Our Group

A/Prof Giorgia Pistorin
Group Advisor
phapg@nus.edu.sg

Giorgia Pastorin received her MSc degree in Pharmaceutical Chemistry and Technology in 2000 and her Ph.D. in 2004 from the University of Trieste (Italy), working on adenosine receptors’ antagonists. She spent 2 years as a postDoc at CNRS in Strasbourg (France) where she acquired some skills in drug delivery. She joined the National University of Singapore in June 2006, as Assistant Professor in the Department of Pharmacy-Faculty of Science. She was promoted to Associate Professor in 2011, Assistant Head in 2014 and she is currently Deputy Head (Research)in the same Department.

Her research interests focus on Drug Delivery, through the exploitation of synthetic and cell-derived nanoparticles, for a variety of potential therapeutic applications. She also has a project in Medicinal Chemistry, aimed at  the identification of dual targeting ligands for the treatment of Parkinson’s disease.For the work performed by her BioNanoTechnology group in NUS , she recently received the Young Scientist Award (2015).

She is the Editor of two books related to drug delivery and author in more than 100 articles on internationally peer-reviewed journals.

Research interests:

Nano-Bio-Technologies:

  • Production, characterization & exploitation of Cell-derived Nanovesicles (CDNs) as novel biocompatible delivery systems
  • Targeted drug delivery, through strategic functionalizations of nanomaterials.
  • Transdermal (vaccine) delivery through aligned nano-needles systems.
  • Toxicological evaluation of drug delivery systems for biomedical applications.

Medicinal Chemistry:

  • Novel multi-targeting chemical entities for the treatment of Parkinson's disease.
  • Publication list: please see attachment. I would prefer if the most recent papers are up and the older are down, so that it is easier to visualize the research direction towards exosomes.

Dr Czarny Bertrand Marcel Stanisl
Senior Research Fellow
phacbms@nus.edu.sg

My research interests lies in the fields of nanomedicine and toxicology in several disease models, with special focus for the development of preclinical studies on inflammatory disease such as cardiovascular disease, eye inflammation and Crohn’s disease. The key advantage in my research is that I utilize Good Manufacturing Practice (GMP) formulations, which enable a faster translation into clinically relevant outcomes.

Dr Gopalakrishnan Venkatesan
Research Fellow
phagove@nus.edu.sg

Dr Gopalakrishnan Venkatesan received his PhD from Dept of Pharmacy, National University of Singapore in the year 2013. After the Graduation, he has worked as Research Fellow in the Dept of Pharmacy, National University of Singapore from 2014-2016. His past work was focused on labelled drug synthesis, metabolism, pharmacokinetics and Proteomics research. Currently, he has undertaken the project “the development of nontoxic non allergic polymeric chemical for hair dye preparation” involves the Skin permeation study, Metabolism, Pharmacokinetics.

Yang Zhi
PhD Student
a0109716@u.nus.edu

My research topic is synthesis and characterization of mitochondria-targeting platinum (IV) prodrugs. Mitochondrion plays an important role in ATP production and providing energy for cellular metabolism. In addition, it has its own DNA but lack of repair mechanisms. Therefore, we expect our mitochondria-targeting Pt (IV) prodrugs can firstly target mitochondria by the static electric interactions between positively charged triphenylphosphonium (TPP) and negatively charged mitochondrial membranes, and then the cisplatin scaffold can bind to mitochondrial DNA and dichloroacetic acid (DCA) can take effect at mitochondria sites to induce mitochondrial dysfunction, which eventually lead to cell death.

Goh Wei Jiang
PhD Student
A0046281@u.nus.edu
wjgoh@u.nus.edu

GOH Wei Jiang graduated from National University of Singapore (NUS) with a bachelor in Pharmacy and practiced at Singapore General Hospital as a registered pharmacist before pursuing his graduate studies in the NUS PhD-MBA program. His research interests include formulation work, nanoparticles and drug delivery, with special emphasis on novel BioNanoTechnology platforms such as Cell Derived Nanovesicles (CDNs) and EXOPLEXs. Wei Jiang has played an pivotal role in the conception, development and eventual commercialization of a new proprietary Drug Delivery System termed EXOPLEXs in the BNT Research Group. Wei Jiang was also instrumental in the conception and development of proniosomal gels for transdermal delivery of natural products in the relief of arthritic pain.

Tan Boon Wu Aaron
PhD Student
a0109716@u.nus.edu

Tan Boon Wu Aaron received his B.Appl.Sc with Second Upper Class Honours in Drug Chemistry, in Applied Chemistry in 2014 from the National University of Singapore (Singapore), working on the enantioselective hydrogenation of α-phenylcinnamic acid as his final year project under A/P Stephan Jaenicke. He received scholarship for his PhD studies from NUS School of Integrative Sciences and Engineering (NGS, National University of Singapore) and joined this lab in 2014.

His research interests focus on development of dual-ligand targeting NCEs against adenosine hA2A and dopamine hD2 receptors for PD therapy.

Lim Jieling
PhD Student
lim.jieling@u.nus.edu

Lim Jieling’s research focus is on chemotherapy for multidrug-resistant TB tuberculosis (TB). Existing TB compounds can be revisited to tackle their limitations. One possible method is through the use of drug delivery systems (DDS), namely liposomes and a novel system – bacterial ghosts (BGs).  Loaded BGs can launch a two-pronged attack on intracellular mycobacteria upon macrophage uptake: the combined effect from the anti-mycobacterial activity of the encapsulated drug and the BG-induced production of reactive intermediates may result in greater bactericidal activity. The objective of this project is to determine the effectiveness of loaded DDS upon pharmaceutical characterization and evaluation of their in vitro and ex vivo killing efficacy compared to free drug.

Zou Shui
PhD Student
zoushui@u.nus.edu

Zou Shui obtained her bachelor degree (Honours) in Chemistry (2014) from National University of Singapore (NUS). She is currently pursuing her PhD in Department of Pharmacy, NUS. Her research interest focuses on the delivery of microRNAs using cell-derived delivery platform for the treatment of obesity as well as using novel strategies to coax white fat cells to turn into the more thermogenic brown-like fat cells.

Lee Choon Keong
PhD Student
phalck@nus.edu.sg

LEE Choon Keong graduated from National Technological University of Singapore, and worked at Giorgia Lab Group as a Research Assistant before starting his PhD studies. His research interests include working and further optimizing on the in-house developed EXOPLEXs, a novel Drug Delivery System as well as developing novel transdermal delivery systems for relief of arthritic pain using natural products.



Last updated on 16 October 2016