Publications and Patents

Books/Monographs

Carbon Nanotubes:
From Bench Chemistry to
Promising Biomedical Applications, Singapore

PASTORIN*, G, M van der Merwe, G Spalluto, T Da Ros, T R Nayak, J Li, V S Makam, S L Cheong, G Venkatesan, Y Ren and Cécilia Ménard-Moyon, Carbon Nanotubes: from bench Chemistry to promising Biomedical Applications, Singapore: Pan Standford, 2010. 333 pp.

Controlled Release Systems:
Advances in Nanobottles and Active Particles

Edited by - Alex van Herk, Jacqueline Forcada, Giorgia Pastorin: Pan Stanford, 31 Dec 2015

Publications



2016

Chow, Mun Juinn, Babak, Maria, Wong, Daniel Yuan Qiang, Pastorin, Giorgia, Gaiddon, Christian, Ang, Wee Han*. Structural Determinants of p53-Independence in Anticancer Ruthenium-Arene Schiff-base Complexes. Molecular Pharmaceutics, 2016, in Press.

Sara Redenti, Antonella Ciancetta, Giorgia Pastorin, Barbara Cacciari, Stefano Moro, Giampiero Spalluto, Stephanie Federico. Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists. Current Topics in Medicinal Chemistry. Accepted

Mun Juinn Chow, Cynthia Licona, Giorgia Pastorin, Georg Mellitzer, Wee Han Ang* and Christian Gaiddon*. Structural tuning of organoruthenium compounds allows oxidative switching to control ER stress pathways and bypass multidrug resistance. Chemical Science, 2016, in Press.

Hao Wang, Zhuolin Xiang, Pastorin Giorgia, Xiaojing Mu, Ya Yang, Zhong Lin Wang, and Chengkuo Lee*. Triboelectric liquid volume sensor for self-powered lab-on-chip applications, Nano Energy, 2016, in Press.

Hao Wang, Giorgia Pastorin and Chengkuo Lee. Toward Self-powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery. Adv. Sci. (Wiley), In Press.

Stephanie Federico, Antonella Ciancetta, Nicola Porta, Sara Redenti, Giorgia Pastorin, Barbara Cacciari, Karl Norbert Klotz, Stefano Moro, Giampiero Spalluto. 5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors. European Journal of Medicinal Chemistry 2016, 108, 529-541.

Siew lee Cheong, Stephanie Federico, Aaron Boon Wu Tan, Giampiero Spalluto, Giorgia Pastorin. A3 Adenosine Receptor Ligands in the Treatment of Inflammation and Cancer. Pharmaceutical Formulation and Medicinal Chemistry: Mechanisms, Developments and Treatments. Bruce Moore Editor, 2015, Nova Publisher, New York.

Panczyk, Tomasz; Konczak, Lukasz; Narkiewicz-Michalek, Jolanta; Pastorin, Giorgia. Corking and Uncorking Carbon Nanotubes By Metal Nanoparticles Bearing pH Cleavable Hydrazone Linkers. Theoretical Analysis Based On Molecular Dynamics Simulations. The Journal of Physical Chemistry Part C, 2016, 120(1), 639-649.


2015

Jian Li, Sia Lee Yoong, Wei Jiang Goh, Bertrand Marcel Stanisl Czarny, Zhi Yang, Kingshuk Poddar, Michal Dykas, Abhijeet Patra, Thirumalai Venkatesan, Tomasz Panczyk, Chengkuo Lee*, Giorgia Pastorin*. In vitro Controlled Release of Cisplatin from Gold-Carbon Nanobottles via Cleavable Linkages. International Journal of Nanomedicine, 2015, 10, 7425–7441.

Chunyan Zhao, Henrik Andersen, Barbaros Ozyilmaz, Sundara Ramaprabhu, Giorgia Pastorin, Han Kiat Ho. Spontaneous and specific myogenic differentiation of human mesenchymal stem cells on polyethylene glycol-linked multi-walled carbon nanotube films for skeletal muscle engineering. Nanoscale, 2015, 7, 18239-18249.

Bi, Xinyan; Adriani, Giulia; Xu, Yang; Chakrabortty, Sabyasachi; Pastorin, Giorgia; Ho, Han Kiat; Ang, Wee Han; Chan, Yinthai. Gene Detection in Complex Biological Media using Semiconductor Nanorods within an Integrated Microfluidic Device. Analytical Chemistry, 2015, 87 (20), 10292–10298.

Sia Lee Yoong, Wei Liang Lau, Ang Yu Liu, D’Arcy Prendergast, Han Kiat Ho, Victor Chun Kong Yu, Chengkuo Lee, Wee Han Ang,* and Giorgia Pastorin*. Mitochondria-acting Hexokinase II Peptide Carried by Short-length Carbon Nanotubes with Increased Cellular Uptake, Endosomal Evasion, and Enhanced Bioactivity Against Cancer Cells. Nanoscale, 2015, 7, 13907 – 13917.

Zhuolin Xiang, Hao Wang, Giorgia Pastorin and Chengkuo Lee*. Development of A Flexible and Disposable Microneedle-Fluidic-System with Finger-Driven Drug Loading and Delivery Functions for Local Inflammation Treatment. JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, 2015, 24(3), 565-574.

Sergey Shityakov*, Ellaine Salvador, Giorgia Pastorin, Carola Förster. Blood–brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate. International Journal of Nanomedicine, 2015, 10, 1703–1713.

Laura Muzi, Cécilia Ménard-Moyon, Julie Russier, Jian Li, Chee Fei Chin, Wee Han Ang, Giorgia Pastorin*, Gianfranco Risuleo, Alberto Bianco*. Diameter-dependent release of a cisplatin pro-drug from small and large functionalized carbon nanotubes. Nanoscale, 2015, 7(12), 5383-5394.

Chow, Mun Juinn; Licona, Cynthia; Wong, Daniel Yuan Qiang; Pastorin G, Gaiddon C., Ang Wee Han. Discovery and Investigation of Anticancer Ruthenium-Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly. Journal of Medicinal Chemistry, 2014, 57 (14), 6043-6059.

G. Venkatesan, P. Paira, S.L. Cheong, S. Federico*, K.N. Klotz, G. Spalluto*, G. Pastorin*. A facile and novel synthesis of N2-, C6-substituted pyrazolo[3,4-d]pyrimidine-4 carboxylate derivatives as adenosine receptor antagonists. European Journal of Medicinal Chemistry, 2015, 92, 784-798.

Zhuolin Xiang, Hao Wang, Suresh Kanna Murugappan, Shih-Cheng Yen, Giorgia Pastorin* and Chengkuo Lee*. Dense vertical SU-8 microneedles drawn from a heated mold with precisely controlled volume. J. Micromech. Microeng. 2015, 25, 025013 (10 pp).


2014

Hao Wang, Zhuolin Xiang, Chih-Fan Hu, Giorgia Pastorin, Weileun Fang, and Chengkuo Lee. Microneedle Array Integrated with CNT Nanofilters for Controlled and Selective Drug Delivery. IEEE Journal of Microelectromechanical Systems. 2014, 23(5), 1036-1044. (October)

Siew Lee Cheong, Choon-Peng Chng*, Vamsi Krishna Kosaraju, Feng Xue, Stephanie Federico, Giampiero Spalluto, Chun Wei Yap and Giorgia Pastorin*. Modeling of antagonist binding site through a hA3 ‘hybrid’ homology model for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Journal of Computer-Aided Molecular Design. 2013, under revision.

Siew Lee Cheong, Choon-Peng Chng, Vamsi Krishna Kosaraju, Feng Xue, Stephanie Federico, Giampiero Spalluto, Chun Wei Yap,* and Giorgia Pastorin*. A new series of 2-Aryl-Pyrazolo-Triazolo-Pyrimidines as potent hA3 Adenosine Receptor Antagonists: QSAR analysis and CoMFA-guided Modeling of Antagonist Binding Site through a hA3 ‘hybrid’ Homology Model. European Journal of Medicinal Chemistry. Under revision.

Prachi Singh, Ganesh R. Kokil, Karnaker R. Tupally, Kingshuk Poddar, Aaron Tan, Venky venkatesan, Harendra Parekh* Giorgia Pastorin* Therapeutic Perspective in Type-1 Diabetes. 2015, Springer Briefs in Applied Sciences and Technology.

Stephanie Federico, Antonella Ciancetta, Nicola Porta, Sara Redenti, Giorgia Pastorin, Barbara Cacciari, Karl Norbert Klotz, Stefano Moro,* and Giampiero Spalluto*. Scaffold Decoration at Positions 5 and 8 of 1,2,4-Triazolo[1,5-c]Pyrimidines to Explore the Antagonist Profiling on Adenosine Receptors: A Preliminary SAR Study. Journal of Medicinal Chemistry, 2014, 57(14), 6210-6225.

Chee Fei Chin, Siew Qi Yap, Jian Li, Giorgia Pastorin* and Wee Han Ang*. Ratiometric Delivery of Cisplatin and Doxorubicin using Tumour-Targeting Carbon-Nanotubes Entrapping Platinum(IV) Prodrugs. Chemical Science, 2014, 5, 2265-2270.

Tomasz Panczyk*, Tatiana Da Ros, Giorgia Pastorin, Anna Jagusiak, Jolanta Narkiewicz-Michalek. Role of Intermolecular Interactions in Assemblies of Nanocontainers Composed of Carbon Nanotubes and Magnetic Nanoparticles. A Molecular Dynamics Study. The Journal of Physical chemistry, Part C, 2014, 118 (2), 1353–1363.

Jian Li , Aakansha Pant, Chee Fei Chin, Wee Han Ang*, Cécilia MENARD-MOYON, Tapas R. Nayak, Dan Gibson, Sundara Ramaprabhu, Tomasz Panczyk, Alberto BIANCO*, and Giorgia PASTORIN*. In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes. Nanomedicine, 2014, 10(7), 1465–1475.

Sia Lee Yoong, Bin Sheng Wong, Qi Lin Zhou, Chee Fei Chin, Jian Li, Thirumalai Venky Venkatesan, Han Kiat Ho, Victor Chun Kong Yu, Wee Han Ang*, Giorgia Pastorin*. Enhanced Cytotoxicity to Cancer Cells by Mitochondria-targeting MWCNTs Containing Platinum(IV) Prodrug of Cisplatin. Biomaterials, 2014, 35(2), 748–759.


2013

Chunyan Zhao, Aaron Tan, Giorgia Pastorin*, Han Kiat Ho*. Nanomaterial scaffolds for stem cell proliferation and differentiation in tissue engineering. Biotechnology Advances, 2013, 31(5), 654–668.

Hao Wang, Zhuolin Xiang, Chih-Fan Hu, Aakanksha Pant, Weileun Fang, Sylvie Alonso, Giorgia Pastorin* and Chengkuo Lee*. Development of Stretchable Membrane Based Nanofilters Using Patterned Array of Vertically Grown Carbon Nanotubes. Nanoscale, 2013, 5, 8488–8493

Bin Sheng WONG*, Sia Lee YOONG, Anna JAGUSIAK, Tomasz PANCZYK, Han Kiat HO, Wee Han ANG, Giorgia PASTORIN*. Carbon Nanotubes For Delivery of Small Molecule Drugs. Advanced Drug Delivery Reviews, 2013, 65, 1964-2015.

Panczyk, Tomasz; Jagusiak, Anna; Pastorin, Giorgia; Ang, Wee Han; Narkiewicz-Michalek, Jolanta. Molecular Dynamics Study of Cisplatin Release From Carbon Nanotubes Capped By Magnetic Nanoparticles. The Journal of Physical Chemistry. Part C: Energy Conversion and Storage, Optical and Electronic Devices, Interfaces, Nanomaterials, and Hard Matter. Section: C: Physical Processes in Nanomaterials and Nanostructures. 2013, 117 (33), 17327–17336.

Jan Gruber, Sheng Fong, Ce-Belle Chen, Sialee Yoong, Giorgia Pastorin, Sebastian Schaffer, Irwin Cheah, Barry Halliwell*. Mitochondria-targeted Antioxidants and Metabolic Modulators as Pharmacological Interventions to slow Ageing. Biotechnology Advances 2013, 31(5):563-92.

Siew Lee Cheong, Stephanie Federico, Gopalakrishnan Venkatesan, Alexander Laurence Mandel, Yi-Ming Shao, Stefano Moro, Giampiero Spalluto, Giorgia Pastorin*. Human A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry and in silico approaches. Medicinal Research Reviews, 2013, 33(2), 235-335.

Zhuolin Xiang, Wang Hao, Aakanksha Pant, Giorgia Pastorin*, Chengkuo Lee*. Development of vertical SU-8 microneedles for transdermal drug delivery by double drawing lithography technology. Biomicrofluidics, 2013, 7 (6), 6501.

Zhuolin Xiang, Wang Hao, Aakanksha Pant, Giorgia Pastorin*, Chengkuo Lee*. Development of Vertical SU-8 Microtubes Integrated with Dissolvable Tips for Transdermal Drug Delivery. Biomicrofluidics, 2013, 7, 026502.

Xiao Chen, Ce-Belle Chen, Chammika N. B. Udalagama, Minqin Ren, Kah Ee Fong, Lin Yue Lanry Yung, Pastorin Giorgia, Andrew Anthony Bettiol, Frank Watt. High-Resolution 3D Imaging and Quantification of Gold Nanoparticles in a Whole Cell Using Scanning Transmission Ion Microscopy. Biophysical Journal, 2013, 104, 1419-1425.

Jun Hu, Yuancai Dong, Giorgia Pastorin*, Wai Kiong Ng*, Reginald B. H. Tan. Spherical agglomerates of pure drug nanoparticles for improved pulmonary delivery in dry powder inhalers. Journal of Nanoparticle Research, 2013, 15, 1560.

Priyankar Paira, Chow Mun Juinn, Gopalakrishnan Venkatesan, Vamsi Krishna Kosaraju, Siew Lee Cheong, Karl-Norbert Klotz, Wee Han Ang*, Giorgia Pastorin*. Organoruthenium Antagonists of Human A3 Adenosine Receptors. Chemistry: a european journal, 2013, 19(25), 8321-8330.

Pastorin G. Carbon Nanotubes: From Bench Chemistry to Promising Biomedical Applications. Singapore: Pan Stanford publishing Pte Ltd.; 2010.


2012

Tapas R. Nayak and Giorgia Pastorin*. Nano-Carbon-Based Systems for the Delivery of Bioactive Agents: Pros and Cons. Chapter Nineteen. Nanopharmaceutics: The Potential Application of Nanomaterials. World Scientific publishing: August 2012. Pages: 535-569.

Jian Li, Siew Qi Yap, Sia Lee Yoong, Tapas Ranjan Nayak, Gary Wiratama Chandra, Wee Han Ang, Tomasz Panczyk, Sundara Ramaprabhu, Sandeep Kumar Vashist, Fwu-Shan Sheu, Aaron Tan, Giorgia Pastorin*. Carbon nanotube bottles for incorporation, release and enhanced cytotoxic effect of Cisplatin. Carbon, 2012, 50(4), 1625–1634.

Stephanie Federico, Antonella Ciancetta, Davide Sabbadin, Silvia Paoletta, Giorgia Pastorin, Barbara Cacciari, Karl Norbert Klotz, Stefano Moro and Giampiero Spalluto. Exploring the Directionality of 5-Substitutions in a New Series of 5-Alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a Strategy to Design Novel Human A3 Adenosine Receptor Antagonists. Journal of Medicinal Chemistry, 2012, 55, 9654−9668.

Tan A, Madani SY, Rajadas J, Pastorin G, Seifalian AM. Synergistic photothermal ablative effects of functionalizing carbon nanotubes with a POSS-PCU nanocomposite polymer. Journal of Nanobiotechnology. 2012,10(1), 34.

Wei Jiang Goh, Venkata S. Makam, Jun Hu, Lifeng Kang, Minrui Zheng, Sia Lee Yoong, Chammika N. B. Udalagama and Giorgia Pastorin*. Iron oxide filled magnetic carbon nanotube-enzyme conjugates for recycling of Amyloglucosidase: towards useful applications in biofuel production process. Langmuir, 2012, 28(49), 16864-16873.

Quan Tian, Winnie Wong, Yang Xu, Yinthai Chan, Han Kiat Ho, Giorgia Pastorin and Wee Han Ang*. Immobilisation of quantum dots by bio-orthogonal PCR amplification and labelling for direct gene detection and quantitation. Chem Commun 2012, 48, 5467-5469.

Jian Li, Siew Qi Yap, Chee Fei Chin, Quan Tian, Sia Lee Yoong, Giorgia Pastorin* and Wee Han Ang*. Platinum(IV) prodrugs entrapped within multiwalled carbon nanotubes: Selective release by chemical reduction and hydrophobicity reversal. Chemical Science, 2012, 3, 2083-2087.

Lara Lacerda, Julie Russier, Giorgia Pastorin, M. Antonia Herrero, Enrica Venturelli, Hélène Dumortier, Khuloud T. Al-Jamal, Maurizio Prato, Kostas Kostarelos*, Alberto Bianco*. Translocation mechanisms of chemically functionalised carbon nanotubes across plasma membranes. Biomaterials, 2012, 33 (11), 3334–3343.


2011

Tomasz Panczyk, Philip J. Camp, Giorgia Pastorin and Tomasz P. Warzocha. Computational study of some aspects of chemical optimisation of a functional magnetically triggered nanocontainer. Journal of Physical Chemistry C, 2011, 115 (39), 19074–19083.

Siew Lee Cheong, Anton V. Dolzhenko, Silva Paoletta, Evelyn Pei Rong Lee, Sonja Kachler, Stephanie Federico, Karl-Norbert Klotz, Anna V. Dolzhenko, Giampiero Spalluto*, Stefano Moro* and Giorgia Pastorin*.Does the combination of optimal substitutions at the C2, N5 and N8 positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A3 adenosine receptors? Bioorganic & Medicinal Chemistry, 2011, 19(20), 6120-6134.

Sandeep Kumar Vashist, Dan Zheng, Giorgia Pastorin, Khalid Al-Rubeaan, John H.T. Luong, Fwu-Shan Sheu*. Delivery of Drugs and Biomolecules using Carbon Nanotubes. Carbon, 2011, 49 (13), 4077-4097.

Aaron Tan, Lara Yildirimer, Jayakumar Rajadas, Hugo De La Peña, Giorgia Pastorin, Alexander Seifalian. Quantum dots and carbon nanotubes in oncology: a review on emerging theranostic applications in Nanomedicine. Nanomedicine, 2011, 6(6), 1101-1114.

Yupeng Ren*, Priyankar Paira, Tapas Ranjan Nayak, Wee Han Ang and Giorgia Pastorin*. Synthesis of Fullerene@Gold Core-Shell Nanostructure. Chemical Communications, 2011, 47 (27), 7710 – 7712.

Siew Lee Cheong*, Gopalakrishnan Venkatesan, Priyankar Paira, Ramasamy Jothibasu, Alexander Laurence Mandel, Stephanie Federico, Giampiero Spalluto,* and Giorgia Pastorin*. Pyrazolo derivatives as potent adenosine receptor antagonists: An overview on the structure-activity relationships. International Journal of Medicinal Chemistry, 2011, doi:10.1155/2011/480652.

Siew Lee Cheong, Stephanie Federico, Gopalakrishnan Venkatesan, Priyankar Paira, Yi-Ming Shao, Giampiero Spalluto, Chun Wei Yap*, Giorgia Pastorin*. Pharmacophore elucidation for a new series of 2-aryl-pyrazolo-triazolo-pyrimidines as potent human A3 adenosine receptor antagonists. Bioorganic & Medicinal Chemistry Letters, 2011, 21, 2898-2905.

Sanyog Jain, Ijeoma F. Uchegbu, Guru Betageri, and Giorgia Pastorin. Nanotechnology in Advanced Drug Delivery. Journal of Drug Delivery, 2011, 2011, Article ID 343082, doi:10.1155/2011/343082.

Li Jian, Tapas Ranjan Nayak, Gary Wiratama Chandra, Venkata Sudheer Makam, Sia Lee Yoong, Sundara Ramaprabhu and Giorgia Pastorin*. Incorporation and delivery of bioactive molecules from smart carbon nano-devices. Asian Chemistry Letters, 2011, 16 (1), 1-8.

Tapas Ranjan Nayak, Henrik Andersen, Venkata Sudheer Makam, Clement Khaw, Sukang Bae, Xiangfan Xu, Pui-Lai Rachel Ee, Jong Hyun Ahn, Byung Hee Hong, Giorgia Pastorin*, Barbaros Özyilmaz*. Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells. ACS Nano, 2011, 5(6), 4670–4678.

Federico, S, S Paoletta, S L CHEONG, G PASTORIN, B Cacciari, S Stragliotto, K N Klotz, J Siegel, Z G Gao, K Jacobson, S Moro* and G Spalluto*. "Synthesis and Biological Evaluation of a New Series of 1,2,4-Triazolo[1,5-a]-1,3,5-triazines". Journal of Medicinal Chemistry, 2011, 54 (3), pp 877–889.


2010

Tapas R. Nayak, Li Jian, Lee C. Phua, Han K. H o, Yupeng Ren and Giorgia Pastorin*. Thin films of functionalized Multiwalled carbon nanotubes as suitable scaffold materials for stem cells proliferation and bone formation. ACS Nano, 2010, 4(12), 7717-7725.

A.V. Dolzhenko, G.K. Tan, A.V. Dolzhenko, L.L. Koh and G. Pastorin. 8-Methyl-2-(4-trifluoromethylphenyl)-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine methanol disolvate. Acta Crystallographica Section E, (2010), 66(7), o1835-o1836.

Anna V. Dolzhenko, Anton V. Dolzhenko, Geok Kheng Tan, Lip Lin Koh and Giorgia Pastorin. N’-Acetyl-5-amino-1-methyl-1H-pyrazole-4-carbohydrazonamide dihydrate. Acta Crystallographica Section E: Structure. Reports Online (2010). E66, o1209–o1210.

Siew Lee Cheong, Anna Dolzhenko, Silvia Paoletta, Stephanie Federico, Barbara Cacciari, Anton Dolzhenko, Sonja Kachler, Karl-Norbert Klotz, Stefano Moro, Giampiero Spalluto, Giorgia Pastorin*. The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA3 adenosine receptor’s antagonists: New insights into Structure-affinity-relationship and Receptor-Antagonist Recognition. Journal of Medicinal Chemistry, 2010, 53(8), 3361-75.

Giorgia Pastorin, Stephanie Federico, Silvia Paoletta, Marta Corradino, Francesca Cateni, Barbara Cacciari, Karl-Norbert Klotz, Zhan-Guo Gao, Kenneth A. Jacobson, Giampiero Spalluto, Stefano Moro. Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand–receptor recognition process. Bioorganic & Medicinal Chemistry, 2010, 18, 2524-2536.

Giorgia Pastorin*, Tapas Ranjan Nayak and Yupeng Ren. Achievements and Challenges in the Delivery of bioactive molecules by Nano-Carbon-based Systems. International Journal of Biomedical Nanoscience and Nanotechnology (IJBNN), 2010, Vol. 1, Nos. 2/3/4, 267-289.

Anton Dolzhenko, Giorgia Pastorin, Anna Dolzhenko, Geok Kheng Tan and Lip Lin Koh. (4Z,6Z,12Z,14Z)- 2 , 1 0 - Dimethyl - 2, 8, 10, 16 - tetrahydrodipyrazolo [3, 4 - e: 3', 4' - l ][1,2,4,8,9,11]hexaazacyclotetradecine-4,12-diamine". Acta Crystallographica Section E. Structure Reports Online, 65, no. 7 (2009): o1578-o1579. (Denmark). Publication no. 0412955.


2009

Anton Dolzhenko, Giorgia Pastorin, Anna Dolzhenko, Geok Kheng Tan and Lip Lin Koh. 4-Hydrazino-1-methylpyrazolo[3,4-d]pyrimidine". Acta Crystallographica Section E: Structure. Reports Online, 65, no. 8 (2009): o1720-o1721. (Denmark). Publication no. 0414504.

Tapas R. Nayak, Pay Chin Leow, Pui-Lai Rachel Ee, Thevasahayam Arockiadoss, Sundara Ramaprabhu and Giorgia Pastorin*. Crucial Parameters responsible for Carbon Nanotubes toxicity. Current Nanoscience, 2010, 6(2), 141-154.

Anton V. Dolzhenko, Giorgia Pastorin, Anna V. Dolzhenko, Wai Keung Chui. A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters, 2009, 50, 5617-5621.

Wai-Keung Chui, Giorgia Pastorin, Aik-Jiang Lau. Learning the Use of Medicinal Herbs in Phytotherapy: A Tripartite Approach for Pharmacy Students. Pharmacy Education, 2009, 9 (1), 33-36.

Lisa Michielan, Chiara Bolcato, Stephanie Federico, Barbara Cacciari, Magdalena Bacilieri, Karl Norbet Klotz, Sonja Kachler, Giorgia Pastorin, Riccardo Cardin, Alessandro Sperduti, Giampiero Spalluto, and Stefano Moro. Combining Selectivity and Affinity Predictions using an Integrated Support Vector Machine (SVM) Approach: an Alternative Tool to Discriminate Between the Human Adenosine A2A and A3 Receptor Pyrazolo-Triazolo-Pyrimidine Antagonists Binding Sites. Bioorganic & Medicinal Chemistry, 2009, 17 (14), 5259-5274.

Cang-Rong Jason Teng and Giorgia Pastorin* The Influence of Carbon Nanotubes on Enzyme Activity and Structure: Investigation of Different Immobilization Procedures through Enzyme Kinetics and Circular Dichroism Studies. Nanotechnology, 2009, 20, 255102.

Anton V. Dolzhenko, Giorgia Pastorin, Anna V. Dolzhenko, Wai Keung Chui. An aqueous medium synthesis and tautomerism study of 3(5)-amino-1,2,4-triazole. Tetrahedron Letters, 2009, 50 (18), 2124-2128.

Giorgia Pastorin*. Crucial Functionalizations of Carbon Nanotubes for an improved Drug Delivery: a valuable Option? Expert Opinion, Pharmaceutical Research, 2009, 26(4), 746-769.


2008

Nubia Yandar, Giorgia Pastorin, Maurizio Prato, Alberto Bianco, Manuel Elkin Patarroyo, Jose Manuel Lozano. Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model. Vaccine, 2008, 26, 5864-5873.

Anton V. Dolzhenko, Giorgia Pastorin, Anna V. Dolzhenko, Wai Keung Chui. A convenient method for the synthesis of 7-aminosubstituted 1,2,4-triazolo[1,5-a][1,3,5]triazine-5-amines. Tetrahedron Letters, 2008, 49, 7180–7183.

Lara Lacerda, Hanene Ali-Boucetta, Maria A Herrero, Giorgia Pastorin, Alberto Bianco, Maurizio Prato, Kostas Kostarelos. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine, 2008, 3(2), 149-161.

Bruno Fabre, Fanny Hauquier, Cyril Herrier, Giorgia Pastorin, Wei Wu, Alberto Bianco, Maurizio Prato, Philippe Hapiot, Dodzi Zigah, Mauro Prasciolu, Lisa Vaccari. Covalent Assembly and Micropatterning of Functionalized Multiwalled Carbon Nanotubes to Monolayer-Modified Si(111) Surfaces. Langmuir, 2008, 24, 6595-6602.

Chiara Bolcato, Claudia Cusan, Giorgia Pastorin, Giampiero Spalluto, Barbara Cacciari, Karl Norbert Klotz, Erika Morizzo, Stefano Moro. Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes. Purinergic Signalling, 2008, 4, 39–46.

Lisa Michielan, Magdalena Bacilieri, Andrea Schiesaro, Chiara Bolcato, Giorgia Pastorin, Giampiero Spalluto, Barbara Cacciari, Karl Norbet Klotz, Chosei Kaseda, Stefano Moro. Linear and Non-Linear 3D-QSAR Approaches in Tandem with Ligand-Based Homology Modeling as a Computational Strategy to Depict the Pyrazolo-Triazolo-Pyrimidine Antagonists Binding Site of the Human Adenosine A(2A) Receptor. Journal of chemical information and modeling, 2008, 48 (2), 350-363.

Yupeng Ren and Giorgia Pastorin*. Incorporation of Hexamethylmelamine inside Capped Carbon Nanotubes. Advanced Materials, 2008,20, 2031-2036.

Lara Lacerda, Anuradha Soundararajan, Ravi Singh, Giorgia Pastorin, Khuloud T. Al-Jamal, John Turton, Peter Frederik, Maria A. Herrero, Shouping Li, Ande Bao, Dimitris Emfietzoglou, Stephen Mather, William T. Phillips, Maurizio Prato, Alberto Bianco, Beth Goins, and Kostas Kostarelos. Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion. Advanced Materials, 2008, 20, 225-230.


2007

Lara Lacerda, Giorgia Pastorin, David Gathercole, Joanna Buddle, Maurizio Prato Prato, Alberto Bianco, Kostas Kostarelos. Intracellular Trafficking of Carbon Nanotubes by Confocal Laser Scanning Microscopy. Advanced Materials, 2007, 19, 1480-1484.

Kostas Kostarelos, Lara Lacerda, Giorgia Pastorin, Wei Wu, Sebastien Wieckowski, Jacqueline Luangsivillay, Sylvie Godefroy, Davide Pantarotto, Jean-Paul Briand, Sylviane Muller, Maurizio Prato and Alberto Bianco. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nature Nanotechnology, 2007, 2, 108-113.

Alberto Bianco, Wei Wu, Giorgia Pastorin, Cédric Klumpp, Lara Lacerda, Charalambos D. Partidos, Kostas Kostarelos, Maurizio Prato. “Carbon nanotube-based vectors for delivering immunotherapeutics and drugs”, in Nanomaterials for Medical Diagnosis and Therapy, Kumar C. Ed., Wiley-VCH, Weinheim, 2007, pp. 85-142.


2006

Stefano Moro, Magdalena Bacilieri, Barbara Cacciari, Chiara Bolcato, Claudia Cusan, Giorgia Pastorin, Karl-Norbert Klotz and Giampiero Spalluto. The application of a 3D-QSAR (autoMEP/PLS) approach as an efficient pharmacodynamic-driven filtering method for small-sized virtual library: Application to a lead optimization of a human A3 adenosine receptor antagonist. Bioorganic & Medicinal Chemistry, 2006, 14, 4923–4932.

Lara Lacerda, Giorgia Pastorin, Wei Wu, Maurizio Prato, Alberto Bianco, Kostas Kostarelos. Luminescence of Functionalized Carbon Nanotubes as a Tool to Monitor Bundle Formation and Dissociation in Water: The Effect of Plasmid-DNA Complexation. Advanced Functional Materials, 2006, 16, 1839-1846.

Fanny Hauquier, Giorgia Pastorin, Philippe Hapiot, Maurizio Prato, Alberto Bianco, Bruno Fabre. Carbon nanotube-functionalized silicon surfaces with efficient redox communication. Chem. Commun. 2006, 43, 4536-4538.

Hélène Dumortier, Stéphanie Lacotte, Giorgia Pastorin, Riccardo Marega, Wei Wu, Davide Bonifazi, Jean-Paul Briand, Sylviane Muller, Maurizio Prato, Alberto Bianco. Functionalized carbon nanotubes are non toxic and preserve the functionality of primary immune cells. Nano Letters, 2006, 6(7), 1522-1528.

Giorgia Pastorin, Silvia Marchesan, Johan Hoebeke, Tatiana Da Ros, Laurence Ehret-Sabatier, Jean-Paul Briand, Maurizio Prato, Alberto Bianco. Design and Activity of Cationic Fullerene Derivatives as Inhibitors of Acetylcholinesterase. Organic & Biomelecular Chemistry (Advance article), 2006, 4, 2556-2562.

Ravi Singh, Davide Pantarotto, Lara Lacerda, Giorgia Pastorin, Cedric Klumpp, Maurizio Prato, Alberto Bianco and Kostas Kostarelos. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci U S A. 2006, 103(9), 3357-3362.

Giorgia Pastorin, Tatiana Da Ros, Chiara Bolcato, Christian Montopoli, Stefano Moro, Barbara Cacciari, Pier Giovanni Baraldi, Katia Varani, Pier Andrea Borea and Giampiero Spalluto. Synthesis and biological studies of a new series of 5-heteroarylcarbamoylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidines as human A3 adenosine receptor antagonists. Influence of the heteroaryl substituent on binding affinity and molecular modeling investigations.J Med Chem. 2006, 49(5), 1720-1729.

Giorgia Pastorin, Wei Wu, Sébastien Wieckowski, Jean-Paul Briand, Kostas Kostarelos, Maurizio Prato and Alberto Bianco. Double functionalisation of carbon nanotubes for multimodal drug delivery. Chem. Commun. 2006, 21(11),1182-1184.


2005

Wei Wu, Sébastien Wieckowski, Giorgia Pastorin, Jean-Paul Briand, Maurizio Prato, Alberto Bianco. Targeted Delivery of Amphotericin B to Cells Using Functionalised Carbon Nanotubes. Angew. Chem. Int. Ed., 2005, 44, 6358-6362.

Giorgia Pastorin, Chiara Bolcato, Barbara Cacciari, Sonja Kachler, Karl Norbert Klotz, Christian Montopoli, Stefano Moro, Giampiero Spalluto. Synthesis, biological and modeling studies of 1,3-di-n-propyl-2,4-dioxo-6-methyl-8-(substituted)-1,2,3,4-tetrahydro [1,2,4] triazolo[3,4-f]purines as potential adenosine receptor antagonists. Il Farmaco, 2005, 60, 643-651.

Barbara Cacciari, Giorgia Pastorin, Chiara Bolcato, Giampiero Spalluto, Magdalena Bacilieri, Stefano Moro. A2B Adenosine Receptor Antagonists: Recent Developments. Mini Rev. Med. Chem., 2005, 12, 1053-1060.

Giorgia Pastorin, Kostas Kostarelos, Maurizio Prato, Alberto Bianco. Functionalized Carbon Nanotubes: Towards the Delivery of Therapeutic Molecules. Journal of Biomedical Nanotechnology, 2005, 1, 133-142.

Giorgia Pastorin, Chiara Bolcato, Barbara Cacciari, Sonja Kachler, Karl-Norbert Klotz, Christian Montopoli, Stefano Moro, Giampiero Spalluto. Synthesis, biological studies and molecular modeling investigation of 1,3-dimethyl-2,4-dioxio-6-methyl-8-(substituted)1,2,3,4- tetrahydro[1,2,4]triazolo[3,4-f]purines as potential adenosine receptor antagonists. Il Farmaco, 2005, 60, 299-306.

Barbara Cacciari, Giorgia Pastorin, Stefano Moro, Giampiero Spalluto. Potent and selective A2A adenosine receptor antagonists: Recent Improvements. Frontiers in Medicinal Chemistry, 2005, 2, 49-62.

Stefano Moro, Paolo Braiuca, Francesca Deflorian, Giorgia Pastorin, Cristina Ferrari, Barbara Cacciari, Pier Giovanni Baraldi, Katia Varani, Pier Andrea Borea, Giampiero Spalluto. Combined Target-based and Ligand-based Drug Design Approach as a Tool to Define a Novel 3D-Pharmacophore Model of Human A3 Adenosine Receptor Antagonists: Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as a Key Study. J. Med. Chem., 2005, 48, 152-162.


2003

Stefano Moro, Francesca Deflorian, Giampiero Spalluto, Giorgia Pastorin, Barbara Cacciari, Soo-Kyung Kim, Kenneth A. Jacobson. Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling. Chem. Commun., 2003, 2949-2956.

Giorgia Pastorin, Tatiana Da Ros, Giampiero Spalluto, Francesca Deflorian, Stefano Moro, Barbara Cacciari, Pier Giovanni Baraldi, Stefania Gessi, Katia Varani, Pier Andrea Borea. Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as adenosine receptor antagonists. Influence of the N5 substituent on the affinity at the human A3 and A2B adenosine receptor subtypes: a molecular modeling investigation. J. Med. Chem., 2003, 46, 4287-4296.

Barbara Cacciari, Giorgia Pastorin, Giampiero Spalluto. Medicinal Chemistry of A2A adenosine receptor antagonists. Current Topic Med. Chem., 2003, 3, 403-411.


2002

Anna Maconi, Giorgia Pastorin, Tatiana Da Ros, Giampiero Spalluto, Zhan Guo Gao, Kenneth A. Jacobson, Pier Giovanni Baraldi, Barbara Cacciari, Katia Varani, Pier Andrea Borea. Synthesis, Biological properties and molecular modeling investigation of the first potent, selective and water soluble human A3 adenosine receptor antagonist. J. Med. Chem., 2002, 45, 3579-3582.

Pier Giovanni Baraldi, Barbara Cacciari, Romeo Romagnoli, Pier Andrea Borea, Katia Varani, Giorgia Pastorin, Tatiana Da Ros, Mojgan Aghazadeh Tabrizi, Francesca Fruttarolo, Giampiero Spalluto. Pyrazolo-triazolo-pyrimidine derivatives as adenosine receptor antagonists: A possible template for adenosine receptor subtypes? Current Pharmaceutical Design, 2002, 8, 2299-2332.

Pier Giovanni Baraldi, Barbara Cacciari, Stefano Moro, Giampiero Spalluto, Giorgia Pastorin, Tatiana Da Ros, Karl-Norbert Klotz, Katia Varani, Stefania Gessi, Pier Andrea Borea. Synthesis, biological activity and molecular modeling investigation of new pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A3 adenosine receptor antagonists. J. Med. Chem., 2002, 45, 770-780.



Last updated on 16 October 2016