Retinopathy. Diabetes 65 (April 2016) 1099 – 1108 DOI: 10.2337/db15-0661 Faculty of Science Research News
  5. C Li, P Li, YM Tan, SH Lam, ECY Chan and Z Gong*. Metabolomic characterization of liver injury caused by acute arsenic toxicity in zebrafish. PLOS ONE (March 2016) DOI: 10.137/journal.pone.0151225
  6. Y Hong, YMF Chia, RH Yeo, G Venkatesan, SK Koh, CLL Chai, L Zhou, P Kojodjojo and ECY Chan*. Inactivation of human cytochrome P450 3A4 and 3A5 by dronedarone and N-desbutyl dronedarone. Molecular Pharmacology 89 (January 2016) 1 – 13 DOI: 10.1124/mol.115.100891

2015

  1. JCY Chan, L Zhou and ECY Chan*. The Isotope-Coded Affinity Tag Method for Quantitative Protein Profile Comparison and Relative Quantitation of Cysteine Redox Modification. Current Protocols in Protein Science 82 (November 2015) 23.2.1 – 23.2.19 DOI: 10.1002/0471140864.ps2302s82
  2. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian and ECY Chan*. Gastrointestinal symptoms and altered intestinal permeability induced by combat-training are associated with distinct metabotypic changes. Journal of Proteome Research 14 (October 2015) 4734 – 4742 DOI: 10.1021/acs.jproteome.5b00603
  3. LY Yip and ECY Chan*. Investigation of Host-Gut Microbiota Modulation of Therapeutic Outcome. Drug Metabolism and Disposition 43 (October 2015) 1619 – 1631 DOI: 10.1124/dmd.115.063750
  4. WYB Foo, HY Tay, ECY Chan and AJ Lau*. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochemical Pharmacology 97 (October 2015) 320 – 330. DOI:10.1016/j.bcp.2015.07.036
  5. LC Phua, HW Ng, AHL Yeo, E Chen, MSM Lo, PY Cheah, ECY Chan, PK Koh* and HK Ho*. Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian metastatic colorectal cancer patients. Oncology Letters 10 (October 2015) 2519 – 2526. DOI: 10.3892/ol.2015.3560
  6. LY Chen, J Li, T Guo, S Ghosh, SK Koh, D Tian, L Zhang, D Jia, RW Beuerman, R Aebersold, ECY Chan*, L Zhou*. Global metabonomic and proteomic analysis of human conjunctival epithelial cells (IOBA-NHC) in response to hyperosmotic stress. Journal of Proteome Research 14 (August 2015) 3982 – 3995. DOI: 10.1021/acs.jproteome.5b00443
  7. TP Lim, YY Cai, Y Hong, ECY Chan, S Suranthran, J Teo, W Lee, TY Tan, LY Hsu, TH Koh, TT Tan and AL Kwa*. In-vitro Pharmacodynamics of Various Antibiotics in Combination against Extensively Drug-Resistant Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 59 (May 2015) 2515 – 2524.
  8. ECY Chan*, KK Pasikanti, Y Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and K Esuvaranathan*. Metabonomic profiling of bladder cancer. Journal of Proteome Research 14 (February 2015) 587 – 602.
  9. HK Ho, JCY Chan, KD Hardy and ECY Chan. Mechanism-based inactivation of CYP450 enzymes: a case study of lapatinib. Drug Metabolism Review 47 (February 2015) 21 – 28. Special Edition Dedicated to Sid Nelson’s Contributions to the Field of Drug Metabolism
  10. KL Chang, HN Pee, WP Tan, GS Dawe, E Holmes, JK Nicholson, ECY Chan and PC Ho*. Metabolic profiling of CHO-AßPP695 cells revealed mitochondrial dysfunction prior to Aß pathology and potential therapeutic effects of both PPARγ and PPARα agonisms for Alzheimer’s disease. Journal of Alzheimer’s Disease 44 (January 2015) 215 – 231.

2014

  1. LC Phua, XP Chue, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Global fecal microRNA profiling in the identification of biomarkers for colorectal cancer screening among Asians.Oncology Reports 32 (May 2014) 97 – 104
  2. LC Phua, XP Chue, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Non-invasive fecal metabonomic detection of colorectal cancer. Cancer Biology & Therapy 15 (April 2014) 389 – 397.
  3. MD Damavandi, ECY Chan, JP Kraus, PC Ho and TS Kang*. Development of an UPLC-MS/MS method for assaying the enzymatic activity of propionyl coenzyme-A carboxylase. Bioanalysis 6 (February 2014) 335 – 348.
  4. P Bahety, YM Tan, Y Hong, L Zhang, ECY Chan* and PL Ee*. Metabotyping of docosahexaenoic acid – treated Alzheimer’s disease cell model. PLOS ONE (February 2014) DOI: 10.1371/journal.pone.0090123.
  5. T Nema, ECY Chan, PC Ho*. Applications of monolithic materials for sample preparation.Journal of Pharmaceutical and Biomedical Analysis 87 (January 2014) 130 – 141.
  6. EA Bard-Chapeau, A Nguyen, AG Rust, A Sayadi, P Lee, BQ Chua, LS New, J de Jong, JM Ward, CKY Chin, V Chew, HC Toh, J Abastado, T Benoukraf , R Soong, FA Bard, AJ Dupuy, RL Johnson, GK Radda, ECY Chan, LFA Wessels, DJ Adams, NA Jenkins and NG Copeland*. Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model. Nature Genetics 46 (January 2014) 24 – 32.

2013

  1. LC Phua, PK Koh, PY Cheah, HK Ho* and ECY Chan*. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabonomic profiling of lyophilized human feces. Journal of Chromatography B 937 (October 2013) 103 – 113.
  2. KK Pasikanti, K Esuvaranathan,Y Hong, PC Ho, R Mahendran, LRN Mani, E Chiong and ECY Chan*. Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 12 (September 2013) 3865 – 3873.
  3. BD Prakash, K Esuvaranathan,PC Ho, KK Pasikanti, ECY Chan and CW Yap*. An automated Pearson’s correlation change classification (APC3) approach for GC/MS metabonomic data using total ion chromatogram (TIC). Analyst 138 (May 2013) 2883 – 2889.
  4. HH Cheong, J Masilamani, ECY Chan, SY Chan* and TT Phan*. Metabolically functional hepatocyte-like cells from human umbilical cord lining epithelial cells. Assay and Drug Development Technologies 11 (March 2013) 130  -138.
  5. LC Phua, M Mal, PK Koh, PY Cheah, ECY Chan* and HK Ho*. Investigating the roles of nucleoside transporters in the resistance of colorectal cancer to 5-fluorouracil therapy. Cancer Chemotherapy and Pharmacology 71 (March 2013) 817 – 823.
  6. LS New, TP Lim, JW Oh, GJS Cheah, AL Kwa and ECY Chan*. Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated clearance of rifampicin. Analytical and Bioanalytical Chemistry 405 (4) (January 2013) 1407 – 1415.

2012

  1. ZP Hu, ER Browne, T Liu, TE Angel, PC Ho and ECY Chan*. Metabonomic profiling of TASTPM transgenic Alzheimer’s disease mouse model. Journal of Proteome Research 11 (December 2012) 5903 – 5913.
  2. S Saha, DSZ Chan, CY Lee, W Wong, LS New, WK Chui, ECY Chan* and HK Ho*. Pyrrolidinediones reduce the toxicity of thiazolidinediones and modify their anti-diabetic and anti-cancer properties. European Journal of Pharmacology 697 (December 2012) 13 – 23.
  3. YL Teo, M Saetaew, S Chanthawong, YS Yap, ECY Chan, HK Ho and A Chan*. Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence. Breast Cancer Research and Treatment 133 (June 2012) 703 – 711.
  4. WPK Ching, SH Thng, AP Hui, DY Lee, ECY Chan* and YS Ho*. LC-MS-based metabolic characterization of high monoclonal antibody-producing chinese hamster ovary cells. Biotechnology and Bioengineering 109 (December 2012) 3103 – 3111.
  5. ECY Chan*, LS New, TB Chua, CW Yap, HK Ho and SD Nelson. Interaction of lapatinib with cytochrome P450 3A5. Drug Metabolism & Disposition40 (July 2012) 1414 – 1422.
  6. HT Chng, HK Ho, CW Yap, SH Lam and ECY Chan*. An investigation of the bioactivation potential and metabolism profile of zebrafish versus human. Journal of Biomolecular Screening 17 (August 2012) 974 – 986.
  7. ECY Chan*. Thomas O. Metz (Ed.): Metabolic profiling. Methods and protocols. Analytical Bioanalytical Chemistry 403 (July 2012) 2465 – 2466.
  8. M Mal, PK Koh, PY Cheah and ECY Chan*. Metabotyping of human colorectal cancer using two-dimensional gas chromatography mass spectrometry. Analytical Bioanalytical Chemistry 403 (April 2012) 483 – 493.

2011

  1. T Nema, ECY Chan and PC Ho*. Efficiency of a miniaturized silica monolithic cartridge in reducing matrix ions as demonstrated in the simultaneous extraction of morphine and codeine from urine samples for quantification with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Mass Spectrometry 46 (September 2011) 891 – 900.
  2. LY Chen, L Zhou*, ECY Chan*, J Neo and R Beuerman. Characterization of the human tear metabolome by LC-MS/MS. Journal of Proteome Research 10 (October 2011) 4876 – 4882.
  3. JCY Chan, LS New, HK Ho and ECY Chan*. Reversible time-dependent inhibition of cytochrome P450 enzymes by duloxetine and inertness of its thiophene ring towards bioactivation. Toxicology Letters 206 (October 2011) 314 – 324.
  4. KM Banday, KK Pasikanti, ECY Chan, R Singla, KVS Rao, VA Chauhan* and RK Nanda*. Use of urine volatile organic compounds could discriminate tuberculosis patients from healthy subjects. Analytical Chemistry 83 (2011) 5526 – 5534.
  5. ECY Chan*, KK Pasikanti and JK Nicholson. Global urinary metabolic profiling procedures using gas chromatography mass spectrometry. Nature Protocols 6 (October 2011) 1483 – 1499.
  6. T Nema, ECY Chan and PC Ho*. Extraction of ketamine from urine using a miniature silica monolithic cartridge followed by quantification with liquid chromatography tandem mass spectrometry (LC-MS/MS). Journal of Separation Science 10 (2011) 2079 – 2087.
  7. KL Chang, LS New, M Mal, CW Goh, CC AW, ER Browne and ECY Chan*. Metabolic profiling of 3-nitroproprionic acid early-stage Huntington’s disease rat model using gas chromatography time-of-flight mass spectrometry. Journal of Proteome Research 10 (2011) 2079 – 2087.
  8. H Takakusa, MD Wahlin, C Zhao, KL Hanson, LS New, ECY Chan and SD Nelson*. Metabolite-intermediate complex formation of human cytochrome P450 3A4 by lapatinib. Drug Metabolism & Disposition 39 (2011) 1022 – 1030.
  9. H Sukardi, HT Chng, ECY Chan, Z Gong and SH Lam*. Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism and Toxicology 7 (2011) 579 – 589.
  10. DF Toh, DN Patel, ECY Chan, A Yeo, SY Neo and HL Koh*. Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. Chinese Medicine 6 (2011) 1 – 9.
  11. M Mal, PK Koh, PY Cheah and ECY Chan*. UPLC/MS/MS targeted profiling of arachidonic acid and eicosanoids in human colorectal cancer. Rapid Communications in Mass Spectrometry 25 (2011) 755 – 764.
  12. DJY Ng, KK Pasikanti and ECY Chan*. Trend analysis of metabonomics and systemic review of metabonomics-derived cancer marker metabolites. Metabolomics 7 (2011) 155 – 178.

2010

  1. YT Koh, KK Pasikanti, CW Yap* and ECY Chan*. Comparative evaluation of software for retention time alignment of gas chromatography/time-of-flight mass spectrometry-based metabonomic data. Journal of Chromatography A 1217 (2010) 8308 – 8316.
  2. KK Pasikanti, J Norasmara, S Cai, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan*. Metabolic footprinting of tumorigenic and non-tumorigenic uroepithelial cells using two-dimensional gas chromatography time-of-flight mass spectrometry. Analytical and Bioanalytical Chemistry 398 (2010) 1285 – 1293.
  3. WC Teng, JW Oh, LS New, MD Wahlin, SD Nelson, HK Ho and ECY Chan*. Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib. Molecular Pharmacology 78 (2010) 693 – 703.
  4. T Nema, ECY Chan and PC Ho*. Application of silica based monolith as solid phase extraction cartridge for extracting polar compounds from urine. Talanta 82 (2010) 488 – 494.
  5. X Ma and ECY Chan*. On-line chromatographic screening of matrix metalloproteinase inhibitors using immobilized MMP-9 enzyme reactor. Journal of Chromatography B 878 (2010) 1777 – 1783.
  6. KK Pasikanti, K Esuvaranathan, PC Ho, R Mahendran, R Kamaraj, QH Wu, E Chiong and ECY Chan*. Noninvasive urinary metabonomic diagnosis of human bladder cancer. Journal of Proteome Research 9 (2010) 2988 – 2995.
  7. S Saha, LS New, HK Ho, WK Chui, ECY Chan*. Direct toxicity effects of sulfo-conjugated troglitazone on human hepatocytes. Toxicology Letters 195 (2010) 135 – 141.
  8. DF Toh, LS New, HL Koh* and ECY Chan*. Ultra-high performance liquid chromatography / time-of-flight mass spectrometry (UHPLC/TOFMS) for time-dependent profiling of raw and steamed Panax notoginsengJournal of Pharmaceutical and Biomedical Analysis 52 (2010) 43 – 50.
  9. S Saha, LS New, HK Ho, WK Chui and ECY Chan*. Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity. Toxicology Letters 192 (2010) 141 – 149.
  10. X Ma and ECY Chan*. Fluorescence-based liver microsomal assay for screening of pharmaceutical reactive metabolites using glutathione conjugated 96-well plates. Bioconjugate Chemistry 21 (2010) 46 – 55.
  11. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. A sensitive LC/MS/MS bioanalysis assay of orally-administered lipoic acid in rat blood and brain tissue. Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 754 – 757.

2009

  1. DPQ Goh, AH Neo, CW Goh, CC Aw, LS New, WS Chen, Z Atcha, ER Browne and ECY Chan*. Metabolic Profiling of Rat Brain and Cognitive Behavioral Tasks: Potential Complementary Strategies in Preclinical Cognition Enhancement Research. Journal of Proteome Research 8 (2009) 5679 – 5690.
  2. R  Kashimshetty, VG Desai, VM Kale, T Lee, CL Moland, WS Branham, LS New, ECY Chan, H Younis and UA Boelsterli*. Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity. Toxicology and Applied Pharmacology238 (2009) 150 – 159.
  3. M Mal, PK Koh, PY Cheah and ECY Chan*. Development and validation of a gas chromatography mass spectrometry (GC/MS) method for the metabolic profiling of human colon tissue. Rapid Communications in Mass Spectrometry 23 (2009) 487 – 494.
  4. ECY Chan*, LS New, CW Yap and LT Goh. Pharmaceutical metabolite profiling using quadrupole/ ion mobility spectrometry/ time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry 23 (2009) 384 – 394.
  5. ECY Chan*, PK Koh, M Mal, PY Cheah, KW Eu, A Backshall, R Cavill, JK Nicholson and H Keun. Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas chromatography mass spectrometry (GC/MS). Journal of Proteome Research 8 (2009) 351 – 361.
  6. HT Chng, LS New, AH Neo, CW Goh, ER Browne and ECY Chan*. Distribution study of orally administered lipoic acid in rat brain tissues. Brain Research 1251 (2009) 80 – 86.

2008

  1. KK Pasikanti, PC Ho and ECY Chan*. Development and validation of a GC/MS metabonomic platform for the global profiling of urinary metabolites. Rapid Communications in Mass Spectrometry 22 (2008) 2984 – 2992.
  2. LC Phua, LS New, CW Goh, AH Neo, ER Browne and ECY Chan*. Investigation of the drug-drug Interaction between α-lipoic Acid and valproate via mitochondrial β-oxidation. Pharmaceutical Research 25 (2008) 2639 – 2649.
  3. WS Law, PY Huang, ES Ong*, CN Ong, SFY Li, KK Pasikanti, ECY Chan. Metabonomics investigation of human urine after ingestion of green tea with gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry and 1H NMR spectroscopy. Rapid Communications in Mass Spectrometry 22 (2008) 2436 – 2446.
  4. SC Tan, LS New and ECY Chan*. Prevention of acetaminophen (APAP) induced hepatotoxicity by leflunomide via inhibition of APAP biotransformation to N-acetyl-p-benzoquinone imine. Toxicology Letters 180 (2008) 174 – 81.
  5. QM Seah, LS New, ECY Chan, UA Boelsterli*. Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77-1726. Drug Metabolism Letters 2 (2008) 153 – 57.
  6. KK Pasikanti, PC Ho and ECY Chan*. Gas Chromatography/Mass Spectrometry in Metabolic Profiling of Biological Fluids. Journal of Chromatography B 871 (2008) 202 – 211. Top 25 Most Cited Review Article (2008-2009)
  7. LS New and ECY Chan*.Evaluation of BEH C18, BEH HILIC and HSS T3 (C18) Column Chemistries for the UPLC/MS/MS Analysis of Glutathione, Glutathione Disulfide and Ophthalmic Acid in Mouse Liver and Human Plasma.  Journal of Chromatographic Science 48 (2008) 209 – 214 (Special UPLC Issue).

1998 - 2007

  1. ECY Chan* and LS New. In Vitro Metabolism of Leflunomide by Mouse and Human Liver Microsomes. Drug Metabolism Letters 1 (2007) 299 – 305.
  2. LS New, S Saha, MMK Ong, UA Boelsterli and ECY Chan*. Pharmacokinetic Study of Intraperitoneal Administered Troglitazone in Mice Using UPLC/MS/MS. Rapid Communications in Mass Spectrometry 21 (2007) 982 – 988.
  3. ECY Chan*, SL Yap, AJ Lau, PC Leow, DF Toh and HL Koh. UPLC/TOFMS Based Metabolomics of Raw and Steamed Panax notoginseng. Rapid Communications in Mass Spectrometry 21 (2007) 519 – 528.
  4. HL Koh*, AJ Lau and ECY Chan.  Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (b-N-oxalyl-L-a,b-diaminopropionic acid) in Panax medicinal plant species. Rapid Communications in Mass Spectrometry 9 ( 2005) 1237 -1 244.
  5. ECY Chan*, TW Lee, PC Ho and LJ Fang. Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors. Journal of Chromatography A 1072 (2005) 159 – 168.
  6. L Bo and ECY Chan*. Application of visual basic in high-throughput mass spectrometry-directed purification of combinatorial libraries. Journal of Combinatorial Chemistry 5 (2003) 834 – 841.
  7. ECY Chan and PC Ho*. Preparation and characterization of immunogens for antibody production against metanephrine and normetanephrine. Journal of Immunological Methods 266 (2002) 143 – 154.
  8. ECY Chan*, AW Wang, WP Jia and GD Dollinger. An automated LC method for the small-scale purification of organic molecules derived from combinatorial libraries.Journal of Pharmaceutical and Biomedical Analysis 29 (2002) 139 – 146.
  9. ECY Chan and PC Ho*. High-performance liquid chromatography/atmospheric pressure chemical ionization mass spectrometric method for the analysis of catecholamines and metanephrines in human urine. Rapid Communications in Mass Spectrometry 14 (2000) 1959 – 1964.
  10. ECY Chan, PY Wee, PY Ho and PC Ho*. High-performance liquid chromatographic assay for catecholamines and metanephrines using fluorimetric detection with pre-column 9-fluorenylmethyloxycarbonyl chloride derivatization. Journal of Chromatography B 749 (2000) 179 – 189
  11. ECY Chan, PY Wee and PC Ho*. Evaluation of degradation of urinary catecholamines and metanephrines and deconjugation of their sulfoconjugates using stability-indicating reversed-phase ion-pair HPLC with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 22 (2000) 515 – 526.
  12. ECY Chan, PY Wee and PC Ho*. The value of analytical assays that are stability-indicating. Clinica Chimica Acta 288 (1999) 47 – 53.
  13. ECY Chan and PC Ho*. Enantiomeric separation of tramadol hydrochloride and its metabolites by cyclodextrin-mediated capillary zone electrophoresis. Journal of Chromatography B 707 (1998) 287 – 294.

 

 

Thank you for your interest, the following position is closed.

Clinical Trial Officer in the Department of Urology/Surgery, Yong Loo Lin School of Medical.

Department of Urology, Surgery, is reputed for conducting multi-disciplinary research in many areas including translational research. In this research project, the PI is collaborating with the Department of Pharmacy, NUS. Appointment will be made on a one-year contract, with the possibility of extension.

The Clinical Trial Officer (CTO) will be responsible to, and work closely with, the Principal Investigator and study team members to ensure the successful completion of the trial on time. The CTO’s principal role will be to work in Clinical Research conducted according to SGGCP guidelines.

 

Main duties and responsibilities

The Clinical Trial Officer will liaise with the relevant personnel in NUH, NUS and other institutions and will be accountable to the Principle Investigator (PI).

The CTO will be able to:

  1. Oversee the general management of the project;
  2. Provide administrative and secretarial support to the project, such as organizing regular meetings to maintain regular communication with other members of the research team;
  3. Undertake the day to day running of the project at the study site, e.g. screening and recruiting patients, documentation of processes related to the projects, data collection and documentation, submitting reports to regulatory authorities and sponsor
  4. Maintain the highest standard of professional conduct and record keeping in accordance with SGGCP guidelines;
  5. Assist with any other duties of a similar nature that are delegated by the PI.

 

Requirement

The applicant should:

  1. Have a basic degree in biochemistry/life sciences or related disciplines or nursing degree; preferably with some experience in clinical research;
  2. Be able to work independently and in a team, have an investigative nature, attention to detail; and
  3. Have knowledge of computer applications, e.g. SPSS, MS office, PowerPoint.

 

Remuneration will be commensurate with the candidate’s qualifications and experience. Informal enquiries are welcome and should be made to Dr Lata Raman, at 67725643.

 

Formal application: Please submit your application, indicating current/expected salary, supported by a detailed CV (including personal particulars, academic and employment history, complete list of publications/oral presentations and full contacts of three referees to:

 

surlmm@nus.edu.sg

Kindly email us via the “People” tab.

Address: 6 Science Drive 3 Singapore 117554, Science Blk 7 Level 2