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Assistant Professor LAU Aik Jiang

B.Sc. (Pharm) (Honours), National University of Singapore
Ph.D., National University of Singapore
Postdoctoral Fellowship, The University of British Columbia, Vancouver, B.C., Canada

Department of Pharmacy, National University of Singapore
18 Science Drive 4, Singapore 117543
Tel: +65 6601 3470
Fax: +65 6779 1554
Email: aikjiang.lau@nus.edu.sg
Research Website

Teaching Activities in NUS

  • PA1113 Basic Pharmacology (Pharmacy)
    • Basic Pharmacokinetics, ADME, PK/PD, Pharmacogenetics, Drug Interactions, Toxicology/ADR
  • MD2140 Medical Pharmacology (MBBS Phase II)
    • Basic Pharmacokinetics, ADME
  • PR2143 Pharmaceutical Analysis for Quality Assurance
  • PR5222 Drug Metabolism
  • MDG5204 Advanced Topics in Pharmacology
    • Basic Pharmacokinetics, Pharmacodynamics
  • Assistant Professor, Department of Pharmacy, Faculty of Science, National University of Singapore
  • Assistant Professor, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore

The overall goal of the research program is to enhance understanding of the molecular and cellular mechanisms of bioactivation and detoxification of drugs and endogenous chemicals, and how various patient-specific factors affect drug disposition, efficacy, and toxicity.

  • Regulation of drug-metabolizing enzymes expression and function
  • Pharmacological and toxicological consequences of nuclear receptor modulation
  1. Bansal S, Chai SF, Lau AJ. An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay. Journal of Chromatography B, 2016, 1023-1024: 1-8.
  2. Bansal S, Lau AJ. Fast and sensitive quantification of human liver cytosolic lithocholic acid sulfation using ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 2016, 1011: 171-178.
  3. Bansal S, Lau AJ. Human liver cytosolic sulfotransferase 2A1-dependent dehydroepiandrosterone sulfation assay by ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2016, 120: 261-269.
  4. Foo WYB, Tay HY, Chan ECY, Lau AJ. Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A. Biochemical Pharmacology, 2015, 97: 320-330.
  5. Lau AJ, Chang TKH. 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. Pharmacological Research, 2015, 100: 64-72.
  6. Lau AJ, Chang TKH. Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicology and Applied Pharmacology, 2014, 277: 221-230.
  7. Lau AJ, Chang TKH. Indirect activation of the SV23 and SV24 splice variants of human constitutive androstane receptor: Analysis with 3-hydroxyflavone and its analogues. British Journal of Pharmacology, 2013, 170: 403-414.
  8. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. Journal of Ethnopharmacology, 2013, 145: 670-675.
  9. Lau AJ, Yang G, Yap CW, Chang TKH. Selective agonism of human pregnane X receptor by individual ginkgolides. Drug Metabolism and Disposition, 2012, 40: 1113-1121.
  10. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor. Drug Metabolism and Disposition, 2012, 40: 178-186.
  11. Lau AJ, Yang G, Chang TKH. Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: Functional analysis of the SV23, SV24, and SV25 splice variants. Journal of Pharmacology and Experimental Therapeutics, 2011, 339: 704-715.
  12. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. Journal of Pharmacology and Experimental Therapeutics, 2011, 336: 816-826.
  13. Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TKH. Human pregnane X receptor agonism by Ginkgo biloba extract: Assessment of the role of individual ginkgolides. Journal of Pharmacology and Experimental Therapeutics, 2010, 335: 771-780.
  14. Lau AJ and Chang TKH. Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: Effect of terpene trilactones and flavonols. Drug Metabolism and Disposition, 2009, 37: 1931-1937.