BSc (Pharm) (Hons), University of Singapore
PhD, National University of Singapore
Department of Pharmacy, National University of Singapore
18 Science Drive 4, Singapore 117543
Tel: +65 6516 2654
Fax: +65 6779 1554
Teaching Activities in NUS
I am involved in the teaching of three modules : a general education module (GEK 2506) Drugs and Society and two medicinal chemistry modules, Principles of Medicinal Chemistry (PR 3101) and Advanced Topics in Medicinal Chemistry (PR 5212).
My research interests are in the area of designing and synthesizing novel compounds with the aim of optimizing biological activity and understanding their modes of action by structure-activity relationship studies, biochemical and pharmacological approaches. Among other factors, our design approaches are made with “drug-like” properties in mind. These are the intrinsic properties of permeability, solubility and microsomal stability which are often the final arbitrators of whether a chemical entity progresses down the developmental pipeline or is sidelined. Such considerations are particularly important in tuberculosis (TB) drug research for many reasons. These include the challenge of delivering chemical entities across the almost impermeable cell envelope of mycobacteria, the persistence of bacteria within protective granulomas and pharmacokinetic (PK) issues related to multidrug therapy. Our current focus is on cationic amphiphilic indoles which selectively target the mycobacterial membrane.