Laboratory of Drug Metabolism and Toxicology

The overall goal of the research program is to enhance understanding of the molecular and cellular mechanisms of bioactivation and detoxification of drugs and endogenous chemicals, and how various patient-specific factors affect drug disposition, efficacy, and toxicity.

 

A) Regulation of Drug-Metabolizing Enzymes Expression and Function
Drug-metabolizing enzymes are expressed in various tissues, but most of them are present predominantly in the liver. These large diverse groups of enzymes play a significant role in the bioactivation and detoxification of drugs and other chemicals. Studies are ongoing to characterize a select group of human cytosolic drug-metabolizing enzymes (e.g. aldehyde oxidases, sulfotransferases) in health and disease, and identify factors that regulate their expression and function.

 

B) Pharmacological and Toxicological Consequences of Nuclear Receptor Modulation

Nuclear receptors are DNA-binding transcription factors that regulate the expression of a broad array of genes involved in various physiological and pathophysiological processes, including metabolism and transport of drugs and other chemicals. Current studies include identifying drugs and other chemicals that modulate the function of nuclear receptors and how they affect the detoxification processes of endogenous chemicals (e.g. bile acids).

Aik Jiang LAU, Ph.D.
Assistant Professor
Department of Pharmacy, Faculty of Science
National University of Singapore
#S7-02-15, 18 Science Drive 4
Singapore 117543
Phone: +65 6601 3470; Fax: +65 6779 1554; Email: aikjiang.lau@nus.edu.sg


EDUCATION

Doctor of Philosophy
Department of Pharmacy, Faculty of Science, National University of Singapore

B. Sc. (Honours) (Pharmacy)
Department of Pharmacy, Faculty of Science, National University of Singapore


PROFESSIONAL QUALIFICATION

Registered Pharmacist, Singapore Pharmacy Board


EMPLOYMENT RECORD

Assistant Professor (Joint Appointment)
June 2013 to present
Department of Pharmacy, Faculty of Science
National University of Singapore

Assistant Professor (Joint Appointment)
June 2013 to present
Department of Pharmacology, Yong Loo Lin School of Medicine
National University of Singapore

Postdoctoral Research Fellow
November 2007 to May 2013
Faculty of Pharmaceutical Sciences
The University of British Columbia
Vancouver, British Columbia, Canada

University Instructor
July 2007 to October 2007
Department of Pharmacy, Faculty of Science
National University of Singapore

University Teaching Assistant (Full-time)
August 2005 to June 2007
Department of Pharmacy, Faculty of Science
National University of Singapore

Hospital Pharmacy Residency (Pre-registration Pharmacist)
2000-2001
National University Hospital, Singapore

Principal Investigator

Award Year
Postdoctoral Scientist Award
Division of Drug Metabolism
American Society of Pharmacology and Experimental Therapeutics (ASPET)
Experimental Biology Annual Meeting, San Diego, California, USA

April 2012

Young Scientist Travel Award
American Society of Pharmacology and Experimental Therapeutics (ASPET)
Experimental Biology Annual Meeting, San Diego, California, USA
April 2012
Emil A. Pfitzer Postdoctoral Award
Drug Discovery Toxicology Specialty Section (DDTSS)
Society of Toxicology (SOT) Annual Meeting, San Francisco, California, USA
March 2012
Best Presentation Award – Postdoctoral category
International Society for the Study of Xenobiotics (ISSX)
4th Asia-Pacific Regional Meeting, Tainan, Taiwan
April 2011
Young Scientist Travel Award
American Society of Pharmacology and Experimental Therapeutics (ASPET)
Experimental Biology Annual Meeting, Anaheim, California, USA
April 2010
Postdoctoral Fellow Travel Award
Regulatory and Safety Evaluation Specialty Section (RSESS)
Society of Toxicology (SOT) Annual Meeting, Salt Lake City, Utah, USA
March 2010
Best Poster Award (1st prize) PharmSci@Asia Symposium, Fudan University, China June 2007
Sponsorship from Novartis International AG
Novartis International Biotechnology Leadership Camp
International BioCamp, Singapore
October 2006
Faculty of Science Best Graduate Researcher Award (Pharmacy)
National University of Singapore
2005
Outstanding Graduate Research Award
Pharmacy Honours Day, National University of Singapore
2005
Best Presenter Award
The Inaugural AAPS-NUS Student Chapter Symposium, Singapore
September 2005
Best Presenter Award for Pharmaceutical and Medicinal Chemistry section
Inaugural Inter-varsity Symposium, 17th Singapore Pharmacy Congress, Singapore
July 2005
Best Presenter Award for Pharmaceutical Chemistry section
Pharmacy Graduate Seminar III, Singapore
May 2004
Best Poster Award (1st prize)
16th Singapore Pharmacy Congress, Singapore
November 2003
Graduate Research Scholarship (Ph.D.)
National University of Singapore
2001-2005

 

Research-related Awards from Mentees

Award Student /

Research Fellow

Year
Lijen Industrial Development Medal
Top undergraduate final year project in the class
National University of Singapore
Caleb Yip Keng Yan
(Undergraduate student)
July 2016
Best Presentation Award (Third Prize) in the Graduate Student category
International Society for the Study of Xenobiotics (ISSX)
11th International Meeting, Busan, South Korea
Chen Shiyan
(Graduate student)
June 2016
First Prize for Undergraduate Final Year Project (Pharmacokinetics Domain)
Annual Pharmacy Research Awareness Symposium
National University of Singapore
Caleb Yip Keng Yan
(Undergraduate student)
April 2016

Research Fellows

Academic Year

Fellow

Project Topic

Supervisor
2016 – 2018 Wong Siew Ying National Medical Research Council – Collaborative Basic Research Grant: Effect of tocotrienols, a class of therapeutically-active vitamin E, on biotransformation and toxicity of secondary bile acids AJ Lau
2016 – 2018 Cassandra Yap Agency for Science Technology and Research (A*STAR)-Procter & Gamble Grant: 3D printing of fully customizable pills for personalized healthcare.

This is an interdisciplinary, collaborative, and industry-sponsored project conducted together with collaborators in the Department of Chemical and Biomolecular Engineering, National University of Singapore and Procter & Gamble International Operations SA SG Branch, Singapore.

AJ Lau

 

Graduate Students

Academic Year Student Project Title Supervisor
2015 – 2019 Chen Shiyan Regulation of human aldehyde oxidase-1 AJ Lau
2014 – 2017 Sumit Bansal Effect of selective estrogen receptor modulators on lithocholic acid metabolism AJ Lau

 

Undergraduate Final Year Project Students (Pharmacy)

Academic Year Student Project Title Supervisor
2016 – 2017 Yvonne Ng Wan Xin Effect of anti-androgens on sulfotransferase 2A1-catalyzed lithocholic acid sulfation AJ Lau
2016 – 2017 Tan Wee Kiat Inhibition of human aldehyde oxidase-1 activity AJ Lau
2016 – 2017 Xie Jiarong Metabolic reactions of human aldehyde oxidase-1 AJ Lau

 

Undergraduate Final Year Project Students (Life Sciences)

Academic Year Student Project Title Supervisor
2016 – 2017 Tay Shi Han Regulation of human aldehyde oxidase-1 by aryl hydrocarbon receptor modulators AJ Lau

Undergraduate Final Year Project Students (Pharmacy)

Academic Year Student Project Title Supervisor
2015 – 2016 Nur Fazilah D/O Saburulla Metabolic reactions of human aldehyde oxidase-1 AJ Lau
2015 – 2016 Josephine Teo Si Min Effect of vitamin E on lithocholic acid metabolism AJ Lau
2015 – 2016 Caleb Yip Keng Yan Evaluation of species-, tissue-, and sex-dependency in sulfotransferase 2A1-catalyzed dehydroepiandrosterone sulfation and lithocholic acid sulfation AJ Lau
2014 – 2015 Chai Swee Fen Effect of tocotrienols on the metabolism of lithocholic acid to 3-ketocholanic acid AJ Lau
2014 – 2015 Tay Hwee Ying Mechanism-based inactivation of human CYP3A4 catalytic activity by meclizine AJ Lau & ECY Chan
2013 – 2014 Winnie Foo Yin Bing Inhibition of cytochrome P450 3A by meclizine, a human pregnane X receptor agonist AJ Lau & ECY Chan

 

Undergraduate Final Year Project Students (Life Sciences)

Academic Year Student Project Title Supervisor
2014 – 2015 Ferny Wong Xiaoyin ABC transporters in dementia MKP Lai & AJ Lau
2014 – 2015 Oh Wan Ling Expression of sulfotransferases in human brain tissues: Effects of Alzheimer’s disease AJ Lau & MKP Lai
2014 – 2015 Seow Chun Ling Assessment of carnosic acid, ursolic acid, rosmarinic acid, and carnosol as activators of pregnane X receptor AJ Lau

Updated list is at: https://www.ncbi.nlm.nih.gov/pubmed/?term=lau+aj

 

Refereed, Primary Research Articles

  1. Bansal S, Chai SF, Lau AJ. An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay. Journal of Chromatography B, 2016, 1023-1024: 1-8.
  2. Bansal S, Lau AJ. Fast and sensitive quantification of human liver cytosolic lithocholic acid sulfation using ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2016, 1011: 171-178.
  3. Bansal S, Lau AJ. Human liver cytosolic sulfotransferase 2A1-dependent dehydroepiandrosterone sulfation assay by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2016, 120: 261-269.
  4. Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TKH, Mani S, Hirota SA. Pregnane X receptor activation attenuates inflammation-associated intestinal epithelial barrier dysfunction by inhibition cytokine-induced MLCK expression and JNK1/2 activation. Journal of Pharmacology and Experimental Therapeutics, 2016, 359: 91-101.
  5. Lau AJ, Politi R, Yang G, Chang TKH. Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. Journal of Steroid Biochemistry and Molecular Biology, 2016, 163: 59-67.
  6. Foo WYB, Tay HY, Chan ECY, Lau AJ. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochemical Pharmacology, 2015, 97: 320-330.
  7. Lau AJ, Chang TKH. 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. Pharmacological Research, 2015, 100: 64-72.
  8. Sharma D, Lau AJ, Sherman MA, Chang TKH. Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine. British Journal of Pharmacology, 2015, 172: 1263-1276.
  9. Lau AJ, Chang TKH. Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicology and Applied Pharmacology, 2014, 277: 221-230.
  10. Lau AJ, Chang TKH. Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: Analysis with 3-hydroxyflavone and its analogues. British Journal of Pharmacology, 2013, 170: 403-414.
  11. Sharma D, Lau AJ, Sherman MA, Chang TKH. Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors. Biochemical Pharmacology, 2013, 85: 1700-1711.
  12. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. Journal of Ethnopharmacology, 2013, 145: 670-675.
  13. Lau AJ, Yang G, Yap CW, Chang TKH. Selective agonism of human pregnane X receptor by individual ginkgolides. Drug Metabolism and Disposition, 2012, 40: 1113-1121.
  14. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor. Drug Metabolism and Disposition, 2012, 40: 178-186.
  15. Lau AJ, Yang G, Chang TKH. Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: Functional analysis of the SV23, SV24, and SV25 splice variants. Journal of Pharmacology and Experimental Therapeutics, 2011, 339: 704-715.
  16. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. Journal of Pharmacology and Experimental Therapeutics, 2011, 336: 816-826.
  17. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Human pregnane X receptor agonism by Ginkgo biloba extract: Assessment of the role of individual ginkgolides. Journal of Pharmacology and Experimental Therapeutics, 2010, 335: 771-780.
  18. Lau AJ and Chang TKH. Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: Effect of terpene trilactones and flavonols. Drug Metabolism and Disposition, 2009, 37: 1931-1937.
  19. Ching J, Chua TK, Chin LC, Lau AJ, Pang YK, Jaya JM, Tan CH, Koh HL. Beta-amyrin from Ardisia elliptica Thunb. is more potent than aspirin in inhibiting collagen-induced platelet aggregation. Indian Journal of Experimental Biology, 2010, 48: 275-279.
  20. Lau AJ, Chua TK, Pang YK, Toh DF, Koh HL. Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with other Panax species. Journal of Ethnopharmacology, 2009, 125: 380-386.
  21. Chui WK, Pastorin G, Lau AJ. Learning the use of medicinal herbs in phytotherapy: A tripartite approach for pharmacy students. Pharmacy Education, 2009, 9 (1), May 10.
  22. Chan ECY, Yap SL, Lau AJ, Leow PC, Toh DF, Koh HL. Ultra-performance liquid chromatography/ time-of-flight mass spectrometry based metabolomics of raw and steamed Panax notoginseng. Rapid Communications in Mass Spectrometry, 2007, 21: 519-528.
  23. Hong DYQ, Lau AJ, Yeo CL, Liu XK, Yang CR, Koh HL, Hong Y. Genetic diversity and variation of saponin contents in Panax notoginseng roots from a single farm. Journal of Agricultural and Food Chemistry, 2005, 53: 8460-8467.
  24. Koh HL, Lau AJ, Chan ECY. Hydrophilic interaction liquid chromatography with tandem mass spectrometry for the determination of underivatized dencichine (-N-oxalyl-L-,-diaminopropionic acid) in Panax medicinal plant species. Rapid Communications in Mass Spectrometry, 2005, 19: 1237-1244.
  25. Lau AJ, Seo BH, Woo SO, Koh HL. High-performance liquid chromatographic method with quantitative comparisons of whole chromatograms of raw and steamed Panax notoginseng. Journal of Chromatography A, 2004, 1057: 141-149.
  26. Lau AJ, Woo SO, Koh HL. Analysis of saponins in raw and steamed Panax notoginseng using high performance liquid chromatography with diode array detection. Journal of Chromatography A, 2003, 1011: 77-87.
  27. Lau AJ, Holmes MJ, Woo SO, Koh HL. Analysis of adulterants in a traditional herbal medicinal product using LC-MS-MS. Journal of Pharmaceutical and Biomedical Analysis, 2003, 31: 401-406.

 

Book Chapter

  1. Lau AJ and Koh HL. Quality control of herbs: principles and procedures, using Panax as an example. In: Leung PC, Fong H, Xue CCL, eds. Annals of Traditional Chinese Medicine, Current review of Chinese medicine—quality control of herbs and herbal materials, 2006, volume 2, 87-115.

 

Conference Proceedings / Abstracts

  1. Chen S, Lau AJ. Comparison of the inhibitory effects of selective estrogen receptor modulators, tyrosine kinase inhibitors, and steroidal drugs on human aldehyde oxidase activity. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016. [Best Presentation Award (Third Prize) – Graduate Student Category; Poster and Oral Presentations]
  2. Bansal S, Lau AJ. Differential inhibition of sulfotransferase 2A1 by selective estrogen receptor modulators. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016.
  3. Saburulla NF, Lau AJ. Carbazeran 4-oxidation is catalyzed by human aldehyde oxidase-1 but not cytochrome P450 enzymes in human liver microsomes. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016.
  4. Yip CKY, Lau AJ. Inhibition of human liver cytosolic sulfotransferase 2A1-dependent dehydroepiandrosterone sulfation by steroidal anti-androgens. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016. [1. First prize winner in the Pharmacokinetics Domain (Undergraduate Final Year Project), Annual Pharmacy Research Awareness Symposium, Department of Pharmacy, National University of Singapore; and 2. Lijen Industrial Development Medal, National University of Singapore]
  5. Yip CKY, Lau AJ. Cytosolic sulfotransferases-catalyzed dehydroepiandrosterone sulfation: Evaluation of sex, tissue, and species. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016. [1. First prize winner in the Pharmacokinetics Domain (Undergraduate Final Year Project), Annual Pharmacy Research Awareness Symposium, Department of Pharmacy, National University of Singapore; and 2. Lijen Industrial Development Medal, National University of Singapore]
  6. CL Seow, Lau AJ. Differential activation of human, mouse, and rat pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid in rosemary extract. International Society for the Study of Xenobiotics, 11th International Meeting, Busan, South Korea, 12-16 June 2016. Published in Drug Metabolism Reviews 2016.
  7. Lau AJ, Chai SF, Teo JSM. Tocotrienols, but not alpha-tocopherol, inhibit CYP3A-catalyzed lithocholic acid 3-oxidation. Experimental Biology Annual Meeting, San Diego, California, U.S.A., 2-6 April 2016. Published in FASEB Journal 2016, 30: 934.5.
  8. Chai SF, Bansal S, Lau AJ. Substrate-dependent inhibition of human cytochrome P450 3A catalytic activity by specific isomers of vitamin E. The IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine, Singapore, 22-24 July 2015. Published in Chinese Journal of Pharmacology and Toxicology 2015, 29 (Supplement 1), 107-108.
  9. Bansal S and Lau AJ. Quantification of dehydroepiandrosterone sulphate and lithocholic acid sulphate by ultra-high performance liquid chromatography-tandem mass spectrometry. AAPS-NUS Student Chapter 10th PharmSci@Asia, Singapore, 8-9 April 2015.
  10. Lau AJ, Yang G, Chang TKH. Comparative analysis of quercetin and its structurally-related analogues on activation of rat and human vitamin D receptor. Society of Toxicology 54th Annual Meeting, San Diego, California, U.S.A., 22-26 March 2015. Published in The Toxicologist 2015, 144 (Issue 1): 2321.
  11. Foo WYB, Chan ECY, Lau AJ. Meclizine, a pregnane X receptor agonist, is an inhibitor of cytochrome P450 3A enzyme activity. International Society for the Study of Xenobiotics, 19th North American Regional Meeting, San Francisco, California, U.S.A., 19-23 October 2014. Published in Drug Metabolism Reviews 2015, 47 (Supplement 1): P202.
  12. Sharma D, Lau AJ, Sherman MA, Chang TKH. Effect of rilpivirine and etravirine on the activity of human constitutive androstane receptor and its SV23 and SV24 splice variants. American Association of Pharmaceutical Scientists Annual Meeting and Exposition, San Diego, California, U.S.A., 2-6 November 2014.
  13. Lau AJ and Chang TKH. Ginkgo biloba extract potentiates human vitamin D receptor-mediated increase in CYP2B6 reporter activity by 1α,25-dihydroxyvitamin D3. Experimental Biology Annual Meeting, San Diego, California, U.S.A., 26-30 April 2014. Published in FASEB Journal 2014, 28: 1141.8.
  14. Lau AJ and Chang TKH. Fetal bovine serum influences the effect of a ligand on the activity of the SV23 splice variant of human constitutive androstane receptor. Experimental Biology Annual Meeting, San Diego, California, U.S.A., 26-30 April 2014. Published in FASEB Journal 2014, 28: 1148.1.
  15. Sharma D, Lau AJ, Sherman MA, Chang TKH. Agonism of human pregnane X receptor by rilpivirine and etravirine: Comparison with first generation non-nucleoside reverse transcriptase inhibitors. Canadian Society for Pharmaceutical Sciences, Vancouver, British Columbia, Canada, 11-14 June 2013.
  16. Lau AJ and Chang TKH. Functional analysis of splice variants of human constitutive androstane receptor: Investigation with flavonol (3-hydroxyflavone) and its metabolites. Experimental Biology Annual Meeting, Boston, Massachusetts, U.S.A., 20-24 April 2013. Published in FASEB Journal 2013, 27: 1102.9.
  17. Lau AJ and Chang TKH. Selective activation of human pregnane X receptor, vitamin D receptor, and glucocorticoid receptor by flavonols. Society of Toxicology 52nd Annual Meeting, San Antonio, Texas, U.S.A., 10-14 March 2013. Published in The Toxicologist 2013, 132 (Issue 1): 1275.
  18. Lau AJ and Chang TKH. Differential effect of galangin and its hydroxylated metabolites on the activity of various isoforms of human constitutive androstane receptor. International Society for the Study of Xenobiotics, 18th North American Regional Meeting, Dallas, Texas, U.S.A., 14-18 October 2012. Published in Drug Metabolism Reviews 2012, 44 (Supplement 1): P218.
  19. Lau AJ and Chang TKH. Comparison of galangin and flavonol on activation of the human pregnane X receptor: Effect of C5 and C7 hydroxylation of flavonol. Mechanism-Based Natural Product Development Conference, Whistler, British Columbia, Canada, 21-22 September 2012.
  20. Lau AJ, Yang G, Yap CW, Chang TKH. Regulation of human pregnane X receptor function by individual ginkgolides. Experimental Biology Annual Meeting, San Diego, California, U.S.A., 21-25 April 2012. Published in FASEB Journal 2012, 26: 673.4. [American Society of Pharmacology and Experimental Therapeutics (ASPET) Young Scientist Travel Award; and Postdoctoral Scientist Award from the Drug Metabolism Division of ASPET]
  21. Lau AJ, Yang G, Chang TKH. Functional analysis of the SV23, SV24, and SV25 splice variants of human constitutive androstane receptor (CAR): Comparison of Ginkgo biloba extract with other known activators of CAR. Society of Toxicology 51st Annual Meeting, San Francisco, California, U.S.A., 11-15 March 2012. Published in The Toxicologist 2012, 126 (Issue 1): 179. [Emil A. Pfizter Postdoctoral Award]
  22. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Induction of a human constitutive androstane receptor target gene (CYP2B6) by Ginkgo biloba extract is independent of the glucocorticoid receptor. International Society for the Study of Xenobiotics, 4th Asia Pacific Regional Meeting, Tainan, Taiwan, 22-25 April 2011. Published in Drug Metabolism Reviews 2011, 43 (Supplement 1): 26-27. [Best Presentation Award – Postdoctoral Research]
  23. Lau AJ, Yang G, Chang TKH. Ginkgo biloba extract differentially activates the SV23 and SV25 splice variants of human constitutive androstane receptor. International Society for the Study of Xenobiotics, 4th Asia Pacific Regional Meeting, Tainan, Taiwan, 22-25 April 2011. Published in Drug Metabolism Reviews 2011, 43 (Supplement 1): 77.
  24. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Meclizine is not an inverse agonist or antagonist of human constitutive androstane receptor. Experimental Biology Annual Meeting, Washington, D.C., U.S.A., 9-13 April 2011. Published in FASEB Journal 2011, 25: 1014.7.
  25. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Meclizine is an agonist of human pregnane X receptor. Experimental Biology Annual Meeting, Washington, D.C., U.S.A., 9-13 April 2011. Published in FASEB Journal 2011, 25: 1014.5.
  26. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Species-dependent and receptor-selective effect of bilobalide on the activity of constitutive androstane receptor and pregnane X receptor. Society of Toxicology 50th Annual Meeting, Washington, D.C., U.S.A., 6-10 March 2011. Published in The Toxicologist 2011, 120 (Supplement 2): 377.
  27. Lau AJ, Rajaraman G, Baucom CC, Yang G, Chang TKH. Differential role of ginkgolide A and bilobalide in the modulation of CYP3A and CYP2B6 expression by Ginkgo biloba extract in primary cultures of human hepatocytes. Experimental Biology Annual Meeting, Anaheim, California, U.S.A., 24-28 April 2010. Published in FASEB Journal 2010, 24: 757.6. [American Society of Pharmacology and Experimental Therapeutics (ASPET) Young Scientist Travel Award]
  28. Lau AJ and Chang TKH. Differential activation of rat and human pregnane X receptor by terpene trilactones. Experimental Biology Annual Meeting, Anaheim, California, U.S.A., 24-28 April 2010. Published in FASEB Journal 2010, 24: 757.5. [American Society of Pharmacology and Experimental Therapeutics (ASPET) Young Scientist Travel Award]
  29. Lau AJ and Chang TKH. Partial contribution of ginkgolide A to rat and human pregnane X receptor activation by Ginkgo biloba extract. Society of Toxicology 49th Annual Meeting, Salt Lake City, Utah, U.S.A., 7-11 March 2010. Published in The Toxicologist 2010, 114 (Number 1): 1133. [Society of Toxicology Postdoctoral Fellow Travel Award]
  30. Lau AJ and Chang TKH. Interaction between Ginkgo biloba extract and bupropion. 6th Natural Health Product Research Conference, Vancouver, Canada, 18-21 February 2009. Published in Pharmaceutical Biology 2009, 47 (Supplement 1): 31.
  31. Lau AJ, Chua TK, Pang YK, Koh HL. Comparative study of the antiplatelet and anticoagulant activities of different Panax species. AAPS-NUS Student Chapter PharmSci@Asia Symposium, Fudan University, China, 28 June 2007. [Best Poster Award- 1st Prize]
  32. Lau AJ, Chua TK, Pang YK, Koh HL. Platelet aggregation and blood coagulation inhibitory activities of Panax species. Office of Life Sciences Conference, Singapore, 5-6 February 2007.
  33. Lau AJ, Yeo CL, Hong DYQ, Liu XK, Yang CR, Hong Y, Koh HL. A study on the saponin contents and genetic diversity in individual Panax notoginseng roots from a good agricultural practice farm. 18th Singapore Pharmacy Congress, Singapore, 1-2 July 2006.
  34. Lau AJ, Chan EC, Koh HL. Analysis of dencichine, a haemostatic agent, in Panax species using hydrophilic interaction chromatography-tandem mass spectrometry. Inaugural AAPS-NUS Student Chapter Symposium, Singapore, 16 September 2005. [Best Presenter Award]
  35. Lau AJ, Chan EC, Koh HL. Liquid chromatography-tandem mass spectrometry for the determination of dencichine, a haemostatic agent in Panax medicinal plant species. Inaugural Inter-varsity Symposium, 17th Singapore Pharmacy Congress, Singapore, 1-3 July 2005. [Best Presenter Award for the Pharmaceutical and Medicinal Chemistry section]
  36. Lau AJ, Tanaka N, Chan EC, Koh HL. Determination of dencichine in Panax species using liquid chromatography-tandem mass spectrometry. Inaugural International Congress on Complementary and Alternative Medicines (ICCAM), Singapore, 26-28 February 2005.
  37. Lau AJ, Seo BH, Woo SO, Koh HL. Chromatographic pattern matching of raw and steamed Panax notoginseng. 15th International Symposium on Pharmaceutical and Biomedical Analysis, Florence, Italy, 2-6 May 2004.
  38. Lau AJ, Seo BH, Woo SO, Koh HL. Chromatographic pattern matching of Panax notoginseng, a Chinese herbal medicine. 16th Singapore Pharmacy Congress, Singapore, 22-23 November 2003. [Best Poster Award- 1st Prize]
  39. Koh HL, Lau AJ, Seo BH, Woo SO. Differentiation of raw and steamed Panax notoginseng using HPLC with chromatographic pattern matching. The 1st World Congress on Chinese Medicine, Melbourne, Australia, 21-24 November 2003.
  40. Lau AJ, Woo SO, Koh HL. Analysis of raw and steamed Panax notoginseng using HPLC-DAD. AAPS Annual Meeting and Exposition, Toronto, Canada, 10-14 November 2002.
  41. Koh HL, Lau AJ, Nah LJ, Woo SO. Prevalence of laxatives in over the counter slimming products. 5th American Chinese Pharmaceutical Association (ACPA) International Conference, Singapore, 28-30 May 2001.

 

Patents and Intellectual Property Rights

  1. Koh HL and Lau AJ. Anti-thrombotic activities of extracts and components from raw and steamed Panax notoginseng, US Provisional Patent, No. 60/828,078, 4 Oct 2006.

 

Other Contributions

  1. Member of Editorial Committee, Zhao ZZ and Xiao PG (eds). The Encyclopaedia of Contemporary Medicinal Plants, Volumes 1 to 4, Hong Kong Jockey Club Institute of Chinese Medicine Ltd, Shanghai World Publishing Corporation, 2009.