Conferences

  1. A Karkhanis, NDT Tram and ECY Chan. Perturbation of arachidonic acid metabolism by antiarrhythmic drugs: Implications in cardiac safety? AAPS-NUS 12th PharmSci@Asia Symposium, July 4-5, Chinese University of Hong Kong, China. Best Poster Presentation Award NEW!
  2. EJY Cheong, JJN Goh, Y Hong,  ECY Chan. Co-administration of amiodarone and rivaroxaban: A PBPK guided approach for prospective dose adjustments in the presence of complex drug-drug interactions. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany. Invited Podium Presentation cum Predoctoral Poster Award Finalist 
  3. SH Lee, V Limviphuvadh, M Maurer-Stroh, HK Chin, SK Ng,  ECY Chan. Unraveling the interindividual variation of urinary hippurate: in silico investigation of single nucleotide polymorphisms along the phenylproionate-hippurate axis. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany.
  4. JCY Chan, F Lin, H Fan, ECY Chan. Electrophilic reactivity of and human serum albumin conjugation by para-phenylenediamine and its oxidized products: In vitro and in silico evaluation. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany.
  5. JCY Chan, DYQ Kioh, CSM Goh, J Common, ECY Chan. Estimation of intradermal fraction of abiotically oxidizable para-phenylenediamine using metabolically active keratinocytes. 14th European ISSX Meeting 2017, June 26-29, Cologne, Germany.
  6. ECY Chan, JCY Chan. Proteo-metabolomics in elucidating mechanisms of acetaminophen toxicity. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea. Drug Metabolism and Pharmacokinetics 2017, (32) S12-S13 Suppl.
  7. JCY Chan, DYQ Kioh, GC Yap, BW Lee, ECY Chan. Targeted LC/MS-based quantitative profiling of 15 gut microbiome-derived short-chain fatty acids in infant and adult stool. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea.
  8. A Karkhanis, JWH Leow, YZ Khow, TY Ng, WW Teng, ECY Chan. Dronedarone inhibits CYP2J3 activity in H9c2 cardiomyocytes without mitochondrial toxicity. 11th International ISSX Meeting 2016, June 12-16, Busan, South Korea.
  9. A Karkhanis, HY Lam, G Venkatesan, CLL Chai, L Zhou, Y Hong, P Kojodjojo, ECY Chan. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Experimental Biology Meeting 2016, April 2-6, San Diego, USA.
  10. JCY Chan, ACK Soh, SK Koh, L Zhou, ECY Chan. Protein Glutathionylation: A New Dimension of Covalent Binding in Acetaminophen Toxicity. 20th North American Regional ISSX Meeting, October 18-22, Orlando, Florida, USA. Drug Metabolism Reviews 2016, (48) 116-117, Suppl 1.
  11. JCY Chan, PXL Teng, WJ Ng, PR Lim, ZT Su, KP Kumar, E Browne, PS Ong, ECY Chan. Combinatorial Lapatinib and Endoxifen Exhibits Pharmacodynamic and Pharmacokinetic Synergism in Tamoxifen-Resistant Breast Cancer. 20th North American Regional ISSX Meeting, October 18-22, Orlando, Florida, USA. Drug Metabolism Reviews 2016, (48) 21-22, Suppl 1. Third Prize Predoctoral Poster Award
  12. A Karkhanis, HY Lam, ECY Chan. Reversible inhibition and mechanism-based inactivation of human CYP2J2 by dronedarone and amiodarone. 13th European ISSX Meeting 2015, June 22-25, Glasgow, Scotland, United Kingdom.
  13. Y Hong, EJY Cheong, ECY Chan. Prediction of in vivo drug-drug interactions between dronedarone and rivaroxaban based on in vitro inhibition studies. 13th European ISSX Meeting 2015, June 22-25, Glasgow, Scotland, United Kingdom.
  14. LC Phua, CH Wilder-Smith, RK Wong, G Venkatesan, ECY Chan. In Combat Soldiers Resting Urinary Metabotypes Correlate With the Development of Gastrointestinal Symptoms During Stress. Digestive Disease Week 2015, May 16-19, Washington, DC, USA. Gastroenterology 2015, 148 (4), Suppl 1, S-21.
  15. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian, ECY Chan. Combat-training stress mediates metabotypic changes associated with gastrointestinal symptoms and altered intestinal permeability. 22nd United European Gastroenterology Week 2014, October 18-22, Vienna, Austria. Gastroenterology2014, 146 (5), Suppl 1, S-533–S-534 Poster in the Spotlight
  16. LY Yip, SH Lee, YS Hong, JMX Chan, EY Koh, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. The gut microbiome: Implications in tacrine-induced transaminitis. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 36-37, Suppl 1. First Prize Predoctoral Poster Award cum Podium Presentation Faculty of Science Research News
  17. Y Hong, RH Yeo, ECY Chan. Inhibitory Effects of Dronedarone and its N-desbutyl metabolite on Human CYP3A4 and CYP3A5 Activities. 19th North American ISSX and 29th JSSX 2014, October 19-23, San Francisco, CA, USA. Drug Metabolism Reviews 2015 (47) 134-135, Suppl 1.
  18. JCY Chan, DYM Choo, ECY Chan. Impact of CYP3A5 genetic polymorphism on mechanism-based inactivation by lapatinib. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews (47) 173, Suppl 1. Invited Podium Presentation for “Drug-drug Interactions: Novel Mechanisms and Advances in Prediction” session Faculty of Science Research News
  19. JCY Chan, ACK Soh, SK Koh, L Zhou, ECY Chan. Protein glutathionylation: the hidden hand in acetaminophen toxicity. 19thNorth American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 36, Suppl 1. Second Prize Predoctoral Poster Award cum Podium Presentation
  20. JCY Chan, P Lim, PS Ong, ECY Chan. A metabolism-driven combinatorial approach to overcome ER/HER2 crosstalk in breast cancer. 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014, October 19-23, San Francisco, California, USA. Drug Metabolism Reviews 2015, (47) 110, Suppl 1.
  21. LC Phua, YM Tan, RK Wong, X Li, CH Wilder-Smith, ECY Chan. Noninvasive urinary metabonomic diagnosis of inflammatory bowel disease using gas chromatography/mass spectrometry. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-429
  22. LC Phua, CH Wilder-Smith, YM Tan, T Gopalakrishnan, RK Wong, X Li, ME Kan, J Lu, A Keshavarzian, ECY Chan. Combat-training stress mediates metabotypic changes associated with gastrointestinal symptoms and altered intestinal permeability. Digestive Diseases Week 2014, June 3-6, Chicago, IL, USA. Gastroenterology 2014, 146 (5), Suppl 1, S-533–S-534.
  23. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee, ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 147 (45), Suppl 1.
  24. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne, ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 174 (45), Suppl 1.
  25. CY Chan, BL Nunn, DR Goodlett, SK Koh, L Zhou, ECY Chan. GluICAT: A novel liquid chromatography-mass spectrometry-based method for profiling protein glutathionylation. 10th International ISSX Meeting 2013, September 29-October 3, Toronto, Canada. Drug Metabolism Reviews 2014, 26-27 (45), Suppl 1. Predoctoral Poster Award Finalist
  26. HT Chng, YY Dan, SJ Lin, S Aparna, HK Ho, ECY Chan. Characterization of the drug disposition transcript profile of hepatocyte-like cells derived from human fetal liver multipotent progenitor cells and human amniotic epithelial cells. ADME & Predictive Toxicology 2013, 11-12 April, Barcelona, Spain. Poster Award
  27. Y Hong, YMF Chia, ECY Chan. Interaction of Dronedarone with Human CYP450 Enzymes: Metabolism and Inhibition. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.
  28. YM Tan, HT Chng, P Chuah, SH Lam, ECY Chan. Zebrafish as an in vivo High-throughput Screening Model for CYP3A4 Induction. ADME & Predictive Toxicology 2013, April 11-12, Barcelona, Spain.
  29. P Bahety, YM Tan, Y Hong, ECY Chan and PLR Ee. Gas Chromatography/Time-Of-Flight Mass Spectrometry Metabotyping of Docosahexaenoic Acid-Treated Alzheimer’s Disease Cell Model. Globalization of Pharmaceutics Education Network Meeting (GPEN) 2012, November 28 – December 1, Melbourne, Australia. Biota and Teikoku Seiyaku Co. Ltd Housing Grant and Travel Grant Award
  30. HT Chng, RFS Lee, SH Lam, Z Gong, HK Ho and ECY Chan. Zebrafish: an in vivo high-throughput screening model for CYP3A4 induction and inhibition. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands. Predoctoral Poster Award Finalist
  31. LC Phua, PK Koh, PY Cheah, LY Yip, A Sampathkumar, YM Tan, HK Ho and ECY Chan. Global gas chromatography/time-of-flight mass spectrometry (GC/TOFMS)-based metabotyping of lyophilized human feces. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  32. LY Yip,CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee, ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  33. HT Chng, YY Dan, SJ Lin, HK Ho and ECY Chan. Basal gene expression of drug metabolizing enzymes, transporters and nuclear receptors in hepatocyte-like cells derived from human fetal liver multipotent progenitor cells. 19th MDO Meeting and 12th European ISSX Meeting 2012, June 17-21, the Netherlands.
  34. HT Chng, HK Ho, SH Lam and ECY Chan. Isolation of zebrafish (Danio rerio) liver microsomes: protocol and considerations. 9th International ISSX Meeting 2010, September 4-8, Istanbul. Drug Metabolism Reviews 42-S1 (2010) 190–191.
  35. ECY Chan, JW Oh, LS New and HK Ho. Investigating the molecular mechanism of lapatinib-induced liver toxicity”. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-S2 (2009) 89.
  36. LS New, CW Yap, LT Goh and ECY Chan. Pharmaceutical metabolite profiling using quadrupole/ion mobility spectrometry/time-of-flight mass spectrometry. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 53.
  37. X Ma and ECY Chan. Fluorescence-based screening of pharmaceutical reactive metabolites using glutathione immobilized 96-well microsomal assay. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26-27. First Prize Postdoctoral Fellow Category
  38. S Saha, LS New, HK Ho, WK Chui and ECY Chan. Investigation of the role of thiazolidinedione of troglitazone in inducing hepatotoxicity in humans. ISSX 3rd Regional Asia Pacific Meeting 2009, May 09-12, Bangkok. Drug Metabolism Reviews 41-s2 (2009) 26.
  39. KK Pasikanti, J Norasmara, R Mahendran, K Esuvaranathan, PC Ho and ECY Chan. Extracellular metabonomics of human non-tumorigenic and tumorigenic uroepithelial cells. Metabolomics 2008, September 2-6, Boston.
  1. JY Woon, JCY Chan, DYQ Kioh, BW Lee and ECY Chan. Global metabonomics of infant stool in childhood eczema. Pharmacy Research Awareness Symposium 2017, April 5, Singapore. First Prize Poster Award (PK Domain Category)
  2. RH Ho, JCY Chan, DYQ Kioh, BW Lee, H Fan and ECY Chan. Investigation of the Chemical Interactions Between Short Chain Fatty Acids and Human Histone Deacetylases. Pharmacy Research Awareness Symposium 2017, April 5, Singapore. Second Prize Poster Award (PK Domain Category)
  3. A Karkhanis, NDT Tram and ECY Chan. Perturbation of arachidonic acid metabolism by antiarrhythmic drugs: Implications in cardiac safety? Pharmacy Research Awareness Symposium 2017, March 28, Singapore. Best Poster Award (PhD Category)
  4. P Lim, JCY Chan, PS Ong and ECY Chan. A Combinatorial Approach to Targeting Molecularly Diverse Breast Cancer Phenotypes. 25th Singapore Pharmacy Congress 2015, September 12-13, Singapore. First Prize Poster Award (Pharmaceutical Sciences) 
  5. JCY Chan, WJ Ng, PXL Teng, ZT Su, KP Kumar, ER Browne, PR Lim, PS Ong and ECY Chan. Leveraging Pharmacodynamic and Pharmacokinetic Synergism in the Treatment of Breast Cancer. 10th PharmSci@ Asia Symposium 2015, April 09, Singapore. Best Poster Presentation Award
  6. A Karkhanis, HY Lam and ECY Chan. Inhibitory Effect of Dronedarone and Amiodarone on Human Cardiac CYP2J2. Yong Loo Lin School of Medicine 5th Annual Graduate Scientific Congress (AGSC) 2015, January 27, Singapore.
  7. LY Yip, HC Ku, CC Aw, WS Chen, ER Browne, R Mahendran, YK Lee and ECY Chan. Investigation of host-gut microbiome interaction in tacrine-dosed Lister-hooded rats through fecal metabolic profiling. Annual Pharmacy Research Symposium 2014, April 9, Singapore. First Prize for Postgraduate Abstract Presentation Contest (Pharmacokinetics/Toxicokinetics Category) 
  8. LY Yip, JMX Chan, A Sampathkumar, R Mahendran, YK Lee, CC Aw, WS Chen, ER Browne and ECY Chan. Fecal microbiome profiling reveals association of β-glucuronidase producing bacteria with susceptibility to tacrine-induced hepatotoxicity. Yong Loo Lin School of Medicine 4th Annual Graduate Scientific Congress (AGSC) 2014, March 11, Singapore. Best Poster Presentation Award
  9. LY Yip, CC Aw, WS Chen, LS New, YM Tan, ER Browne, R Mahendran, YK Lee and ECY Chan. Exploring the Interaction of Host and Gut Microbiome in the Toxicokinetics of Tacrine. Yong Loo Lin School of Medicine 3rd Annual Graduate Scientific Congress (AGSC) 2013, January 30, Singapore. Best Poster Presentation Award
  10. ECY Chan, LS New, KK Pasikanti, PW Goh, LY Yip, CW Goh, CC Aw and ER Browne. Toxicometabonomics phenotyping of tacrine-induced liver transaminitis.Singapore Society for Mass Spectrometry Conference 2011, September 22-23, Singapore. First Prize SSMS-Agilent 2011 Poster Award
  11. JW Oh, LS New, HK Ho and ECY Chan. Investigating the molecular mechanism of lapatinib-induced liver toxicity. Singapore Pharmacy Congress 2009, July 25-26, Singapore. First Prize Poster Category
  1. MERLION Metabolomics Workshop Singapore 2014, 19-21 November 2014, organized by NUS Environmental Research Institute, Metabohub, La France à Singapour and Institut Français de Singapour
  2. Educating Pharmacists (Asia) Symposium 2010, 15-16 April 2010, organized by the Department of Pharmacy, National University of Singapore.
  3. Asian Symposium on ADMET Profiling for Drug Discovery: Metabolism and Drug Safety, 15-16 September 2009, organized by the Department of Pharmacy, National University of Singapore.